학술논문
How representative are neuroimaging samples? Large-scale evidence for trait anxiety differences between fMRI and behaviour-only research participants.
Document Type
Academic Journal
Author
Charpentier CJ; Division of Humanities and Social Sciences, California Institute of Technology, Pasadena, CA 91125, USA.; Institute of Cognitive Neuroscience, University College London, London WC1N 3AZ, UK.; Faulkner P; Department of Psychology, University of Roehampton, London SW15 5PJ, UK.; Pool ER; Department of Psychology, University of Geneva, Geneva 1205, Switzerland.; Ly V; Department of Clinical Psychology, Leiden University, Leiden, 2333 AK, The Netherlands.; Leiden Institute for Brain and Cognition, Leiden University, Leiden 2300 RC, The Netherlands.; Tollenaar MS; Department of Clinical Psychology, Leiden University, Leiden, 2333 AK, The Netherlands.; Leiden Institute for Brain and Cognition, Leiden University, Leiden 2300 RC, The Netherlands.; Kluen LM; Division of Humanities and Social Sciences, California Institute of Technology, Pasadena, CA 91125, USA.; Fransen A; Division of Humanities and Social Sciences, California Institute of Technology, Pasadena, CA 91125, USA.; Yamamori Y; Institute of Cognitive Neuroscience, University College London, London WC1N 3AZ, UK.; Lally N; Institute of Cognitive Neuroscience, University College London, London WC1N 3AZ, UK.; Mkrtchian A; Institute of Cognitive Neuroscience, University College London, London WC1N 3AZ, UK.; Valton V; Institute of Cognitive Neuroscience, University College London, London WC1N 3AZ, UK.; Huys QJM; Institute of Cognitive Neuroscience, University College London, London WC1N 3AZ, UK.; Sarigiannidis I; Institute of Cognitive Neuroscience, University College London, London WC1N 3AZ, UK.; Morrow KA; Department of Psychology, University of Maryland, College Park, MD 20742, USA.; Krenz V; Department of Cognitive Psychology, Universität, Hamburg 20146, Germany.; Kalbe F; Department of Cognitive Psychology, Universität, Hamburg 20146, Germany.; Cremer A; Department of Cognitive Psychology, Universität, Hamburg 20146, Germany.; Zerbes G; Department of Cognitive Psychology, Universität, Hamburg 20146, Germany.; Kausche FM; Department of Cognitive Psychology, Universität, Hamburg 20146, Germany.; Wanke N; Department of Cognitive Psychology, Universität, Hamburg 20146, Germany.; Giarrizzo A; Department of Psychology, University of Geneva, Geneva 1205, Switzerland.; Pulcu E; Department of Psychiatry, University of Oxford, Oxford OX3 7JX, UK.; Murphy S; Department of Psychiatry, University of Oxford, Oxford OX3 7JX, UK.; Oxford Health NHS Foundation Trust, Warneford Hospital, Oxford OX4 4XN, UK.; Kaltenboeck A; Department of Psychiatry, University of Oxford, Oxford OX3 7JX, UK.; Department of Psychiatry and Psychotherapy, Clinical Division of Social Psychiatry, Medical University of Vienna, Vienna 1090, Austria.; Browning M; Department of Psychiatry, University of Oxford, Oxford OX3 7JX, UK.; Oxford Health NHS Foundation Trust, Warneford Hospital, Oxford OX4 4XN, UK.; Paul LK; Division of Humanities and Social Sciences, California Institute of Technology, Pasadena, CA 91125, USA.; Cools R; Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, 6525 AJ, The Netherlands.; Department of Psychiatry, Radboud University Medical Centre, Nijmegen 6500 HB, The Netherlands.; Roelofs K; Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, 6525 AJ, The Netherlands.; Pessoa L; Department of Psychology, University of Maryland, College Park, MD 20742, USA.; Harmer CJ; Department of Psychiatry, University of Oxford, Oxford OX3 7JX, UK.; Oxford Health NHS Foundation Trust, Warneford Hospital, Oxford OX4 4XN, UK.; Chase HW; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA.; Grillon C; National Institute of Mental Health, Bethesda, MD 20892, USA.; Schwabe L; Department of Cognitive Psychology, Universität, Hamburg 20146, Germany.; Roiser JP; Institute of Cognitive Neuroscience, University College London, London WC1N 3AZ, UK.; Robinson OJ; Institute of Cognitive Neuroscience, University College London, London WC1N 3AZ, UK.; O'Doherty JP; Division of Humanities and Social Sciences, California Institute of Technology, Pasadena, CA 91125, USA.
Source
Publisher: Oxford Journals, Oxford University Press Country of Publication: England NLM ID: 101288795 Publication Model: Print Cited Medium: Internet ISSN: 1749-5024 (Electronic) Linking ISSN: 17495016 NLM ISO Abbreviation: Soc Cogn Affect Neurosci Subsets: MEDLINE
Subject
Language
English
Abstract
Over the past three decades, functional magnetic resonance imaging (fMRI) has become crucial to study how cognitive processes are implemented in the human brain. However, the question of whether participants recruited into fMRI studies differ from participants recruited into other study contexts has received little to no attention. This is particularly pertinent when effects fail to generalize across study contexts: for example, a behavioural effect discovered in a non-imaging context not replicating in a neuroimaging environment. Here, we tested the hypothesis, motivated by preliminary findings (N = 272), that fMRI participants differ from behaviour-only participants on one fundamental individual difference variable: trait anxiety. Analysing trait anxiety scores and possible confounding variables from healthy volunteers across multiple institutions (N = 3317), we found robust support for lower trait anxiety in fMRI study participants, consistent with a sampling or self-selection bias. The bias was larger in studies that relied on phone screening (compared with full in-person psychiatric screening), recruited at least partly from convenience samples (compared with community samples), and in pharmacology studies. Our findings highlight the need for surveying trait anxiety at recruitment and for appropriate screening procedures or sampling strategies to mitigate this bias.
(© The Author(s) 2021. Published by Oxford University Press.)
(© The Author(s) 2021. Published by Oxford University Press.)