학술논문
Unusual phosphatidylcholine lipid phase behavior in the ionic liquid ethylammonium nitrate.
Document Type
Academic Journal
Author
Salvati Manni L; School of Chemistry and University of Sydney Nano Institute, The University of Sydney, Sydney, NSW 2006, Australia; School of Environmental and Life Sciences, University of Newcastle, Callaghan 2308, NSW, Australia.; Davies C; School of Chemistry and University of Sydney Nano Institute, The University of Sydney, Sydney, NSW 2006, Australia.; Wood K; Australian Centre for Neutron Scattering, Australian Nuclear Science and Technology Organization, New Illawarra Road, Lucas Heights, NSW 2234, Australia.; Assenza S; Departamento de Física Teórica de la Materia Condensada, Universidad Autónoma de Madrid, Madrid, Spain; Condensed Matter Physics Center (IFIMAC), Universidad Autónoma de Madrid, Madrid, Spain; Instituto Nicolás Cabrera, Universidad Autónoma de Madrid, Madrid, Spain.; Atkin R; School of Molecular Sciences, The University of Western Australia, Perth, WA 6009, Australia.; Warr GG; School of Chemistry and University of Sydney Nano Institute, The University of Sydney, Sydney, NSW 2006, Australia. Electronic address: gregory.warr@sydney.edu.au.
Source
Publisher: Academic Press Country of Publication: United States NLM ID: 0043125 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-7103 (Electronic) Linking ISSN: 00219797 NLM ISO Abbreviation: J Colloid Interface Sci Subsets: PubMed not MEDLINE; MEDLINE
Subject
Language
English
Abstract
Hypothesis: The forces that govern lipid self-assembly ionic liquids are similar to water, but their different balance can result in unexpected behaviour.
Experiments: The self-assembly behaviour and phase equilibria of two phospholipids, 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC) and 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC), in the most common protic ionic liquid, ethylammonium nitrate (EAN) have been investigated as function of composition and temperature by small- and wide-angle X-ray scattering (SAXS/WAXS) and small-angle neutron scattering (SANS).
Findings: Both lipids form unusual self-assembly structures and show complex and unexpected phase behaviour unlike that seen in water; DSPC undergoes a gel Lβ to crystalline L c phase transition on warming, while POPC forms worm-like micelles L 1 upon dilution. This surprising phase behaviour is attributed to the large size of the EAN ions that solvate the lipid headgroup compared to water changing amphiphile packing. Weaker H-bonding between EAN and lipid headgroups also contributes. These results provide new insight for the design of lipid based nanostructured materials in ionic liquids with atypical properties.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.)
Experiments: The self-assembly behaviour and phase equilibria of two phospholipids, 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC) and 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC), in the most common protic ionic liquid, ethylammonium nitrate (EAN) have been investigated as function of composition and temperature by small- and wide-angle X-ray scattering (SAXS/WAXS) and small-angle neutron scattering (SANS).
Findings: Both lipids form unusual self-assembly structures and show complex and unexpected phase behaviour unlike that seen in water; DSPC undergoes a gel L
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.)