학술논문
Nurse's A-Phase-Silicocarnotite Ceramic-Bone Tissue Interaction in a Rabbit Tibia Defect Model.
Document Type
Academic Journal
Author
Ñíguez Sevilla B; Orthopaedic Surgery and Traumatology Service, Santa Lucia University Hospital, 30202 Cartagena (Murcia), Spain. belnise@gmail.com.; Rabadan-Ros R; Regeneration and Tissue Repair Group, School of Medicine, Universidad Católica de Murcia, 30107 Murcia, Spain. rubenrabadanros@gmail.com.; Alcaraz-Baños M; Department of Radiology and Physical Medicine, School of Medicine, University of Murcia, 30100 Murcia, Spain. mab@um.es.; Martínez Díaz F; Department of Pathology. Reina Sofia University Hospital, University of Murcia, 30003 Murcia, Spain. fmdiaz@um.es.; Mate Sánchez de Val JE; Periodontology Department, Universidad Católica de Murcia, 30107 Murcia, Spain. jemate@ucam.edu.; López-Gónzalez I; Regeneration and Tissue Repair Group, School of Medicine, Universidad Católica de Murcia, 30107 Murcia, Spain. lopezgonzalez.iv@gmail.com.; Calvo-Guirado JL; Department of Oral and Implant Surgery, Universidad Católica de Murcia, 30107 Murcia, Spain. jlcalvo@ucam.edu.; De Aza PN; Instituto de Bioingeniería Universidad Miguel Hernández, Avda. Ferrocarril s/n. 03202 Elche (Alicante), Spain. piedad@umh.es.; Meseguer-Olmo L; Regeneration and Tissue Repair Group, School of Medicine, Universidad Católica de Murcia, 30107 Murcia, Spain. lmeseguer.doc@gmail.com.
Source
Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101606588 Publication Model: Electronic Cited Medium: Print ISSN: 2077-0383 (Print) Linking ISSN: 20770383 NLM ISO Abbreviation: J Clin Med Subsets: PubMed not MEDLINE
Subject
Language
English
ISSN
2077-0383
Abstract
Calcium phosphate materials are widely used as bone substitutes due to their bioactive and biodegradable properties. Also, the presence of silicon in their composition seems to improve the bioactivity of the implant and promote bone tissue repair. The aim of this study was to develop a novel ceramic scaffold by partial solid-state sintering method with a composition lying in the field of the Nurse's A-phase-silicocarnotite, in the tricalcium phosphate-dicalcium silicate (TCP-C 2 S) binary system. Also, we evaluated its osteogenic and osteoconductive properties after being implanted into tibia defects in New Zealand rabbits. X-ray, microcomputer tomography, and histomorphometry studies demonstrated that this porous ceramic is highly biocompatible and it has excellent osteointegration. The material was being progressively reabsorbed throughout the study and there was no unspecified local or systemic inflammatory response observed. These results suggest that ceramic imitates the physicochemical characteristics of bone substitutes used in bone reconstruction.