학술논문
HLA-A23/HLA-A24 serotypes and dementia interaction in the elderly: Association with increased soluble HLA class I molecules in plasma.
Document Type
Academic Journal
Author
Cardoso EM; ESS-IPG, School of Health Sciences, Polytechnic of Guarda, Guarda, Portugal.; CICS-UBI, Health Sciences Research Centre, University of Beira Interior, Covilhã, Portugal.; FCS-UBI, Faculty of Health Sciences, University of Beira Interior, Covilhã, Portugal.; Lourenço-Gomes V; ESS-IPG, School of Health Sciences, Polytechnic of Guarda, Guarda, Portugal.; Esgalhado AJ; CICS-UBI, Health Sciences Research Centre, University of Beira Interior, Covilhã, Portugal.; Reste-Ferreira D; CICS-UBI, Health Sciences Research Centre, University of Beira Interior, Covilhã, Portugal.; Oliveira N; CICS-UBI, Health Sciences Research Centre, University of Beira Interior, Covilhã, Portugal.; Amaral AS; CICS-UBI, Health Sciences Research Centre, University of Beira Interior, Covilhã, Portugal.; Martinho A; Molecular Genetics Laboratory, Coimbra Blood and Transplantation Center, Coimbra, Portugal.; Gama JMR; Centre of Mathematics and Applications, Faculty of Sciences, University of Beira Interior, Covilhã, Portugal.; Verde I; CICS-UBI, Health Sciences Research Centre, University of Beira Interior, Covilhã, Portugal.; Centre of Mathematics and Applications, Faculty of Sciences, University of Beira Interior, Covilhã, Portugal.; Lourenço O; CICS-UBI, Health Sciences Research Centre, University of Beira Interior, Covilhã, Portugal.; FCS-UBI, Faculty of Health Sciences, University of Beira Interior, Covilhã, Portugal.; Fonseca AM; CICS-UBI, Health Sciences Research Centre, University of Beira Interior, Covilhã, Portugal.; FCS-UBI, Faculty of Health Sciences, University of Beira Interior, Covilhã, Portugal.; Buchli R; Pure Protein LLC, Oklahoma City, Oklahoma, USA.; Arosa FA; CICS-UBI, Health Sciences Research Centre, University of Beira Interior, Covilhã, Portugal.; FCS-UBI, Faculty of Health Sciences, University of Beira Interior, Covilhã, Portugal.
Source
Publisher: Wiley Blackwell Country of Publication: England NLM ID: 101675570 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2059-2310 (Electronic) Linking ISSN: 20592302 NLM ISO Abbreviation: HLA Subsets: MEDLINE
Subject
Language
English
Abstract
MHC class I molecules regulate brain development and plasticity in mice and HLA class I molecules are associated with brain disorders in humans. We investigated the relationship between plasma-derived soluble human HLA class I molecules (sHLA class I), HLA class I serotypes and dementia. A cohort of HLA class I serotyped elderly subjects with no dementia/pre-dementia (NpD, n = 28), or with dementia (D, n = 28) was studied. Multivariate analysis was used to examine the influence of dementia and HLA class I serotype on sHLA class I levels, and to compare sHLA class I within four groups according to the presence or absence of HLA-A23/A24 and dementia. HLA-A23/A24 and dementia, but not age, significantly influenced the level of sHLA class I. Importantly, the concurrent presence of HLA-A23/A24 and dementia was associated with higher levels of sHLA class I (p < 0.001). This study has shown that the simultaneous presence of HLA-A23/HLA-A24 and dementia is associated with high levels of serum sHLA class I molecules. Thus, sHLA class I could be considered a biomarker of neurodegeneration in certain HLA class I carriers.
(© 2023 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
(© 2023 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)