학술논문
Collective behavior and self-organization in neural rosette morphogenesis.
Document Type
Academic Journal
Author
Miotto M; Center for Life Nano and Neuro Science, Istituto Italiano di Tecnologia, Rome, Italy.; Department of Physics, Sapienza University of Rome, Rome, Italy.; Rosito M; Center for Life Nano and Neuro Science, Istituto Italiano di Tecnologia, Rome, Italy.; Department of Physiology and Pharmacology V. Erspamer, Sapienza University of Rome, Rome, Italy.; Paoluzzi M; Departament de Física de la Matèria Condensada, Universitat de Barcelona, Barcelona, Spain.; de Turris V; Center for Life Nano and Neuro Science, Istituto Italiano di Tecnologia, Rome, Italy.; Folli V; Center for Life Nano and Neuro Science, Istituto Italiano di Tecnologia, Rome, Italy.; D-TAILS srl, Rome, Italy.; Leonetti M; Center for Life Nano and Neuro Science, Istituto Italiano di Tecnologia, Rome, Italy.; D-TAILS srl, Rome, Italy.; Soft and Living Matter Laboratory, Institute of Nanotechnology, Consiglio Nazionale delle Ricerche, Rome, Italy.; Ruocco G; Center for Life Nano and Neuro Science, Istituto Italiano di Tecnologia, Rome, Italy.; Department of Physics, Sapienza University of Rome, Rome, Italy.; Rosa A; Center for Life Nano and Neuro Science, Istituto Italiano di Tecnologia, Rome, Italy.; Department of Biology and Biotechnologies Charles Darwin, Sapienza University of Rome, Rome, Italy.; Gosti G; Center for Life Nano and Neuro Science, Istituto Italiano di Tecnologia, Rome, Italy.; Soft and Living Matter Laboratory, Institute of Nanotechnology, Consiglio Nazionale delle Ricerche, Rome, Italy.
Source
Publisher: Frontiers Media S.A Country of Publication: Switzerland NLM ID: 101630250 Publication Model: eCollection Cited Medium: Print ISSN: 2296-634X (Print) Linking ISSN: 2296634X NLM ISO Abbreviation: Front Cell Dev Biol Subsets: PubMed not MEDLINE
Subject
Language
English
ISSN
2296-634X
Abstract
Neural rosettes develop from the self-organization of differentiating human pluripotent stem cells. This process mimics the emergence of the embryonic central nervous system primordium, i.e., the neural tube, whose formation is under close investigation as errors during such process result in severe diseases like spina bifida and anencephaly. While neural tube formation is recognized as an example of self-organization, we still do not understand the fundamental mechanisms guiding the process. Here, we discuss the different theoretical frameworks that have been proposed to explain self-organization in morphogenesis. We show that an explanation based exclusively on stem cell differentiation cannot describe the emergence of spatial organization, and an explanation based on patterning models cannot explain how different groups of cells can collectively migrate and produce the mechanical transformations required to generate the neural tube. We conclude that neural rosette development is a relevant experimental 2D in-vitro model of morphogenesis because it is a multi-scale self-organization process that involves both cell differentiation and tissue development. Ultimately, to understand rosette formation, we first need to fully understand the complex interplay between growth, migration, cytoarchitecture organization, and cell type evolution.
Competing Interests: Author VF was employed by D-TAILS srl. Author ML was a collaborator of D-TAILS srl. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2023 Miotto, Rosito, Paoluzzi, de Turris, Folli, Leonetti, Ruocco, Rosa and Gosti.)
Competing Interests: Author VF was employed by D-TAILS srl. Author ML was a collaborator of D-TAILS srl. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2023 Miotto, Rosito, Paoluzzi, de Turris, Folli, Leonetti, Ruocco, Rosa and Gosti.)