학술논문
Systematic review of topical interventions for the management of odour in patients with chronic or malignant fungating wounds.
Document Type
Academic Journal
Author
Gethin G; School of Nursing and Midwifery, University of Galway, Galway, Ireland; Alliance for Research and Innovation in Wounds, University of Galway, Galway, Ireland; Geneva School of Health Science, HES-SO University of Applied Sciences and Arts, Western, Switzerland; Faculty of Medicine Nursing and Health Sciences, Monash University, Australia; CÚRAM, SFI Research Centre for Medical Devices, Ireland. Electronic address: Georgina.gethin@nuigalway.ie.; Vellinga A; School of Public Health, Physiotherapy and Sports Science, University College Dublin, Ireland. Electronic address: akke.vellinga@ucd.ie.; McIntosh C; Alliance for Research and Innovation in Wounds, University of Galway, Galway, Ireland; Discipline of Podiatric Medicine, School of Health Science, University of Galway, Galway, Ireland. Electronic address: caroline.mcintosh@nuigalway.ie.; Sezgin D; School of Nursing and Midwifery, University of Galway, Galway, Ireland; Alliance for Research and Innovation in Wounds, University of Galway, Galway, Ireland. Electronic address: duygu.sezgin@nuigalway.ie.; Probst S; Geneva School of Health Science, HES-SO University of Applied Sciences and Arts, Western, Switzerland; Faculty of Medicine Nursing and Health Sciences, Monash University, Australia; Care Directorate, University Hospital Geneva, Switzerland. Electronic address: sebastian.probst@hesge.ch.; Murphy L; School of Nursing and Midwifery, University of Galway, Galway, Ireland.; Carr P; School of Nursing and Midwifery, University of Galway, Galway, Ireland.; Ivory J; School of Nursing and Midwifery, University of Galway, Galway, Ireland; Alliance for Research and Innovation in Wounds, University of Galway, Galway, Ireland; Irish Research Council (IRC), Government of Ireland, Dublin, Ireland; Centre for Diabetes, Endocrinology and Metabolism, Galway University Hospital, Galway, Ireland.; Cunningham S; Advance Glycoscience Research Cluster, School of Natural Sciences, University of Galway, Galway, Ireland; CÚRAM, SFI Research Centre for Medical Devices, Ireland.; Oommen AM; Advance Glycoscience Research Cluster, School of Natural Sciences, University of Galway, Galway, Ireland; CÚRAM, SFI Research Centre for Medical Devices, Ireland.; Joshi L; Advance Glycoscience Research Cluster, School of Natural Sciences, University of Galway, Galway, Ireland; CÚRAM, SFI Research Centre for Medical Devices, Ireland.; Ffrench C; School of Nursing and Midwifery, University of Galway, Galway, Ireland; CÚRAM, SFI Research Centre for Medical Devices, Ireland; Centre for Pain Research, University of Galway, Ireland. Electronic address: cathal.ffrench@nuigalway.ie.
Source
Publisher: Tissue Viability Society Country of Publication: England NLM ID: 9306822 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 0965-206X (Print) Linking ISSN: 0965206X NLM ISO Abbreviation: J Tissue Viability
Subject
Language
English
ISSN
0965-206X
Abstract
Chronic wounds adversely affect the quality of life of individuals and odour is a well-recognised associated factor. Odour can affect sleep, well-being, social interactions, diet and potentially wound healing. This systematic review aims to examine the effectiveness of topical interventions in the management of odour associated with chronic and malignant fungating wounds. A systematic review guided by PRISMA recommendations of randomised controlled trials where odour intensity/odour is the primary outcome was undertaken. Inclusion criteria were adults (18 years and over) with chronic venous, arterial, diabetic or pressure ulcers or with malignant fungating wounds where odour has been managed through topical application of pharmacological/non-pharmacological agents. Searches were conducted in CENTRAL, CINAHL, EMBASE, MEDLINE, Scopus, and Web of Science. Eligibility screening, risk of bias assessment and data extraction was completed by authors working independently. Searches retrieved 171 titles and abstracts (157 post de-duplication). Thirteen studies were retained for full text review of which five (n = 137 individuals) examining the following treatments remained: metronidazole (n = 4), silver (n = 1). Meta-analysis was not possible but individual studies suggest improved outcomes (i.e., reduced odour) using metronidazole. Treatment options to manage wound odour are limited and hampered by lack of clinical trials, small sample sizes, and absence of standardised outcomes and consistent measurement. Whereas metronidazole and silver may have a role in controlling wound odour, robust and well-designed interventions with rigorous procedures and standardised odour outcomes are necessary to evaluate their contribution.
Competing Interests: Declaration of competing interest Georgina Gethin, Lokesh Joshi and Stephen Cunningham are Principal Investigators on a collaborative grant award with the financial support of Science Foundation Ireland (SFI) and B. Braun Hospicare Ltd. and is co-funded under the European Regional Development Fund under Grant Number 13/RC/2073. There are no other competing interests to declare.
(Copyright © 2022. Published by Elsevier Ltd.)
Competing Interests: Declaration of competing interest Georgina Gethin, Lokesh Joshi and Stephen Cunningham are Principal Investigators on a collaborative grant award with the financial support of Science Foundation Ireland (SFI) and B. Braun Hospicare Ltd. and is co-funded under the European Regional Development Fund under Grant Number 13/RC/2073. There are no other competing interests to declare.
(Copyright © 2022. Published by Elsevier Ltd.)