학술논문
PEG-supported synthesis of pyrazole oligoamides with peptide beta-sheet affinity.
Document Type
Academic Journal
Author
Cernovská K; Institut für Organische Chemie, Universität Regensburg, Germany.; Kemter M; Gallmeier HC; Rzepecki P; Schrader T; König B
Source
Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101154995 Publication Model: Print-Electronic Cited Medium: Print ISSN: 1477-0520 (Print) Linking ISSN: 14770520 NLM ISO Abbreviation: Org Biomol Chem Subsets: PubMed not MEDLINE
Subject
Language
English
ISSN
1477-0520
Abstract
Pyrazole amino acid oligoamides were prepared on polyethylene glycol starting from nitro pyrazole carboxylic acids or protected pyrazole amino acids. The polymer support facilitates product isolation during synthesis and makes the target oligoamides soluble in chloroform and water. This allows the determination of their binding properties towards peptides. Moderate affinity, which increases with the number of pyrazole units, is observed in chloroform and water.