학술논문
Gene Expression Profiling Reveals that PXR Activation Inhibits Hepatic PPARα Activity and Decreases FGF21 Secretion in Male C57Bl6/J Mice.
Document Type
Article
Author
Barretto, Sharon Ann; Lasserre, Frédéric; Fougerat, Anne; Smith, Lorraine; Fougeray, Tiffany; Lukowicz, Céline; Polizzi, Arnaud; Smati, Sarra; Régnier, Marion; Naylies, Claire; Bétoulières, Colette; Lippi, Yannick; Guillou, Hervé; Loiseau, Nicolas; Gamet-Payrastre, Laurence; Mselli-Lakhal, Laila; Ellero-Simatos, Sandrine
Source
International Journal of Molecular Sciences; Aug2019, Vol. 20 Issue 15, p3767-3767, 1p, 4 Graphs
Subject
Language
ISSN
16616596
Abstract
The article examines the transcriptomic signature of pregnane X receptor (PXR) activation in the liver of adult wild-type vs. Pxr -/- C57BI6/J male mice treated with the rodent specific ligand pregnenolone 16-carbonitrile. Topics covered include potential metabolic dysregulations induced upon PXR activation, effect of PXR activation on physiological parameters and liver lipids, and the effects of PXR activation on the hepatic transcriptome.