학술논문
Neurobiological basis and risk factors of persistent fatigue and concentration problems after COVID-19: study protocol for a prospective case-control study (VeCosCO).
Document Type
Academic Journal
Author
Verveen A; Amsterdam Public Health Research Institute, Amsterdam, The Netherlands.; Medical Psychology, Amsterdam UMC Location AMC, Amsterdam, The Netherlands.; Verfaillie SCJ; Medical Psychology, Amsterdam UMC Location AMC, Amsterdam, The Netherlands.; Radiology & Nuclear Medicine, Amsterdam UMC location VUmc, Amsterdam, The Netherlands.; Visser D; Radiology & Nuclear Medicine, Amsterdam UMC location VUmc, Amsterdam, The Netherlands.; Amsterdam Neuroscience - Brain Imaging, Amsterdam, The Netherlands.; Csorba I; Medical Psychology, Amsterdam UMC Location AMC, Amsterdam, The Netherlands.; Coomans EM; Radiology & Nuclear Medicine, Amsterdam UMC location VUmc, Amsterdam, The Netherlands.; Amsterdam Neuroscience - Brain Imaging, Amsterdam, The Netherlands.; Koch DW; Medical Psychology, Amsterdam UMC Location AMC, Amsterdam, The Netherlands.; Radiology and Nuclear Medicine, University Medical Center, Utrecht, The Netherlands.; Appelman B; Center for Experimental and Molecular Medicine, Amsterdam UMC Location AMC, Amsterdam, The Netherlands.; Barkhof F; Radiology & Nuclear Medicine, Amsterdam UMC location VUmc, Amsterdam, The Netherlands.; Queen Square Institute of Neurology and Centre for Medical Image Computing, University College London, London, UK.; Boellaard R; Radiology & Nuclear Medicine, Amsterdam UMC location VUmc, Amsterdam, The Netherlands.; de Bree G; Infectious Diseases, Amsterdam Institute for Infection and Immunity, Amsterdam, The Netherlands.; Infectious Diseases, Amsterdam UMC Location AMC, Amsterdam, The Netherlands.; van de Giessen EM; Radiology & Nuclear Medicine, Amsterdam UMC location VUmc, Amsterdam, The Netherlands.; Amsterdam Neuroscience - Brain Imaging, Amsterdam, The Netherlands.; Golla S; Radiology & Nuclear Medicine, Amsterdam UMC location VUmc, Amsterdam, The Netherlands.; Amsterdam Neuroscience - Brain Imaging, Amsterdam, The Netherlands.; van Heugten CM; Psychiatry and Neuropsychology, Maastricht University, Maastricht, The Netherlands.; Horn J; Amsterdam Neuroscience - Brain Imaging, Amsterdam, The Netherlands.; Intensive Care, Amsterdam UMC Location AMC, Amsterdam, The Netherlands.; Hulst HE; Anatomy & Neurosciences, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Medical, Health and Neuropsychology, Leiden University, Leiden, The Netherlands.; de Jong MD; Infectious Diseases, Amsterdam Institute for Infection and Immunity, Amsterdam, The Netherlands.; Medical Microbiology & Infection Prevention, Amsterdam UMC Location AMC, Amsterdam, The Netherlands.; Kuut TA; Amsterdam Public Health Research Institute, Amsterdam, The Netherlands.; Medical Psychology, Amsterdam UMC Location AMC, Amsterdam, The Netherlands.; van der Maaden T; Center for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands.; van Os YMG; Human Resources, University Medical Center, Utrecht, The Netherlands.; Prins M; Infectious Diseases, Amsterdam Institute for Infection and Immunity, Amsterdam, The Netherlands.; Infectious Diseases, Amsterdam UMC Location AMC, Amsterdam, The Netherlands.; Infectious Diseases, Public Health Service of Amsterdam, Amsterdam, The Netherlands.; Slooter AJC; Intensive Care, Amsterdam UMC Location AMC, Amsterdam, The Netherlands.; Brain Center, University Medical Centre, Utrecht, The Netherlands.; Psychiatry, Amsterdam UMC location AMC, Amsterdam, The Netherlands.; Neurology, UZ Brussel and Vrije Universiteit Brussel, Brussel, Belgium.; Visser-Meily JMA; Rehabilitation, Physical Therapy Science and Sports, Utrecht University, Utrecht, The Netherlands.; van Vugt M; Internal Medicine, Amsterdam UMC Location AMC, Amsterdam, The Netherlands.; van den Wijngaard CC; Center for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands.; Nieuwkerk PT; Amsterdam Public Health Research Institute, Amsterdam, The Netherlands.; Medical Psychology, Amsterdam UMC Location AMC, Amsterdam, The Netherlands.; Knoop H; Amsterdam Public Health Research Institute, Amsterdam, The Netherlands.; Medical Psychology, Amsterdam UMC Location AMC, Amsterdam, The Netherlands.; Tolboom N; Radiology and Nuclear Medicine, University Medical Center, Utrecht, The Netherlands N.Tolboom@umcutrecht.nl.; van Berckel BNM; Radiology & Nuclear Medicine, Amsterdam UMC location VUmc, Amsterdam, The Netherlands.; Amsterdam Neuroscience - Brain Imaging, Amsterdam, The Netherlands.
Source
Publisher: BMJ Publishing Group Ltd Country of Publication: England NLM ID: 101552874 Publication Model: Electronic Cited Medium: Internet ISSN: 2044-6055 (Electronic) Linking ISSN: 20446055 NLM ISO Abbreviation: BMJ Open Subsets: MEDLINE
Subject
Language
English
Abstract
Introduction: The risk factors for persistent fatigue and cognitive complaints after infection with SARS-CoV-2 and the underlying pathophysiology are largely unknown. Both clinical factors and cognitive-behavioural factors have been suggested to play a role in the perpetuation of complaints. A neurobiological aetiology, such as neuroinflammation, could be the underlying pathophysiological mechanism for persisting complaints.To unravel factors associated with persisting complaints, VeCosCO will compare individuals with and without persistent fatigue and cognitive complaints >3 months after infection with SARS-CoV-2. The study consists of two work packages. The first work package aims to (1) investigate the relation between persisting complaints and neuropsychological functioning; (2) determine risk factors and at-risk phenotypes for the development of persistent fatigue and cognitive complaints, including the presence of postexertional malaise and (3) describe consequences of persistent complaints on quality of life, healthcare consumption and physical functioning. The second work package aims to (1) determine the presence of neuroinflammation with [ 18 F]DPA-714 whole-body positron emission tomography (PET) scans in patients with persisting complaints and (2) explore the relationship between (neuro)inflammation and brain structure and functioning measured with MRI.
Methods and Analysis: This is a prospective case-control study in participants with and without persistent fatigue and cognitive complaints, >3 months after laboratory-confirmed SARS-CoV-2 infection. Participants will be mainly included from existing COVID-19 cohorts in the Netherlands covering the full spectrum of COVID-19 acute disease severity. Primary outcomes are neuropsychological functioning, postexertional malaise, neuroinflammation measured using [18 F]DPA-714 PET, and brain functioning and structure using (f)MRI.
Ethics and Dissemination: Work package 1 (NL79575.018.21) and 2 (NL77033.029.21) were approved by the medical ethical review board of the Amsterdam University Medical Centers (The Netherlands). Informed consent is required prior to participation in the study. Results of this study will be submitted for publication in peer-reviewed journals and shared with the key population.
Competing Interests: Competing interests: FB: Steering committee or iDMC member for Biogen, Merck, Roche, EISAI and Prothena. Consultant for Roche, Biogen, Merck, IXICO, Jansen, Combinostics. Research agreements with Merck, Biogen, GE Healthcare, Roche. Co-founder and shareholder of Queen Square Analytics.
(© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
Methods and Analysis: This is a prospective case-control study in participants with and without persistent fatigue and cognitive complaints, >3 months after laboratory-confirmed SARS-CoV-2 infection. Participants will be mainly included from existing COVID-19 cohorts in the Netherlands covering the full spectrum of COVID-19 acute disease severity. Primary outcomes are neuropsychological functioning, postexertional malaise, neuroinflammation measured using [
Ethics and Dissemination: Work package 1 (NL79575.018.21) and 2 (NL77033.029.21) were approved by the medical ethical review board of the Amsterdam University Medical Centers (The Netherlands). Informed consent is required prior to participation in the study. Results of this study will be submitted for publication in peer-reviewed journals and shared with the key population.
Competing Interests: Competing interests: FB: Steering committee or iDMC member for Biogen, Merck, Roche, EISAI and Prothena. Consultant for Roche, Biogen, Merck, IXICO, Jansen, Combinostics. Research agreements with Merck, Biogen, GE Healthcare, Roche. Co-founder and shareholder of Queen Square Analytics.
(© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)