학술논문
Factors associated with severe respiratory syncytial virus disease in hospitalised children: a retrospective analysis.
Document Type
Academic Journal
Author
Anderson J; Infection and Immunity, Murdoch Children's Research Institute, Parkville, Victoria, Australia jeremy.anderson@mcri.edu.au.; Department of Paediatrics, The University of Melbourne - Parkville Campus, Melbourne, Victoria, Australia.; Oeum M; Infection and Immunity, Murdoch Children's Research Institute, Parkville, Victoria, Australia.; Verkolf E; Erasmus University Rotterdam, Rotterdam, The Netherlands.; Licciardi PV; Infection and Immunity, Murdoch Children's Research Institute, Parkville, Victoria, Australia.; Department of Paediatrics, The University of Melbourne - Parkville Campus, Melbourne, Victoria, Australia.; Mulholland K; Infection and Immunity, Murdoch Children's Research Institute, Parkville, Victoria, Australia.; London School of Hygiene & Tropical Medicine, London, UK.; Nguyen C; The University of Melbourne Faculty of Medicine, Dentistry and Health Sciences, Melbourne, Victoria, Australia.; Chow K; Department of Paediatrics, The University of Melbourne - Parkville Campus, Melbourne, Victoria, Australia.; Waller G; The Royal Children's Hospital Melbourne, Parkville, Victoria, Australia.; Costa AM; The Royal Children's Hospital Melbourne, Parkville, Victoria, Australia.; Daley A; Microbiology and Infection Control, The Royal Children's Hospital Melbourne, Parkville, Victoria, Australia.; Crawford NW; General Medicine, The Royal Children's Hospital Melbourne, Parkville, Victoria, Australia.; Babl FE; Emergency Department, The Royal Children's Hospital Melbourne, Parkville, Victoria, Australia.; Duke T; Intensive Care Unit and Department of Paediatrics, The Royal Children's Hospital Melbourne, University of Melbourne, Parkville, Victoria, Australia.; Do LAH; Infection and Immunity, Murdoch Children's Research Institute, Parkville, Victoria, Australia.; Department of Paediatrics, The University of Melbourne - Parkville Campus, Melbourne, Victoria, Australia.; Wurzel D; Infection and Immunity, Murdoch Children's Research Institute, Parkville, Victoria, Australia.; Department of Respiratory and Sleep Medicine, The Royal Children's Hospital Melbourne, Parkville, Victoria, Australia.; Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.
Source
Publisher: BMJ Pub. Group [etc.] Country of Publication: England NLM ID: 0372434 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1468-2044 (Electronic) Linking ISSN: 00039888 NLM ISO Abbreviation: Arch Dis Child Subsets: MEDLINE
Subject
Language
English
Abstract
Background: Early recognition of children at risk of severe respiratory syncytial virus (RSV) lower respiratory tract infection is important as it informs management decisions. We aimed to evaluate factors associated with severe disease among young children hospitalised with RSV infection.
Methods: We conducted a retrospective cohort study of all children <2 years of age hospitalised for RSV lower respiratory tract infection at a single tertiary paediatric hospital over three RSV seasons (January 2017-December 2019). We classified children as having 'moderate' or 'severe' disease based on the level of respiratory intervention and used univariable and multivariable regression models to determine factors associated with severe disease.
Results: Of 970 hospitalised children, 386 (40%) were classified as having 'severe' and 584 (60%) as having 'moderate' RSV disease. On multivariable analyses, age <2 months (OR: 2.3, 95% CI 1.6 to 3.3, p<0.0001), prematurity (OR: 1.6, 95% CI 1.1 to 2.4, p=0.02) and RSV-parainfluenza virus type 3 (PIV3) codetection (OR: 2.6, 95% CI 1.05 to 6.5, p=0.04) were independently associated with severe disease.
Conclusion: Younger age, prematurity and PIV3 codetection were associated with severe RSV disease in children <2 years of age hospitalised with RSV infection. The association between PIV3 and severe RSV disease is a novel finding and warrants further investigation.
Competing Interests: Competing interests: None declared.
(© Author(s) (or their employer(s)) 2022. No commercial re-use. See rights and permissions. Published by BMJ.)
Methods: We conducted a retrospective cohort study of all children <2 years of age hospitalised for RSV lower respiratory tract infection at a single tertiary paediatric hospital over three RSV seasons (January 2017-December 2019). We classified children as having 'moderate' or 'severe' disease based on the level of respiratory intervention and used univariable and multivariable regression models to determine factors associated with severe disease.
Results: Of 970 hospitalised children, 386 (40%) were classified as having 'severe' and 584 (60%) as having 'moderate' RSV disease. On multivariable analyses, age <2 months (OR: 2.3, 95% CI 1.6 to 3.3, p<0.0001), prematurity (OR: 1.6, 95% CI 1.1 to 2.4, p=0.02) and RSV-parainfluenza virus type 3 (PIV3) codetection (OR: 2.6, 95% CI 1.05 to 6.5, p=0.04) were independently associated with severe disease.
Conclusion: Younger age, prematurity and PIV3 codetection were associated with severe RSV disease in children <2 years of age hospitalised with RSV infection. The association between PIV3 and severe RSV disease is a novel finding and warrants further investigation.
Competing Interests: Competing interests: None declared.
(© Author(s) (or their employer(s)) 2022. No commercial re-use. See rights and permissions. Published by BMJ.)