학술논문
Patients with ANCA-Associated Glomerulonephritis and Connective Tissue Diseases: A Comparative Study from the Maine-Anjou AAV Registry.
Document Type
Academic Journal
Author
Guibert F; CHU Angers, Service de Néphrologie-Dialyse-Transplantation, Université d'Angers, 49100 Angers, France.; Garnier AS; CHU Angers, Service de Néphrologie-Dialyse-Transplantation, Université d'Angers, 49100 Angers, France.; Wacrenier S; CHU Angers, Service de Néphrologie-Dialyse-Transplantation, Université d'Angers, 49100 Angers, France.; Piccoli G; Service de Néphrologie, Centre Hospitalier du Mans, 72037 Le Mans, France.; Djema A; Service de Néphrologie, Centre Hospitalier de Cholet, 49300 Cholet, France.; Gansey R; Service de Néphrologie, Centre Hospitalier de Laval, 53000 Laval, France.; Demiselle J; CHU Angers, Service de Néphrologie-Dialyse-Transplantation, Université d'Angers, 49100 Angers, France.; Brilland B; CHU Angers, Service de Néphrologie-Dialyse-Transplantation, Université d'Angers, 49100 Angers, France.; CRCINA, INSERM, Université de Nantes, Université d'Angers, 49100 Angers, France.; Cousin M; CHU Angers, Service de Néphrologie-Dialyse-Transplantation, Université d'Angers, 49100 Angers, France.; Besson V; CHU Angers, Service de Néphrologie-Dialyse-Transplantation, Université d'Angers, 49100 Angers, France.; Duveau A; CHU Angers, Service de Néphrologie-Dialyse-Transplantation, Université d'Angers, 49100 Angers, France.; El Nasser K; Service de Néphrologie, Centre Hospitalier de Cholet, 49300 Cholet, France.; Coindre JP; Service de Néphrologie, Centre Hospitalier du Mans, 72037 Le Mans, France.; Croue A; CHU Angers, Département de Pathologie Cellulaire et Tissulaire, Université d'Angers, 49100 Angers, France.; Saint-André JP; CHU Angers, Département de Pathologie Cellulaire et Tissulaire, Université d'Angers, 49100 Angers, France.; Chevailler A; CRCINA, INSERM, Université de Nantes, Université d'Angers, 49100 Angers, France.; CHU Angers, Laboratoire d'Immunologie, Université d'Angers, 49100 Angers, France.; Subra JF; CHU Angers, Service de Néphrologie-Dialyse-Transplantation, Université d'Angers, 49100 Angers, France.; CRCINA, INSERM, Université de Nantes, Université d'Angers, 49100 Angers, France.; Augusto JF; CHU Angers, Service de Néphrologie-Dialyse-Transplantation, Université d'Angers, 49100 Angers, France. jfaugusto@chu-angers.fr.; CRCINA, INSERM, Université de Nantes, Université d'Angers, 49100 Angers, France. jfaugusto@chu-angers.fr.
Source
Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101606588 Publication Model: Electronic Cited Medium: Print ISSN: 2077-0383 (Print) Linking ISSN: 20770383 NLM ISO Abbreviation: J Clin Med Subsets: PubMed not MEDLINE
Subject
Language
English
ISSN
2077-0383
Abstract
Background and Objectives: The overlap between antineutrophil cytoplasmic antibody (ANCA) associated glomerulonephritis (ANCA-GN) and connective tissue diseases (CTD) has been reported mainly as case series in the literature. Frequency of this association, as well as presentation and outcomes are unknown.
Materials and Methods: Patients from the Maine-Anjou ANCA-associated vasculitides (AAV) registry with ANCA-GN diagnosed between 01/01/2000 and 01/01/2018, ANCA positivity, and at least six months of follow-up, were included.
Results: 106 out of 142 patients fulfilled the inclusion criteria and were analyzed. CTD was present at ANCA-GN diagnosis in 16 (15.1%) patients. The most common CTD were rheumatoid arthritis, Sjogren syndrome and systemic sclerosis. Compared to the control group, females were more represented in the CTD group (75%, p = 0.001). Renal presentation was comparable between groups, including the pathological analysis of renal biopsies. Patients of CTD group presented a higher rate of non-renal relapse (25% versus 7.7%, p = 0.037), and experienced more frequently a venous thrombotic event (31.2% versus 10%, p = 0.021). No difference between groups was observed according to major outcomes.
Conclusion: Association between CTD and ANCA-GN is not a rare condition and predominantly affects females. While AAV presentation is not significantly different, CTD patients experience more frequently non-renal relapse and venous thrombotic events.
Materials and Methods: Patients from the Maine-Anjou ANCA-associated vasculitides (AAV) registry with ANCA-GN diagnosed between 01/01/2000 and 01/01/2018, ANCA positivity, and at least six months of follow-up, were included.
Results: 106 out of 142 patients fulfilled the inclusion criteria and were analyzed. CTD was present at ANCA-GN diagnosis in 16 (15.1%) patients. The most common CTD were rheumatoid arthritis, Sjogren syndrome and systemic sclerosis. Compared to the control group, females were more represented in the CTD group (75%, p = 0.001). Renal presentation was comparable between groups, including the pathological analysis of renal biopsies. Patients of CTD group presented a higher rate of non-renal relapse (25% versus 7.7%, p = 0.037), and experienced more frequently a venous thrombotic event (31.2% versus 10%, p = 0.021). No difference between groups was observed according to major outcomes.
Conclusion: Association between CTD and ANCA-GN is not a rare condition and predominantly affects females. While AAV presentation is not significantly different, CTD patients experience more frequently non-renal relapse and venous thrombotic events.