학술논문
Extranodal natural killer/T-cell lymphoma nasal type in a western population: Molecular profiling identifies new therapeutic targets.
Document Type
Report
Author
Gonzalez Barca E; Hematology Department, Institut Català d'Oncologia Hospitalet, Hospital Duran i Reynals, IDIBELL, Universitat de Barcelona, Barcelona, Spain.; Tomás-Roca L; Pathology Department, Instituto de Investigación Sanitaria Fundación Jiménez Díaz, Madrid, Spain.; Esteve A; Unit of Biomarkers and Susceptibility, Oncology Data Analytics Program (ODAP), Medical Oncology Department, B-ARGO Badalona, Catalan Institute of Oncology, Barcelona, Spain.; Rodriguez M; Pathology Department, Instituto de Investigación Sanitaria Fundación Jiménez Díaz, Madrid, Spain.; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), ISCIII, Madrid, Spain.; Gato L; Pathology Department, Instituto de Investigación Sanitaria Fundación Jiménez Díaz, Madrid, Spain.; Alonso-Alonso R; Pathology Department, Instituto de Investigación Sanitaria Fundación Jiménez Díaz, Madrid, Spain.; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), ISCIII, Madrid, Spain.; Martin Garcia-Sancho A; Hematology Department, Hospital Clínico Universitario de Salamanca (CAUSA/IBSAL), Salamanca, Spain.; Cordoba R; Hematology Department, Fundación Jiménez Díaz, Madrid, Spain.; Monter-Rovira A; Hematology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.; Bastos-Oreiro M; Hematology Department, Gregorio Marañon General University Hospital, Madrid, Spain.; Bergua Burgues JM; Hematology Department, Hospital San Pedro Alcántara, Caceres, Spain.; Sayas MJ; Hematology Department, Hospital Universitario Dr. Peset, Valencia, Spain.; Viguria Alegria MC; Hematology Department, Complejo Hospitalario de Navarra, Pamplona, Spain.; Sanchez-Blanco JJ; Hematology Department, Hospital Morales Messeguer, Murcia, Spain.; Roig Pellicer M; Hematology Department, Hospital La Fe, Valencia, Spain.; Luzardo Henriquez HD; Hematology Department, Hospital Dr. Negrín, Las Palmas de Gran Canaria, Spain.; de Oña R; Hematology Department, MD Anderson Cancer Center, Madrid, Spain.; Cabezudo ME; Hematology Department, Hospital de Sant Joan Despí Moisès Broggi, Barcelona, Spain.; Infante MS; Hematology Department, Hospital Infanta Leonor, Madrid, Spain.; Queizán Hernández JA; Hematology Department, Hospital General de Segovia, Segovia, Spain.; Sanz-Pamplona R; Unit of Biomarkers and Susceptibility, Oncology Data Analytics Program (ODAP), Catalan Institute of Oncology, Oncobell Program, Bellvitge Biomedical Research Institute (IDIBELL) and CIBERESP, Barcelona, Spain.; Blanco O; Pathology Department, Institute of Biomedical Research of Salamanca (IBSAL), Salamanca, Spain.; Mozos A; Pathology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.; Climent F; Pathology Department, Hospital Universitari de Bellvitge, IDIBELL, L'Hospitalet De Llobregat, Barcelona, Spain.; Piris MA; Pathology Department, Instituto de Investigación Sanitaria Fundación Jiménez Díaz, Madrid, Spain.
Source
Publisher: Wiley-Blackwell Country of Publication: United States NLM ID: 7610369 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-8652 (Electronic) Linking ISSN: 03618609 NLM ISO Abbreviation: Am J Hematol Subsets: MEDLINE
Subject
Language
English
Abstract
(A) Correlation matrix of unsupervised co-regulated genes, based on the 208 genes included in the NanoString platform. Some of the clusters of co-regulated genes corresponded to the following: Inflammatory cells; Epstein-Barr virus; B-cells; Cytotoxic T-cells; T-cells; and Proliferation. (B) Analysis of genomic alterations by targeted sequencing. Distribution of mutations in the 62 analyzed genes. Rows correspond to sequenced genes, columns represent individual patients. Color coding: green, missense; blue, synonymous; pink, frameshift; violet, Indel; red, stop gained; yellow, UTR.
(© 2023 Wiley Periodicals LLC.)
(© 2023 Wiley Periodicals LLC.)