학술논문

The genomics of heart failure: design and rationale of the HERMES consortium.
Document Type
Academic Journal
Author
Lumbers RT; Institute of Health Informatics, University College London, Gower St, London, WC1E 7HB, UK.; Health Data Research UK London, University College London, London, UK.; BHF Research Accelerator, University College London, London, UK.; Shah S; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.; Institute of Cardiovascular Science, University College London, London, UK.; Lin H; Section of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, Boston, MA, USA.; National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA, USA.; Czuba T; Department of Cardiology, Clinical Sciences, Lund University and Skåne University Hospital, Lund, Sweden.; Henry A; Institute of Health Informatics, University College London, Gower St, London, WC1E 7HB, UK.; Institute of Cardiovascular Science, University College London, London, UK.; Swerdlow DI; Institute of Cardiovascular Science, University College London, London, UK.; Department of Medicine, Imperial College London, London, UK.; Mälarstig A; Pfizer Worldwide Research & Development, Cambridge, MA, USA.; Cardiovascular Medicine Unit, Department of Medicine Solna, Karolinska Institute, Stockholm, Sweden.; Andersson C; National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA, USA.; Department of Cardiology, Herlev Gentofte Hospital, Herlev, Denmark.; Verweij N; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.; Holmes MV; Medical Research Council Population Health Research Unit at the University of Oxford, Oxford, UK.; Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, Big Data Institute, University of Oxford, Oxford, UK.; National Institute for Health Research Oxford Biomedical Research Centre, Oxford University Hospital, Oxford, UK.; Ärnlöv J; Department of Neurobiology, Care Sciences and Society/Section of Family Medicine and Primary Care, Karolinska Institutet, Stockholm, Sweden.; School of Health and Social Sciences, Dalarna University, Falun, Sweden.; Svensson P; Department of Clinical Science and Education, Karolinska Institutet, Södersjukhuset, Stockholm, Sweden.; Department of Cardiology, Södersjukhuset, Stockholm, Sweden.; Hemingway H; Institute of Health Informatics, University College London, Gower St, London, WC1E 7HB, UK.; Health Data Research UK London, University College London, London, UK.; The National Institute for Health Research, University College London Hospitals Biomedical Research Centre, University College London, London, UK.; Sallah N; Institute of Health Informatics, University College London, Gower St, London, WC1E 7HB, UK.; Health Data Research UK London, University College London, London, UK.; UCL Genetics Institute, University College London, London, UK.; Almgren P; Department of Clinical Sciences, Lund University, Malmö, Sweden.; Aragam KG; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.; Asselin G; Montreal Heart Institute, Montreal, Quebec, Canada.; Backman JD; Regeneron Genetics Center, Tarrytown, NY, USA.; Biggs ML; Department of Biostatistics, University of Washington, Seattle, WA, USA.; Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology and Health Services, University of Washington, Seattle, WA, USA.; Bloom HL; Division of Cardiology, Department of Medicine, Emory University Medical Center, Atlanta, GA, USA.; Boersma E; Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.; Brandimarto J; Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Brown MR; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.; Brunner-La Rocca HP; Maastricht University Medical Center, Maastricht, The Netherlands.; Carey DJ; Department of Molecular and Functional Genomics, Geisinger, Danville, PA, USA.; Chaffin MD; Cardiovascular Disease Initiative, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Chasman DI; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Chazara O; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.; Chen X; Pfizer Worldwide Research & Development, Cambridge, MA, USA.; Chen X; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.; Chung JH; Regeneron Genetics Center, Tarrytown, NY, USA.; Chutkow W; Novartis Institutes for Biomedical Research, Cambridge, MA, USA.; Cleland JGF; Robertson Centre for Biostatistics & Glasgow Clinical Trials Unit, Institute of Health and Wellbeing, University of Glasgow, Glasgow Royal Infirmary, Glasgow, UK.; National Heart and Lung Institute, Imperial College, London, UK.; Cook JP; Department of Biostatistics, University of Liverpool, Liverpool, UK.; de Denus S; Montreal Heart Institute, Montreal, Quebec, Canada.; Faculty of Pharmacy, Université de Montréal, Montreal, Quebec, Canada.; Dehghan A; Department of Epidemiology and Biostatistics, Imperial College London, St Mary's Campus, London, UK.; MRC-PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics, Imperial College London, St Mary's Campus, London, UK.; Delgado GE; Vth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Medical Faculty of Mannheim, University of Heidelberg, Heidelberg, Germany.; Denaxas S; Institute of Health Informatics, University College London, Gower St, London, WC1E 7HB, UK.; Health Data Research UK London, University College London, London, UK.; The National Institute for Health Research, University College London Hospitals Biomedical Research Centre, University College London, London, UK.; The Alan Turing Institute, British Library, London, UK.; Doney AS; Division of Molecular and Clinical Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK.; Dörr M; Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany.; DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.; Dudley SC; Cardiovascular Division, Department of Medicine, University of Minnesota, Minneapolis, MN, USA.; Engström G; Department of Clinical Sciences, Lund University, Malmö, Sweden.; Esko T; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.; Fatemifar G; Institute of Health Informatics, University College London, Gower St, London, WC1E 7HB, UK.; Health Data Research UK London, University College London, London, UK.; Felix SB; Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany.; DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.; Finan C; Institute of Cardiovascular Science, University College London, London, UK.; Ford I; Robertson Centre for Biostatistics & Glasgow Clinical Trials Unit, Institute of Health and Wellbeing, University of Glasgow, Glasgow Royal Infirmary, Glasgow, UK.; Fougerousse F; Translational and Clinical Research, Servier Cardiovascular Center for Therapeutic Innovation, Suresnes, France.; Fouodjio R; Montreal Heart Institute, Montreal, Quebec, Canada.; Ghanbari M; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.; Ghasemi S; DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.; Giedraitis V; Department of Public Health and Caring Sciences, Geriatrics, Uppsala University, Uppsala, Sweden.; Giulianini F; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Gottdiener JS; Department of Medicine, Division of Cardiology, University of Maryland School of Medicine, Baltimore, MD, USA.; Gross S; Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany.; DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.; Guðbjartsson DF; deCODE genetics/Amgen Inc., Reykjavik, Iceland.; School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland.; Gui H; Center for Individualized and Genomic Medicine Research, Department of Internal Medicine, Henry Ford Hospital, Detroit, MI, USA.; Gutmann R; Division of Cardiovascular Medicine, University of Iowa Carver College of Medicine, Iowa City, IA, USA.; Haggerty CM; Department of Translational Data Science and Informatics, Geisinger, Danville, PA, USA.; van der Harst P; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.; Durrer Center for Cardiogenetic Research, ICIN-Netherlands Heart Institute, Utrecht, The Netherlands.; Hedman ÅK; Cardiovascular Medicine Unit, Department of Medicine Solna, Karolinska Institute, Stockholm, Sweden.; Helgadottir A; deCODE genetics/Amgen Inc., Reykjavik, Iceland.; Hillege H; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.; Hyde CL; Pfizer Worldwide Research & Development, Cambridge, MA, USA.; Jacob J; Novartis Institutes for Biomedical Research, Cambridge, MA, USA.; Jukema JW; Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.; Netherlands Heart Institute, Utrecht, The Netherlands.; Kamanu F; Cardiovascular Disease Initiative, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Kardys I; Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.; Kavousi M; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.; Khaw KT; Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; Kleber ME; Vth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Medical Faculty of Mannheim, University of Heidelberg, Heidelberg, Germany.; Køber L; Department of Cardiology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.; Koekemoer A; Department of Cardiovascular Sciences, University of Leicester and NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK.; Kraus B; Duke Molecular Physiology Institute, Durham, NC, USA.; Kuchenbaecker K; UCL Genetics Institute, University College London, London, UK.; Division of Psychiatry, University College of London, London, UK.; Langenberg C; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, UK.; Lind L; Department of Medical Sciences, Uppsala University, Uppsala, Sweden.; Lindgren CM; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Big Data Institute at the Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK.; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.; London B; Division of Cardiovascular Medicine and Abboud Cardiovascular Research Center, University of Iowa, Iowa City, IA, USA.; Lotta LA; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, UK.; Lovering RC; Institute of Cardiovascular Science, University College London, London, UK.; Luan J; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, UK.; Magnusson P; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.; Mahajan A; Genentech Inc., San Francisco, CA, USA.; Mann D; Center for Cardiovascular Research, Division of Cardiology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.; Margulies KB; Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Marston NA; TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; März W; Vth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Medical Faculty of Mannheim, University of Heidelberg, Heidelberg, Germany.; Synlab Academy, Synlab Holding Deutschland GmbH, Mannheim, Germany.; Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria.; McMurray JJV; BHF Cardiovascular Research Centre, University of Glasgow, Glasgow, UK.; Melander O; Department of Internal Medicine, Clinical Sciences, Lund University and Skåne University Hospital, Malmö, Sweden.; Melloni G; Cardiovascular Disease Initiative, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Mordi IR; Division of Molecular and Clinical Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK.; Morley MP; Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Morris AD; Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.; Morris AP; Department of Biostatistics, University of Liverpool, Liverpool, UK.; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.; Morrison AC; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.; Nagle MW; Pfizer Worldwide Research & Development, Cambridge, MA, USA.; Nelson CP; Department of Cardiovascular Sciences, University of Leicester and NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK.; Newton-Cheh C; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.; Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, USA.; Niessner A; Department of Internal Medicine II, Division of Cardiology, Medical University of Vienna, Vienna, Austria.; Niiranen T; Finnish Institute for Health and Welfare, Helsinki, Finland.; Department of Medicine, Turku University Hospital and University of Turku, Turku, Finland.; Nowak C; Department of Neurobiology, Care Sciences and Society/Section of Family Medicine and Primary Care, Karolinska Institutet, Stockholm, Sweden.; O'Donoghue ML; TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Owens AT; Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Palmer CNA; Division of Molecular and Clinical Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK.; Paré G; Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.; Perola M; National Institute for Health and Welfare, Helsinki, Finland.; Perreault LL; Montreal Heart Institute, Montreal, Quebec, Canada.; Portilla-Fernandez E; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.; Division of Vascular Medicine and Pharmacology, Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands.; Psaty BM; Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology and Health Services, University of Washington, Seattle, WA, USA.; Kaiser Permanente Washington Health Research Institute, Kaiser Permanente Washington, Seattle, WA, USA.; Rice KM; Department of Biostatistics, University of Washington, Seattle, WA, USA.; Ridker PM; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Romaine SPR; Department of Cardiovascular Sciences, University of Leicester and NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK.; Roselli C; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.; Cardiovascular Disease Initiative, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Rotter JI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.; Ruff CT; TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Sabatine MS; TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Salo P; Finnish Institute for Health and Welfare, Helsinki, Finland.; Salomaa V; Finnish Institute for Health and Welfare, Helsinki, Finland.; van Setten J; Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, University of Utrecht, Utrecht, The Netherlands.; Shalaby AA; Division of Cardiology, Department of Medicine, University of Pittsburgh Medical Center and VA Pittsburgh HCS, Pittsburgh, PA, USA.; Smelser DT; Department of Molecular and Functional Genomics, Geisinger, Danville, PA, USA.; Smith NL; Kaiser Permanente Washington Health Research Institute, Kaiser Permanente Washington, Seattle, WA, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Department of Veterans Affairs Office of Research and Development, Seattle Epidemiologic Research and Information Center, Seattle, WA, USA.; Stefansson K; deCODE genetics/Amgen Inc., Reykjavik, Iceland.; Faculty of Medicine, Department of Medicine, University of Iceland, Reykjavik, Iceland.; Stender S; Department of Clinical Biochemistry, Copenhagen University Hospital, Herlev and Gentofte, Denmark.; Stott DJ; Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.; Sveinbjörnsson G; deCODE genetics/Amgen Inc., Reykjavik, Iceland.; Tammesoo ML; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.; Tardif JC; Montreal Heart Institute, Montreal, Quebec, Canada.; Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada.; Taylor KD; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.; Teder-Laving M; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.; Teumer A; DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.; Thorgeirsson G; deCODE genetics/Amgen Inc., Reykjavik, Iceland.; Faculty of Medicine, Department of Medicine, University of Iceland, Reykjavik, Iceland.; Thorsteinsdottir U; deCODE genetics/Amgen Inc., Reykjavik, Iceland.; Faculty of Medicine, Department of Medicine, University of Iceland, Reykjavik, Iceland.; Torp-Pedersen C; Department of Epidemiology and Biostatistics, Aalborg University Hospital, Aalborg, Denmark.; Department of Health, Science and Technology, Aalborg University Hospital, Aalborg, Denmark.; Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark.; Trompet S; Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.; Section of Gerontology and Geriatrics, Department of Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands.; Tuckwell D; Novartis Institutes for Biomedical Research, Cambridge, MA, USA.; Tyl B; Translational and Clinical Research, Servier Cardiovascular Center for Therapeutic Innovation, Suresnes, France.; Uitterlinden AG; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.; Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.; Vaura F; Finnish Institute for Health and Welfare, Helsinki, Finland.; Department of Clinical Medicine, University of Turku, Turku, Finland.; Veluchamy A; Division of Molecular and Clinical Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK.; Visscher PM; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.; Völker U; DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.; Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.; Voors AA; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.; Wang X; Novartis Institutes for Biomedical Research, Cambridge, MA, USA.; Wareham NJ; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, UK.; Weeke PE; Department of Cardiology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.; Weiss R; Division of Cardiovascular Medicine, Department of Internal Medicine, The Ohio State University Medical Center, Columbus, OH, USA.; White HD; Green Lane Cardiovascular Service, Auckland City Hospital, Auckland, New Zealand.; Wiggins KL; Department of Medicine, University of Washington, Seattle, WA, USA.; Xing H; Novartis Institutes for Biomedical Research, Cambridge, MA, USA.; Yang J; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.; Yang Y; Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Yerges-Armstrong LM; Human Genetics, GlaxoSmithKline, Collegeville, PA, USA.; Yu B; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.; Zannad F; CHU de Nancy, Inserm and INI-CRCT (F-CRIN), Institut Lorrain du Coeur et des Vaisseaux, Université de Lorraine, Nancy, France.; Zhao F; Novartis Institutes for Biomedical Research, Cambridge, MA, USA.; Wilk JB; Pfizer Worldwide Research & Development, Cambridge, MA, USA.; Holm H; deCODE genetics/Amgen Inc., Reykjavik, Iceland.; Sattar N; BHF Cardiovascular Research Centre, University of Glasgow, Glasgow, UK.; Lubitz SA; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiac Arrhythmia Service and Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.; Lanfear DE; Center for Individualized and Genomic Medicine Research, Department of Internal Medicine, Henry Ford Hospital, Detroit, MI, USA.; Heart and Vascular Institute, Henry Ford Hospital, Detroit, MI, USA.; Shah S; Duke Molecular Physiology Institute, Durham, NC, USA.; Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC, USA.; Duke Clinical Research Institute, Durham, NC, USA.; Dunn ME; Regeneron Pharmaceuticals, Cardiovascular Research, Tarrytown, NY, USA.; Wells QS; Division of Cardiovascular Medicine and the Vanderbilt Translational and Clinical Cardiovascular Research Center, Vanderbilt University, Nashville, TN, USA.; Asselbergs FW; Health Data Research UK London, University College London, London, UK.; BHF Research Accelerator, University College London, London, UK.; Institute of Cardiovascular Science, University College London, London, UK.; Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, University of Utrecht, Utrecht, The Netherlands.; Hingorani AD; BHF Research Accelerator, University College London, London, UK.; Institute of Cardiovascular Science, University College London, London, UK.; Dubé MP; Montreal Heart Institute, Montreal, Quebec, Canada.; Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada.; Samani NJ; Department of Cardiovascular Sciences, University of Leicester and NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK.; Lang CC; Division of Molecular and Clinical Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK.; Cappola TP; Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Ellinor PT; Cardiovascular Disease Initiative, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiac Arrhythmia Service and Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.; Vasan RS; National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA, USA.; Sections of Cardiology, Preventive Medicine and Epidemiology, Department of Medicine, Boston University Schools of Medicine and Public Health, Boston, MA, USA.; Smith JG; Department of Cardiology, Clinical Sciences, Lund University and Skåne University Hospital, Lund, Sweden.; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Wallenberg Center for Molecular Medicine and Lund University Diabetes Center, Lund University, Lund, Sweden.; The Wallenberg Laboratory/Department of Molecular and Clinical Medicine, Institute of Medicine, Gothenburg University and the Department of Cardiology, Sahlgrenska University Hospital, Gothenburg, Sweden.
Source
Publisher: John Wiley & Sons Ltd on behalf of the European Society of Cardiology Country of Publication: England NLM ID: 101669191 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2055-5822 (Electronic) Linking ISSN: 20555822 NLM ISO Abbreviation: ESC Heart Fail Subsets: MEDLINE
Subject
Language
English
Abstract
Aims: The HERMES (HEart failure Molecular Epidemiology for Therapeutic targetS) consortium aims to identify the genomic and molecular basis of heart failure.
Methods and Results: The consortium currently includes 51 studies from 11 countries, including 68 157 heart failure cases and 949 888 controls, with data on heart failure events and prognosis. All studies collected biological samples and performed genome-wide genotyping of common genetic variants. The enrolment of subjects into participating studies ranged from 1948 to the present day, and the median follow-up following heart failure diagnosis ranged from 2 to 116 months. Forty-nine of 51 individual studies enrolled participants of both sexes; in these studies, participants with heart failure were predominantly male (34-90%). The mean age at diagnosis or ascertainment across all studies ranged from 54 to 84 years. Based on the aggregate sample, we estimated 80% power to genetic variant associations with risk of heart failure with an odds ratio of ≥1.10 for common variants (allele frequency ≥ 0.05) and ≥1.20 for low-frequency variants (allele frequency 0.01-0.05) at P < 5 × 10 -8 under an additive genetic model.
Conclusions: HERMES is a global collaboration aiming to (i) identify the genetic determinants of heart failure; (ii) generate insights into the causal pathways leading to heart failure and enable genetic approaches to target prioritization; and (iii) develop genomic tools for disease stratification and risk prediction.
(© 2021 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology.)