학술논문
3D-printed versatile biliary stents with nanoengineered surface for anti-hyperplasia and antibiofilm formation.
Document Type
Academic Journal
Author
Lee H; Department of Biomedical-Chemical Engineering, The Catholic University of Korea, Bucheon, 14662, Gyeonggi-do, Republic of Korea.; Department of Biotechnology, The Catholic University of Korea, Bucheon, 14662, Republic of Korea.; Won DS; Biomedical Engineering Research Center, Asan Institute for Life Sciences, Asan Medical Center, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Republic of Korea.; Park S; Department of Biomedical-Chemical Engineering, The Catholic University of Korea, Bucheon, 14662, Gyeonggi-do, Republic of Korea.; Department of Biotechnology, The Catholic University of Korea, Bucheon, 14662, Republic of Korea.; Park Y; Biomedical Engineering Research Center, Asan Institute for Life Sciences, Asan Medical Center, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Republic of Korea.; Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Republic of Korea.; Kim JW; Biomedical Engineering Research Center, Asan Institute for Life Sciences, Asan Medical Center, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Republic of Korea.; Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Republic of Korea.; Han G; Department of Biomedical-Chemical Engineering, The Catholic University of Korea, Bucheon, 14662, Gyeonggi-do, Republic of Korea.; Department of Biotechnology, The Catholic University of Korea, Bucheon, 14662, Republic of Korea.; Na Y; Department of Biomedical-Chemical Engineering, The Catholic University of Korea, Bucheon, 14662, Gyeonggi-do, Republic of Korea.; Department of Biotechnology, The Catholic University of Korea, Bucheon, 14662, Republic of Korea.; Kang MH; Department of Biomedical-Chemical Engineering, The Catholic University of Korea, Bucheon, 14662, Gyeonggi-do, Republic of Korea.; Department of Biotechnology, The Catholic University of Korea, Bucheon, 14662, Republic of Korea.; Kim SB; Research Center, Metamorp Inc, Seoul, 08584, Republic of Korea.; Kang H; Department of Materials Science and Engineering, Korea University, Seoul, 02841, Republic of Korea.; Park JK; IMT Inc, Gwangju, 61086, Republic of Korea.; Jang TS; School of Biomedical Convergence Engineering, Pusan National University, Yangsan, 50612, Republic of Korea.; Lee SJ; Biofunctional Materials, Division of Applied Oral Sciences and Community Dental Care, Faculty of Dentistry, The University of Hong Kong, 34 Hospital Road, Sai Ying Pun, Hong Kong SAR, PR China.; Park SA; Nano-Convergence Manufacturing Systems Research Division, Korea Institute of Machinery and Materials (KIMM), Daejeon, 34103, Republic of Korea.; Lee SS; Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Republic of Korea.; Park JH; Biomedical Engineering Research Center, Asan Institute for Life Sciences, Asan Medical Center, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Republic of Korea.; Department of Convergence Medicine, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-Gil, Songpa-gu, Seoul, 05505, Republic of Korea.; Jung HD; Division of Materials Science and Engineering, Hanyang University, Seoul, 04763, Republic of Korea.
Source
Publisher: Ke Ai Publishing Country of Publication: China NLM ID: 101685294 Publication Model: eCollection Cited Medium: Internet ISSN: 2452-199X (Electronic) Linking ISSN: 2452199X NLM ISO Abbreviation: Bioact Mater Subsets: PubMed not MEDLINE
Subject
Language
English
Abstract
Biliary strictures are characterized by the narrowing of the bile duct lumen, usually caused by surgical biliary injury, cancer, inflammation, and scarring from gallstones. Endoscopic stent placement is a well-established method for the management of biliary strictures. However, maintaining optimal mechanical properties of stents and designing surfaces that can prevent stent-induced tissue hyperplasia and biofilm formation are challenges in the fabrication of biodegradable biliary stents (BBSs) for customized treatment. This study proposes a novel approach to fabricating functionalized polymer BBSs with nanoengineered surfaces using 3D printing. The 3D printed stents, fabricated from bioactive silica poly(ε-carprolactone) (PCL) via a sol-gel method, exhibited tunable mechanical properties suitable for supporting the bile duct while ensuring biocompatibility. Furthermore, a nanoengineered surface layer was successfully created on a sirolimus (SRL)-coated functionalized PCL (fPCL) stent using Zn ion sputtering-based plasma immersion ion implantation (S-PIII) treatment to enhance the performance of the stent. The nanoengineered surface of the SRL-coated fPCL stent effectively reduced bacterial responses and remarkably inhibited fibroblast proliferation and initial burst release of SRL in vitro systems. The physicochemical properties and biological behaviors, including in vitro biocompatibility and in vivo therapeutic efficacy in the rabbit bile duct, of the Zn-SRL@fPCL stent demonstrated its potential as a versatile platform for clinical applications in bile duct tissue engineering.
Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(© 2024 The Authors.)
Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(© 2024 The Authors.)