학술논문
[Changes in the cytochrone C and A (A3) content in the liver mitochondria of rats with hyperthyroidism].
Document Type
Academic Journal
Author
Source
Publisher: Administrativnoia Zdaniia Minzdrava Sssr Country of Publication: Russia (Federation) NLM ID: 0370627 Publication Model: Print Cited Medium: Print ISSN: 0365-9615 (Print) Linking ISSN: 03659615 NLM ISO Abbreviation: Biull Eksp Biol Med Subsets: MEDLINE
Subject
Language
Russian
ISSN
0365-9615
Abstract
Thyroxin was administered daily to male Wistar rats aged 1, 3, 12 and 24 months in a dose of 250 g per 100 g body weight. After 9 days there was a significant increase in the content of cytochromes c and a (a(3)). An appreciable rise in the cytochrome c content was recorded as long as after one day, whereas the content of cytochromes a (a(3)) did not exceed normal even after 2 days. Following one day the content of cytochromes a (a(3)) in 3-, 12-, and 24-month-old rats was sightly lower than in normal rats. A significant temporary increase in the c/a (a(3)) ratio was observed after 1-2 days only in 12- and 24-month-old rats. The c/a (a(3)) ratio increased with age. It is suggested that application of thyroid hormones may be promising in studies on the regulation of mitochondrial biogenesis.