학술논문
Breast conserving surgery with intraoperative electron beam radiation therapy for low-risk breast cancer: Five-year follow-up of 306 patients.
Document Type
Academic Journal
Author
de Jonge C; Department of Surgery, Catharina Hospital Eindhoven, Eindhoven, The Netherlands.; Schipper RJ; Department of Surgery, Catharina Hospital Eindhoven, Eindhoven, The Netherlands.; Walstra CJEF; Department of Surgery, Catharina Hospital Eindhoven, Eindhoven, The Netherlands.; Van Riet YE; Department of Surgery, Catharina Hospital Eindhoven, Eindhoven, The Netherlands.; Verrijssen AE; Department of Radiotherapy, Catharina Hospital Eindhoven, Eindhoven, The Netherlands.; Voogd AC; Department of Research and Development, Netherlands Comprehensive Cancer Organization (IKNL), Utrecht, The Netherlands.; Department of Epidemiology, Maastricht University Medical Center+, Maastricht, The Netherlands.; van der Sangen MJC; Department of Radiotherapy, Catharina Hospital Eindhoven, Eindhoven, The Netherlands.; Theuws J; Department of Radiotherapy, Catharina Hospital Eindhoven, Eindhoven, The Netherlands.; Degreef E; Department of Pathology, Eurofins PAMM, Veldhoven, The Netherlands.; Gielens MPM; Department of Radiology, Catharina Hospital Eindhoven, Eindhoven, The Netherlands.; Bloemen JG; Department of Surgery, Catharina Hospital Eindhoven, Eindhoven, The Netherlands.; van den Berg HA; Department of Radiotherapy, Catharina Hospital Eindhoven, Eindhoven, The Netherlands.; Nieuwenhuijzen GAP; Department of Surgery, Catharina Hospital Eindhoven, Eindhoven, The Netherlands.
Source
Publisher: Wiley-Liss Country of Publication: United States NLM ID: 0042124 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-0215 (Electronic) Linking ISSN: 00207136 NLM ISO Abbreviation: Int J Cancer Subsets: MEDLINE
Subject
Language
English
Abstract
Recent studies have reported a higher than expected risk of ipsilateral breast tumor recurrence (IBTR) after breast conserving surgery (BCS) and a single dose of electron beam intra-operative radiotherapy (IORT). This finding was the rationale to perform a retrospective single center cohort study evaluating the oncologic results of consecutive patients treated with BCS and IORT. Women were eligible if they had clinical low-risk (N0, ≤2 cm unifocal, Bloom and Richardson grade 1-2), estrogen receptor-positive and human-epidermal-growth-factor-receptor-2-negative breast cancer. Prior to BCS, pN0 status was determined by sentinel lymph node biopsy. Data on oncologic follow-up were analyzed. Between 2012 and 2019, 306 consecutive patients were treated and analyzed, with a median age of 67 (50-86) years at diagnosis. Median follow-up was 60 (8-120) months. Five-year cumulative risk of IBTR was 13.4% (95% confidence interval [CI] 9.4-17.4). True in field recurrence was present in 3.9% of the patients. In 4.6% of the patients, the IBRT was classified as a local recurrence due to seeding of tumor cells in the cutis or subcutis most likely related to percutaneous biopsy. In 2.9% of the patients, the IBRT was a new outfield primary tumor. Three patients had a regional lymph node recurrence and two had distant metastases as first event. One breast cancer-related death was observed. Estimated 5-year overall survival was 89.8% (95% CI 86.0-93.6). In conclusion, although some of IBTR cases could have been prevented by adaptations in biopsy techniques and patient selection, BCS followed by IORT was associated with a substantial risk of IBTR.
(© 2024 UICC.)
(© 2024 UICC.)