학술논문
The prognostic role of end of treatment FDG-PET-CT in patients with diffuse large B cell lymphoma can be improved by considering it with absolute monocyte count at diagnosis.
Document Type
Academic Journal
Author
Marcheselli R; a Fondazione Italiana Linfomi Onlus , Modena , Italy.; Franceschetto A; b Department of Oncology and Hematology , Modena Cancer Center, Unit of Nuclear Medicine, University of Modena and Reggio Emilia , Modena , Italy.; Sacchi S; c Department of Oncology and Hematology , Modena Cancer Center, Unit of Target Therapy in Onco-Hematology and Osteoncology, University of Modena and Reggio Emilia , Modena , Italy.; Bari A; c Department of Oncology and Hematology , Modena Cancer Center, Unit of Target Therapy in Onco-Hematology and Osteoncology, University of Modena and Reggio Emilia , Modena , Italy.; Levy I; d Hematology unit B- Bnai Zion Medical Center , Haifa , Israel.; Pizzichini P; e Sant'Andrea Hospital , Rome , Italy.; Prosperi D; e Sant'Andrea Hospital , Rome , Italy.; D'Apollo R; f Unit of Nuclear Medicine , Policlinico di Modena, Rome , Italy.; Massi L; f Unit of Nuclear Medicine , Policlinico di Modena, Rome , Italy.; Casolo A; f Unit of Nuclear Medicine , Policlinico di Modena, Rome , Italy.; Pozzi S; c Department of Oncology and Hematology , Modena Cancer Center, Unit of Target Therapy in Onco-Hematology and Osteoncology, University of Modena and Reggio Emilia , Modena , Italy.; Marcheselli L; a Fondazione Italiana Linfomi Onlus , Modena , Italy.; Tadmor T; d Hematology unit B- Bnai Zion Medical Center , Haifa , Israel.; Prandini N; f Unit of Nuclear Medicine , Policlinico di Modena, Rome , Italy.; Cox MC; e Sant'Andrea Hospital , Rome , Italy.
Source
Publisher: Taylor & Francis Country of Publication: United States NLM ID: 9007422 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1029-2403 (Electronic) Linking ISSN: 10268022 NLM ISO Abbreviation: Leuk Lymphoma Subsets: MEDLINE
Subject
Language
English
Abstract
It is well established that some patients with diffuse large B-cell lymphoma (DLBCL) and the negative end of treatment PET-CT (EOT-PET-CT) will relapse, while a proportion with positive uptake can still obtain long-term EFS. We reviewed data of 200 consecutive, previously untreated patients with DLBCL recorded in Italy and Israel between 2007 and 2015. We found that patients with negative EOT-PET-CT with AMC > 630/mmc have a 3-years EFS of 72%, compared to those with AMC ≤ 630/mmc that have an EFS of 84%. Furthermore, considering patients with positive EOT-PET-CT, those with AMC > 630/mmc have a 3-years EFS of 8%, while those with AMC ≤ 630/mmc have an EFS of 38%. Thus, it appears that combining the gold standard for response evaluation EOT-PET-CT with a simple and inexpensive parameter like AMC at diagnosis, further improves prognostication in DLBCL. Applying this simple method can be useful for all doctors working in lymphoma clinical practice.