학술논문
Oral Bone Tissue Regeneration: Mesenchymal Stem Cells, Secretome, and Biomaterials.
Document Type
Academic Journal
Author
Gugliandolo A; Department of Experimental Neurology, IRCCS Centro Neurolesi 'Bonino-Pulejo', Via Provinciale Palermo, Contrada Casazza, 98124 Messina, Italy.; Fonticoli L; Department of Innovative Technologies in Medicine & Dentistry, University 'G. d'Annunzio' Chieti-Pescara, Via dei Vestini, 31, 66100 Chieti, Italy.; Trubiani O; Department of Innovative Technologies in Medicine & Dentistry, University 'G. d'Annunzio' Chieti-Pescara, Via dei Vestini, 31, 66100 Chieti, Italy.; Rajan TS; Department of Biotechnology, School of Life Sciences, Karpagam Academy of Higher Education, Coimbatore 641021, India.; Marconi GD; Department of Medical, Oral and Biotechnological Sciences, University 'G. d'Annunzio' Chieti-Pescara, Via dei Vestini, 31, 66100 Chieti, Italy.; Bramanti P; Department of Experimental Neurology, IRCCS Centro Neurolesi 'Bonino-Pulejo', Via Provinciale Palermo, Contrada Casazza, 98124 Messina, Italy.; Mazzon E; Department of Experimental Neurology, IRCCS Centro Neurolesi 'Bonino-Pulejo', Via Provinciale Palermo, Contrada Casazza, 98124 Messina, Italy.; Pizzicannella J; 'Ss. Annunziata' Hospital, ASL 02 Lanciano-Vasto-Chieti, 66100 Chieti, Italy.; Diomede F; Department of Innovative Technologies in Medicine & Dentistry, University 'G. d'Annunzio' Chieti-Pescara, Via dei Vestini, 31, 66100 Chieti, Italy.
Source
Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
Subject
Language
English
Abstract
In the last few decades, tissue engineering has become one of the most studied medical fields. Even if bone shows self-remodeling properties, in some cases, due to injuries or anomalies, bone regeneration can be required. In particular, oral bone regeneration is needed in the dentistry field, where the functional restoration of tissues near the tooth represents a limit for many dental implants. In this context, the application of biomaterials and mesenchymal stem cells (MSCs) appears promising for bone regeneration. This review focused on in vivo studies that evaluated bone regeneration using biomaterials with MSCs. Different biocompatible biomaterials were enriched with MSCs from different sources. These constructs showed an enhanced bone regenerative power in in vivo models. However, we discussed also a future perspective in tissue engineering using the MSC secretome, namely the conditioned medium and extracellular vesicles. This new approach has already shown promising results for bone tissue regeneration in experimental models.