학술논문
Leptin and Adiponectin Serum Levels from Infancy to School Age: Factors Influencing Tracking.
Document Type
Academic Journal
Author
Gruszfeld D; 1 Children's Memorial Health Institute , Warsaw, Poland .; Kułaga Z; 1 Children's Memorial Health Institute , Warsaw, Poland .; Wierzbicka A; 1 Children's Memorial Health Institute , Warsaw, Poland .; Rzehak P; 2 Dr. von Hauner Children's Hospital, University of Munich Medical Centre , Munich, Germany .; Grote V; 2 Dr. von Hauner Children's Hospital, University of Munich Medical Centre , Munich, Germany .; Martin F; 3 Centre Hospitalier Chrétien St. Vincent , Liège-Rocourt, Belgium .; Poncelet P; 4 University Children's Hospital Queen Fabiola , Université Libre de Bruxelles, Brussels, Belgium .; Closa-Monasterolo R; 5 Universitat Rovira i Virgili , IISPV, Reus, Spain .; Escribano J; 5 Universitat Rovira i Virgili , IISPV, Reus, Spain .; Verduci E; 6 San Paolo Hospital University of Milan , Milan, Italy .; Riva E; 6 San Paolo Hospital University of Milan , Milan, Italy .; Koletzko B; 2 Dr. von Hauner Children's Hospital, University of Munich Medical Centre , Munich, Germany .
Source
Publisher: Mary Ann Liebert Country of Publication: United States NLM ID: 101542497 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2153-2176 (Electronic) Linking ISSN: 21532168 NLM ISO Abbreviation: Child Obes Subsets: MEDLINE
Subject
Language
English
Abstract
Background: Early adiponectin and leptin in children correlate with those measured at a later age. Prenatal and early life factors may influence the pattern of leptin and adiponectin longitudinal changes. We aimed to identify subgroups of children with distinct trajectories of leptin and adiponectin over the first eight years of life, and to explore determinants predisposing an individual to be included in a specific trajectory class.
Methods: The analysis was based on data obtained from the EU Childhood Obesity Project (CHOP) cohort. The current study involved 459 children with adiponectin and leptin measured at 6 months, 5½ and 8 years of age.
Results: Three groups of leptin trajectories were identified: low-decreasing, medium-stable, and high-increasing, and two trajectory groups for adiponectin: lower and higher. The risk to be classified in the high-increasing group was higher than in the low-decreasing group for female gender (OR 10.67; 95% CI 4.94-23.05; p < 0.001); formula feeding (OR 3.34; 95% CI 1.11-10.09; p < 0.05); maternal overweight (OR 4.43; 95% CI 2.20-8.94; p < 0.001); and smoking in pregnancy (OR 4.14; 95% CI 2.07-8.29; p < 0.001). No predictors for being in the higher vs. lower adiponectin group were discovered.
Conclusions: Mothers' smoking during pregnancy, maternal overweight, and formula feeding distinguished different courses of leptin trajectories; but the effect may be associated with changes in adiposity.
Methods: The analysis was based on data obtained from the EU Childhood Obesity Project (CHOP) cohort. The current study involved 459 children with adiponectin and leptin measured at 6 months, 5½ and 8 years of age.
Results: Three groups of leptin trajectories were identified: low-decreasing, medium-stable, and high-increasing, and two trajectory groups for adiponectin: lower and higher. The risk to be classified in the high-increasing group was higher than in the low-decreasing group for female gender (OR 10.67; 95% CI 4.94-23.05; p < 0.001); formula feeding (OR 3.34; 95% CI 1.11-10.09; p < 0.05); maternal overweight (OR 4.43; 95% CI 2.20-8.94; p < 0.001); and smoking in pregnancy (OR 4.14; 95% CI 2.07-8.29; p < 0.001). No predictors for being in the higher vs. lower adiponectin group were discovered.
Conclusions: Mothers' smoking during pregnancy, maternal overweight, and formula feeding distinguished different courses of leptin trajectories; but the effect may be associated with changes in adiposity.