학술논문
Langherhans cell histiocytosis presenting as primary infertility in a young male.
Document Type
Academic Journal
Author
Kumar C; Laboratory Oncology Unit, Dr B.R.A. Institute Rotatory Cancer Hospital, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India.; Jain G; Laboratory Oncology Unit, Dr B.R.A. Institute Rotatory Cancer Hospital, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India.; Boro H; Department of Endocrinology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India.; Pushpam D; Department of Medical Oncology, Dr B.R.A. Institute Rotatory Cancer Hospital, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India.; Yadav M; Department of Radiology, Dr B.R.A. Institute Rotatory Cancer Hospital, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India.; Bakhshi S; Department of Endocrinology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India.; Mathur S; Department of Pathology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India.; Tanwar P; Department of Endocrinology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India.
Source
Publisher: Gulf Federation for Cancer Control Country of Publication: Kuwait NLM ID: 101500911 Publication Model: Print Cited Medium: Internet ISSN: 2078-2101 (Print) Linking ISSN: 20782101 NLM ISO Abbreviation: Gulf J Oncolog Subsets: MEDLINE
Subject
Language
English
ISSN
2078-2101
Abstract
Langerhans cell histiocytosis (LCH) is a rare clonal neoplastic disorder of Langerhans cells, with an incidence rate of 5 per million individuals. In adults LCH usually affects bone followed by lung, skin, pituitary gland, liver, spleen, and orbits. LCH presenting with endocrinopathy is rare and commonly involves posterior pituitary with central diabetes insipidus (DI). Here, we present a rare case of LCH involving posterior pituitary but presenting as infertility in a 25-year-old married man. Later the thyroid gland was also found to be involved in the form of multiple nodules. Fine needle aspiration cytology (FNAC) from right lobe of thyroid showed sheets of Langerhans cells along with entrapped residual thyroid follicular cells which were further confirmed by immunocytochemistry as well as cell block preparation followed by immunohistochemistry. A final diagnosis of LCH involving pituitary and thyroid was made and patient was then started on treatment according to LCH treatment protocol LCH III-6 consisting of prednisolone and vinblastine (6 weeks with daily 40 mg/m2 oral prednisolone, and 6 mg/m2 i.v. vinblastine every 7 days). Patient is responding well to the therapy and is on follow up.