학술논문
Constructing the Framework for Disease Modification in Pulmonary Arterial Hypertension.
Document Type
Article
Author
Source
American Journal of Respiratory & Critical Care Medicine; 5/15/2024, Vol. 209 Issue 10, p1189-1195, 7p
Subject
Language
ISSN
1073449X
Abstract
The article discusses the concept of disease modification in pulmonary arterial hypertension (PAH) and proposes a framework for its definition and evaluation in clinical trials. It defines disease modification as therapy-induced changes in clinical manifestations, disease trajectory, and outcomes due to an effect on the underlying pathophysiology. It proposes a randomized-withdrawal trial design to evaluate disease-modifying therapies effectively.