학술논문
Fast and safe clinical response to sonidegib in a 98-year old woman affected by locally advanced basal cell carcinoma.
Document Type
Academic Journal
Author
Mason E; Section of Dermatology and Venereology, Department of Medicine, University of Verona, Verona, Italy.; Pascucci E; Schena D; Girolomoni G
Source
Publisher: University of California, Davis Country of Publication: United States NLM ID: 9610776 Publication Model: Electronic Cited Medium: Internet ISSN: 1087-2108 (Electronic) Linking ISSN: 10872108 NLM ISO Abbreviation: Dermatol Online J Subsets: MEDLINE
Subject
Language
English
Abstract
A 98-year-old woman presented with histologically confirmed locally advanced basal cell carcinoma of the face. A multidisciplinary approach excluded surgery because of the site near sensitive organs, extension, age, and comorbidities. Patient and caregivers declined radiotherapy considering the necessity of multiple hospital appointments. The patient was then placed on therapy with sonidegib, an oral inhibitor of the Hedgehog signaling pathway. There was a very rapid clinical response after only 28 days of treatment. The basal cell carcinoma improved progressively, with no adverse events reported. This case illustrates the efficacy and safety of this treatment in an advanced age patient. This treatment had a remarkably positive impact on quality of life, including that of the caregivers.