학술논문
Variations in Circulating Active MMP-9 Levels During Renal Replacement Therapy.
Document Type
Academic Journal
Author
Rodríguez-Sánchez E; Cardiorenal Translational Laboratory, Institute of Research i+12 (imas12), Hospital Universitario 12 de Octubre, 28041, Madrid, Spain.; Navarro-García JA; Cardiorenal Translational Laboratory, Institute of Research i+12 (imas12), Hospital Universitario 12 de Octubre, 28041, Madrid, Spain.; Aceves-Ripoll J; Cardiorenal Translational Laboratory, Institute of Research i+12 (imas12), Hospital Universitario 12 de Octubre, 28041, Madrid, Spain.; Abarca-Zabalía J; Cardiorenal Translational Laboratory, Institute of Research i+12 (imas12), Hospital Universitario 12 de Octubre, 28041, Madrid, Spain.; Susmozas-Sánchez A; Cardiorenal Translational Laboratory, Institute of Research i+12 (imas12), Hospital Universitario 12 de Octubre, 28041, Madrid, Spain.; Bada-Bosch T; Service of Nephrology, Hospital Universitario 12 de Octubre, 28041, Madrid, Spain.; Hernández E; Service of Nephrology, Hospital Universitario 12 de Octubre, 28041, Madrid, Spain.; Mérida-Herrero E; Service of Nephrology, Hospital Universitario 12 de Octubre, 28041, Madrid, Spain.; Andrés A; Service of Nephrology, Hospital Universitario 12 de Octubre, 28041, Madrid, Spain.; Praga M; Service of Nephrology, Hospital Universitario 12 de Octubre, 28041, Madrid, Spain.; Fernández-Ruiz M; Unit of Infectious Diseases, Hospital Universitario 12 de Octubre, 28041, Madrid, Spain.; Aguado JM; Unit of Infectious Diseases, Hospital Universitario 12 de Octubre, 28041, Madrid, Spain.; Segura J; Cardiorenal Translational Laboratory, Institute of Research i+12 (imas12), Hospital Universitario 12 de Octubre, 28041, Madrid, Spain.; Ruilope LM; Cardiorenal Translational Laboratory, Institute of Research i+12 (imas12), Hospital Universitario 12 de Octubre, 28041, Madrid, Spain.; School of Doctoral Studies and Research, European University of Madrid, 28670, Madrid, Spain.; CIBER-CV, Hospital Universitario 12 de Octubre, 28041, Madrid, Spain.; Ruiz-Hurtado G; Cardiorenal Translational Laboratory, Institute of Research i+12 (imas12), Hospital Universitario 12 de Octubre, 28041, Madrid, Spain.; CIBER-CV, Hospital Universitario 12 de Octubre, 28041, Madrid, Spain.
Source
Publisher: MDPI Country of Publication: Switzerland NLM ID: 101596414 Publication Model: Electronic Cited Medium: Internet ISSN: 2218-273X (Electronic) Linking ISSN: 2218273X NLM ISO Abbreviation: Biomolecules Subsets: MEDLINE
Subject
Language
English
Abstract
Renal replacement therapy (RRT) is complicated by a chronic state of inflammation and a high mortality risk. However, different RRT modalities can have a selective impact on markers of inflammation and oxidative stress. We evaluated the levels of active matrix metalloproteinase (MMP)-9 in patients undergoing two types of dialysis (high-flux dialysis (HFD) and on-line hemodiafiltration (OL-HDF)) and in kidney transplantation (KT) recipients. Active MMP-9 was measured by zymography and ELISA before (pre-) and after (post-) one dialysis session, and at baseline and follow-up (7 and 14 days, and 1, 3, 6, and 12 months) after KT. Active MMP-9 decreased post-dialysis only in HFD patients, while the levels in OL-HDF patients were already lower before dialysis. Active MMP-9 increased at 7 and 14 days post-KT and was restored to baseline levels three months post-KT, coinciding with an improvement in renal function and plasma creatinine. Active MMP-9 correlated with pulse pressure as an indicator of arterial stiffness both in dialysis patients and KT recipients. In conclusion, active MMP-9 is better controlled in OL-HDF than in HFD and is restored to baseline levels along with stabilization of renal parameters after KT. Active MMP-9 might act as a biomarker of arterial stiffness in RRT.
Competing Interests: The authors declare no conflicts of interest.
Competing Interests: The authors declare no conflicts of interest.