학술논문
Fecal microbiota transplantation to eradicate vancomycin-resistant enterococci colonization in case of an outbreak.
Document Type
Academic Journal
Author
Davido B; Service de maladies infectieuses et tropicales, hôpital Raymond-Poincaré, AP-HP, 104, boulevard Raymond-Poincaré, 92380 Garches, France. Electronic address: benjamin.davido@aphp.fr.; Batista R; Pharmacie hospitalière, hôpital Cochin, AP-HP, 75014 Paris, France.; Fessi H; Néphrologie, hôpital Tenon, AP-HP, 75010 Paris, France.; Michelon H; Pharmacie hospitalière, hôpital Raymond-Poincaré, AP-HP, 92380 Garches, France.; Escaut L; Service de maladies infectieuses, hôpital Bicêtre, AP-HP, 94270 Le Kremlin-Bicêtre, France.; Lawrence C; Laboratoire de microbiologie, hôpital Raymond-Poincaré, AP-HP, 92380 Garches, France.; Denis M; Laboratoire de microbiologie, hôpital Tenon, AP-HP, 75010 Paris, France.; Perronne C; Service de maladies infectieuses et tropicales, hôpital Raymond-Poincaré, AP-HP, 104, boulevard Raymond-Poincaré, 92380 Garches, France.; Salomon J; Service de maladies infectieuses et tropicales, hôpital Raymond-Poincaré, AP-HP, 104, boulevard Raymond-Poincaré, 92380 Garches, France.; Dinh A; Service de maladies infectieuses et tropicales, hôpital Raymond-Poincaré, AP-HP, 104, boulevard Raymond-Poincaré, 92380 Garches, France.
Source
Publisher: Elsevier Country of Publication: France NLM ID: 0311416 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1769-6690 (Electronic) Linking ISSN: 0399077X NLM ISO Abbreviation: Med Mal Infect Subsets: MEDLINE
Subject
Language
English
Abstract
Objective: A rapid and worrying emergence of vancomycin-resistant enterococci (VRE) gut colonization is occurring worldwide and may be responsible for outbreaks, especially in healthcare facilities. While no efficient decolonization strategies are recommended, we assessed fecal microbiota transplantation (FMT) to eradicate VRE colonization.
Patients and Method: Our main objective was to measure the impact of FMT on decolonization of VRE carriers, confirmed by at least two consecutive negative rectal swabs at one-week interval during a 3-month follow-up period. Patients received no antibiotic prior to the FMT.
Results: After a month only three patients remained colonized with VRE. Decolonization was associated with 87.5% (n=7) of success after three months as only one patient remained colonized.
Conclusion: Our first results confirm that the FMT seems to be safe, with an impact on VRE colonization over time that may help control outbreaks.
(Copyright © 2018 Elsevier Masson SAS. All rights reserved.)
Patients and Method: Our main objective was to measure the impact of FMT on decolonization of VRE carriers, confirmed by at least two consecutive negative rectal swabs at one-week interval during a 3-month follow-up period. Patients received no antibiotic prior to the FMT.
Results: After a month only three patients remained colonized with VRE. Decolonization was associated with 87.5% (n=7) of success after three months as only one patient remained colonized.
Conclusion: Our first results confirm that the FMT seems to be safe, with an impact on VRE colonization over time that may help control outbreaks.
(Copyright © 2018 Elsevier Masson SAS. All rights reserved.)