학술논문
Quality of Life in Women Diagnosed with Breast Cancer after a 12-Month Treatment of Lifestyle Modifications.
Document Type
Academic Journal
Author
Montagnese C; Epidemiology and Biostatistics Unit, Istituto Nazionale Tumori-IRCCS 'Fondazione G. Pascale', 80131 Napoli, Italy.; Porciello G; Epidemiology and Biostatistics Unit, Istituto Nazionale Tumori-IRCCS 'Fondazione G. Pascale', 80131 Napoli, Italy.; Vitale S; Epidemiology and Biostatistics Unit, Istituto Nazionale Tumori-IRCCS 'Fondazione G. Pascale', 80131 Napoli, Italy.; Palumbo E; Epidemiology and Biostatistics Unit, Istituto Nazionale Tumori-IRCCS 'Fondazione G. Pascale', 80131 Napoli, Italy.; Crispo A; Epidemiology and Biostatistics Unit, Istituto Nazionale Tumori-IRCCS 'Fondazione G. Pascale', 80131 Napoli, Italy.; Grimaldi M; Epidemiology and Biostatistics Unit, Istituto Nazionale Tumori-IRCCS 'Fondazione G. Pascale', 80131 Napoli, Italy.; Calabrese I; Department of Clinical Medicine and Surgery, Federico II University, 80131 Napoli, Italy.; Pica R; Epidemiology and Biostatistics Unit, Istituto Nazionale Tumori-IRCCS 'Fondazione G. Pascale', 80131 Napoli, Italy.; Prete M; Epidemiology and Biostatistics Unit, Istituto Nazionale Tumori-IRCCS 'Fondazione G. Pascale', 80131 Napoli, Italy.; Falzone L; Epidemiology and Biostatistics Unit, Istituto Nazionale Tumori-IRCCS 'Fondazione G. Pascale', 80131 Napoli, Italy.; Libra M; Department of Biomedical and Biotechnological Sciences Oncologic, Clinical and General Pathology Section, University of Catania, 95131 Catania, Italy.; Cubisino S; Cannizzaro Hospital, 95126 Catania, Italy.; Poletto L; Cancer Epidemiology Unit, National Cancer Institute Centro di Riferimento Oncologico, IRCCS, 33081 Aviano, Italy.; Martinuzzo V; Cancer Epidemiology Unit, National Cancer Institute Centro di Riferimento Oncologico, IRCCS, 33081 Aviano, Italy.; Coluccia S; Epidemiology and Biostatistics Unit, Istituto Nazionale Tumori-IRCCS 'Fondazione G. Pascale', 80131 Napoli, Italy.; Esindi N; School of Life and Environmental Sciences and Charles Perkins Centre, University of Sydney, Sydney 2006, Australia.; Nocerino F; Epidemiology and Biostatistics Unit, Istituto Nazionale Tumori-IRCCS 'Fondazione G. Pascale', 80131 Napoli, Italy.; Minopoli A; Laboratory Medicine Unit, Istituto Nazionale Tumori-IRCCS 'Fondazione G. Pascale', 80131 Napoli, Italy.; Grilli B; Laboratory Medicine Unit, Istituto Nazionale Tumori-IRCCS 'Fondazione G. Pascale', 80131 Napoli, Italy.; Fiorillo PC; Laboratory Medicine Unit, Istituto Nazionale Tumori-IRCCS 'Fondazione G. Pascale', 80131 Napoli, Italy.; Cuomo M; Laboratory Medicine Unit, Istituto Nazionale Tumori-IRCCS 'Fondazione G. Pascale', 80131 Napoli, Italy.; Cavalcanti E; Laboratory Medicine Unit, Istituto Nazionale Tumori-IRCCS 'Fondazione G. Pascale', 80131 Napoli, Italy.; Thomas G; Clinica Mediterranea, 80122 Napoli, Italy.; Cianniello D; Division of Breast Oncology, Istituto Nazionale Tumori-IRCCS 'Fondazione G. Pascale', 80131 Napoli, Italy.; Pinto M; Rehabilitation Medicine Unit, Istituto Nazionale Tumori-IRCCS 'Fondazione G. Pascale', 80131 Napoli, Italy.; De Laurentiis M; Division of Breast Oncology, Istituto Nazionale Tumori-IRCCS 'Fondazione G. Pascale', 80131 Napoli, Italy.; Pacilio C; Division of Breast Oncology, Istituto Nazionale Tumori-IRCCS 'Fondazione G. Pascale', 80131 Napoli, Italy.; Rinaldo M; Division of Breast Oncology, Istituto Nazionale Tumori-IRCCS 'Fondazione G. Pascale', 80131 Napoli, Italy.; D'Aiuto M; Clinica Villa Fiorita, Aversa 81031, Italy.; Serraino D; Cancer Epidemiology Unit, National Cancer Institute Centro di Riferimento Oncologico, IRCCS, 33081 Aviano, Italy.; Massarut S; Cancer Epidemiology Unit, National Cancer Institute Centro di Riferimento Oncologico, IRCCS, 33081 Aviano, Italy.; Caggiari L; Immunopathology and Cancer Biomarkers Unit, National Cancer Institute Centro di Riferimento Oncologico, IRCCS, 33081 Aviano, Italy.; Evangelista C; Immunopathology and Cancer Biomarkers Unit, National Cancer Institute Centro di Riferimento Oncologico, IRCCS, 33081 Aviano, Italy.; Steffan A; Immunopathology and Cancer Biomarkers Unit, National Cancer Institute Centro di Riferimento Oncologico, IRCCS, 33081 Aviano, Italy.; Catalano F; Cannizzaro Hospital, 95126 Catania, Italy.; Banna GL; Cannizzaro Hospital, 95126 Catania, Italy.; Scandurra G; Cannizzaro Hospital, 95126 Catania, Italy.; Ferraù F; Ospedale San Vincenzo, 98039 Taormina, Italy.; Rossello R; Ospedale San Vincenzo, 98039 Taormina, Italy.; Antonelli G; Ospedale San Vincenzo, 98039 Taormina, Italy.; Guerra G; Ospedale Evangelico Betania, 80147 Napoli, Italy.; Farina A; Ospedale Evangelico Betania, 80147 Napoli, Italy.; Messina F; Ospedale Evangelico Betania, 80147 Napoli, Italy.; Riccardi G; Department of Clinical Medicine and Surgery, Federico II University, 80131 Napoli, Italy.; Gatti D; Rheumatology Unit, University of Verona, 37129 Verona, Italy.; Jenkins DJA; Departments of Nutritional Sciences and Medicine, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, ON M5S, Canada.; Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Toronto, Ontario, ON M5B 1T8, Canada.; Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, ON M5B 1T8, Canada.; Celentano E; Epidemiology and Biostatistics Unit, Istituto Nazionale Tumori-IRCCS 'Fondazione G. Pascale', 80131 Napoli, Italy.; Botti G; Scientific Directorate, Istituto Nazionale Tumori-IRCCS 'Fondazione G. Pascale', 80131 Napoli, Italy.; Augustin LSA; Epidemiology and Biostatistics Unit, Istituto Nazionale Tumori-IRCCS 'Fondazione G. Pascale', 80131 Napoli, Italy.
Source
Publisher: MDPI Publishing Country of Publication: Switzerland NLM ID: 101521595 Publication Model: Electronic Cited Medium: Internet ISSN: 2072-6643 (Electronic) Linking ISSN: 20726643 NLM ISO Abbreviation: Nutrients Subsets: MEDLINE
Subject
Language
English
Abstract
Healthy lifestyles are associated with better health-related quality of life (HRQoL), favorable prognosis and lower mortality in breast cancer (BC) survivors. We investigated changes in HRQoL after a 12-month lifestyle modification program in 227 BC survivors participating in DEDiCa trial (Mediterranean diet, exercise, vitamin D). HRQoL was evaluated through validated questionnaires: EQ-5D-3L, EORTC-QLQ-C30 and EORTC QLQ-BR23. Baseline changes were tested using analysis of variance. Multiple regression analyses were performed to assess treatment effects on HRQoL. Increases were observed in global health status ( p < 0.001), physical ( p = 0.003), role ( p = 0.002) and social functioning ( p < 0.001), body image ( p < 0.001), future perspective ( p < 0.001), well-being ( p = 0.001), and reductions in fatigue ( p < 0.001), nausea and vomiting ( p = 0.015), dyspnea ( p = 0.001), constipation ( p = 0.049), financial problems ( p = 0.012), sexual functioning ( p = 0.025), systematic therapy side effects ( p < 0.001) and breast symptoms ( p = 0.004). Multiple regression analyses found inverse associations between changes in BMI and global health status ( p = 0.048) and between serum 25(OH)D levels and breast symptoms ( p = 0.002). A healthy lifestyle treatment of traditional Mediterranean diet and exercise may impact positively on HRQoL in BC survivors possibly through reductions in body weight while vitamin D sufficiency may improve BC-related symptoms. These findings are relevant to BC survivors whose lower HRQoL negatively affects treatment compliance and disease outcomes.