학술논문
3D Printing Decellularized Extracellular Matrix to Design Biomimetic Scaffolds for Skeletal Muscle Tissue Engineering.
Document Type
Academic Journal
Author
Baiguera S; Department of Fusion and Technologies for Nuclear Safety and Security, Diagnostic and Metrology (FSN-TECFIS-DIM), ENEA, Italy.; Department of Clinical Science and Translational Medicine, University of Rome 'Tor Vergata', Italy.; Interdepartmental Center for Regenerative Medicine (CIMER), University of Rome 'Tor Vergata', Italy.; Del Gaudio C; E. Amaldi Foundation, Via del Politecnico snc, 00133 Rome, Italy.; Di Nardo P; Department of Clinical Science and Translational Medicine, University of Rome 'Tor Vergata', Italy.; Interdepartmental Center for Regenerative Medicine (CIMER), University of Rome 'Tor Vergata', Italy.; L.L. Levshin Institute of Cluster Oncology, I. M. Sechenov First Medical University, 119991 Moscow, Russia.; Manzari V; Department of Clinical Science and Translational Medicine, University of Rome 'Tor Vergata', Italy.; Carotenuto F; Department of Fusion and Technologies for Nuclear Safety and Security, Diagnostic and Metrology (FSN-TECFIS-DIM), ENEA, Italy.; Department of Clinical Science and Translational Medicine, University of Rome 'Tor Vergata', Italy.; Interdepartmental Center for Regenerative Medicine (CIMER), University of Rome 'Tor Vergata', Italy.; Teodori L; Department of Fusion and Technologies for Nuclear Safety and Security, Diagnostic and Metrology (FSN-TECFIS-DIM), ENEA, Italy.; Interdepartmental Center for Regenerative Medicine (CIMER), University of Rome 'Tor Vergata', Italy.
Source
Publisher: Hindawi Pub. Co Country of Publication: United States NLM ID: 101600173 Publication Model: eCollection Cited Medium: Internet ISSN: 2314-6141 (Electronic) NLM ISO Abbreviation: Biomed Res Int Subsets: MEDLINE
Subject
Language
English
Abstract
Functional engineered muscles are still a critical clinical issue to be addressed, although different strategies have been considered so far for the treatment of severe muscular injuries. Indeed, the regenerative capacity of skeletal muscle (SM) results inadequate for large-scale defects, and currently, SM reconstruction remains a complex and unsolved task. For this aim, tissue engineered muscles should provide a proper biomimetic extracellular matrix (ECM) alternative, characterized by an aligned/microtopographical structure and a myogenic microenvironment, in order to promote muscle regeneration. As a consequence, both materials and fabrication techniques play a key role to plan an effective therapeutic approach. Tissue-specific decellularized ECM (dECM) seems to be one of the most promising material to support muscle regeneration and repair. 3D printing technologies, on the other side, enable the fabrication of scaffolds with a fine and detailed microarchitecture and patient-specific implants with high structural complexity. To identify innovative biomimetic solutions to develop engineered muscular constructs for the treatment of SM loss, the more recent (last 5 years) reports focused on SM dECM-based scaffolds and 3D printing technologies for SM regeneration are herein reviewed. Possible design inputs for 3D printed SM dECM-based scaffolds for muscular regeneration are also suggested.
Competing Interests: The authors declare that there is no conflict of interests regarding the publication of this paper.
(Copyright © 2020 Silvia Baiguera et al.)
Competing Interests: The authors declare that there is no conflict of interests regarding the publication of this paper.
(Copyright © 2020 Silvia Baiguera et al.)