학술논문
Pregnancies and obstetrical prognosis after oocyte donation in Turner Syndrome: A multicentric study.
Document Type
Academic Journal
Author
Andre H; Univ Rennes, CHU, Centre d'AMP- CECOS, 16 Boulevard de Bulgarie, 35000, Rennes, France.; Pimentel C; Univ Rennes, CHU, Centre d'AMP- CECOS, 16 Boulevard de Bulgarie, 35000, Rennes, France.; Veau S; Univ Rennes, CHU, Centre d'AMP- CECOS, 16 Boulevard de Bulgarie, 35000, Rennes, France.; Domin-Bernhard M; Univ Rennes, CHU, Centre d'AMP- CECOS, 16 Boulevard de Bulgarie, 35000, Rennes, France.; Letur-Konirsch H; Centre de Fertilité, Institut Mutualiste Montsouris, 42, boulevard Jourdan, 75014, Paris, France.; Priou G; Clinique de la Sagesse, 4 Place Saint Guénolé-CS 44345, 35043, Rennes, France.; Eustache F; CECOS Jean Verdier, AP-HP, 93000, Bondy, France.; Vorilhon S; CHU Clermont, Ferrand, CGU Estaing, AMP, CECOS, 1 Place Aubrac, 63000, Clermont Ferrand, France.; Delepine-Panisset B; Biologie de la Reproduction, CECOS Champagne, Ardenne Pôle de Biologie Médicale et Pathologie 47 rue Cognacq-Jay, CHU, 51092 REIMS CEDEX, France.; Fauque P; CHU Dijon Bourgogne, Laboratoire de Biologie de la Reproduction, 14 rue Gaffarel, F-21000 Dijon, France.; Scheffler F; CECOS Picardie CHU, 80054, Amiens Cedex, France.; Benhaim A; Service de Biologie de la Reproduction Pôle de Biologie, CHU Côte de Nacre EA 2608 «OERECA», Esplanade de la Paix Université Caen Normandie, France.; Blagosklonov O; CECOS Franche-Comté, Service de Biologie de la Reproduction-Cryobiologie, CHRU Jean Minjoz Boulevard Fleming, 25030, Besançon, France.; Koscinski I; CHRU de Nancy, INSERM U954, Université de Lorraine, Service de Biologie de la Reproduction, CECOS, Maternité, 10 rue du Dr Heydenreich, 54000, Nancy, France.; Ravel C; Univ Rennes, CHU, Centre d'AMP- CECOS, 16 Boulevard de Bulgarie, 35000, Rennes, France; Univ Rennes, CHU Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail)-UMR_S 1085, F-35000 Rennes, France. Electronic address: celia.ravel@chu-rennes.fr.
Source
Publisher: Elsevier Scientific Publishers Country of Publication: Ireland NLM ID: 0375672 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7654 (Electronic) Linking ISSN: 03012115 NLM ISO Abbreviation: Eur J Obstet Gynecol Reprod Biol Subsets: MEDLINE
Subject
Language
English
Abstract
Introduction: Turner syndrome is one of the most frequent chromosomal abnormalities in women, with a prevalence estimated to be 1 of 2500 live birth. Pregnancy in women with Turner syndrome is known to be at high risk, whether it is spontaneous or after oocyte donation, because of miscarriages and potential cardio-vascular complications which can be life-threatening. All of these patients should therefore be screened with a comprehensive cardio-vascular assessment before pregnancy, and have a close follow-up during and after pregnancy.
Patients and Methods: It is a retrospective study, conducted in 10 of the 27 French oocyte donation centers between 2012 and 2016, on all the patients presenting with Turner syndrome included in an oocyte donation program.
Results: 151 embryo transfers were realized in 73 patients, resulting in 39 pregnancies. Among these pregnancies, 24 children were born healthy, 11 spontaneous miscarriages, 3 voluntary abortions, 1 extra-uterine pregnancy and 1 maternal death from non-cardio-vascular origin occurred. Pregnancies were complicated by gravid arterial hypertension in 28.2% of cases, preeclampsia in 10.3% of cases, and gestational diabetes in 7.7% of cases.
Conclusion: This study bring out obstetrical complications of the same magnitude than the ones described in the literature. Lead over a period of 4 years, in 10 French oocyte donation centers, it doesn't reveal any cardio-vascular complications, conversely to other studies published before French and American recommendations. This study reinforces the usefulness of specific recommendations for the care of these particular patients.
(Copyright © 2019 Elsevier B.V. All rights reserved.)
Patients and Methods: It is a retrospective study, conducted in 10 of the 27 French oocyte donation centers between 2012 and 2016, on all the patients presenting with Turner syndrome included in an oocyte donation program.
Results: 151 embryo transfers were realized in 73 patients, resulting in 39 pregnancies. Among these pregnancies, 24 children were born healthy, 11 spontaneous miscarriages, 3 voluntary abortions, 1 extra-uterine pregnancy and 1 maternal death from non-cardio-vascular origin occurred. Pregnancies were complicated by gravid arterial hypertension in 28.2% of cases, preeclampsia in 10.3% of cases, and gestational diabetes in 7.7% of cases.
Conclusion: This study bring out obstetrical complications of the same magnitude than the ones described in the literature. Lead over a period of 4 years, in 10 French oocyte donation centers, it doesn't reveal any cardio-vascular complications, conversely to other studies published before French and American recommendations. This study reinforces the usefulness of specific recommendations for the care of these particular patients.
(Copyright © 2019 Elsevier B.V. All rights reserved.)