학술논문
Aspirin reduces blood cholesterol in copper-deficient rats: a potential antioxidant agent?
Document Type
Academic Journal
Author
Source
Publisher: W.B. Saunders Country of Publication: United States NLM ID: 0375267 Publication Model: Print Cited Medium: Print ISSN: 0026-0495 (Print) Linking ISSN: 00260495 NLM ISO Abbreviation: Metabolism Subsets: MEDLINE
Subject
Language
English
ISSN
0026-0495
Abstract
The purpose of this study was to examine whether the hypocholesterolemic effect of aspirin is to due to its antioxidant properties. Oxidative stress was induced in rats by feeding them a copper-deficient diet. Copper deficiency reduced the activity of the enzyme superoxide dismutase (SOD) and lowered liver copper concentration but elevated liver iron. The combination of reduced SOD activity, high liver iron, and low liver copper resulted in an oxidative stress assessed by increased liver lipid peroxidation compared with copper-adequate controls. In addition, copper-deficient rats exhibited elevation of blood cholesterol. The administration of aspirin lowered both liver lipid peroxidation and blood cholesterol. It is suggested that the hypocholesterolemic properties of aspirin could be due to its ability to reduce oxidative stress.
(Copyright 2001 by W.B. Saunders Company)
(Copyright 2001 by W.B. Saunders Company)