학술논문
Impact of Kidney Failure on the Severity of COVID-19.
Document Type
Academic Journal
Author
Zarębska-Michaluk D; Department of Infectious Diseases, Jan Kochanowski University, 25-317 Kielce, Poland.; Jaroszewicz J; Department of Infectious Diseases and Hepatology, Medical University of Silesia, 40-055 Katowice, Poland.; Rogalska M; Department of Infectious Diseases and Hepatology, Medical University of Białystok, 15-089 Białystok, Poland.; Lorenc B; Pomeranian Center of Infectious Diseases, Department of Infectious Diseases, Medical University of Gdańsk, 80-210 Gdańsk, Poland.; Rorat M; Department of Infectious Diseases and Hepatology, Wrocław Medical University, 50-367 Wrocław, Poland.; Department of Forensic Medicine, Wrocław Medical University, 50-367 Wrocław, Poland.; Szymanek-Pasternak A; Department of Infectious Diseases and Hepatology, Wrocław Medical University, 50-367 Wrocław, Poland.; Piekarska A; Department of Infectious Diseases and Hepatology, Medical University of Łódź, 90-549 Łódź, Poland.; Berkan-Kawińska A; Department of Infectious Diseases and Hepatology, Medical University of Łódź, 90-549 Łódź, Poland.; Sikorska K; Department of Tropical and Parasitic Diseases, Medical University of Gdańsk, 80-210 Gdańsk, Poland.; Tudrujek-Zdunek M; Department of Infectious Diseases and Hepatology, Medical University of Lublin, 20-059 Lublin, Poland.; Oczko-Grzesik B; Department of Infectious Diseases and Hepatology, Medical University of Silesia, 40-055 Katowice, Poland.; Bolewska B; Department of Infectious Diseases, University of Medical Sciences, 61-701 Poznań, Poland.; Czupryna P; Department of the Infectious Diseases and Neuroinfections, Medical University in Białystok, 15-089 Białystok, Poland.; Kozielewicz D; Department of Infectious Diseases and Hepatology, Faculty of Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, 87-100 Toruń, Poland.; Kowalska J; Department of Adults Infectious Diseases, Medical University of Warsaw, 02-091 Warsaw, Poland.; Podlasin R; Hospital of Infectious Diseases in Warsaw, 01-201 Warsaw, Poland.; Kłos K; Department of Infectious Diseases and Allergology, Military Institute of Medicine, 04-141 Warsaw, Poland.; Mazur W; Clinical Department of Infectious Diseases in Chorzów, Medical University of Silesia, 41-500 Katowice, Poland.; Leszczyński P; Department of Rheumatology and Osteoporosis, Jozef Strus Hospital in Poznań, 61-285 Poznań, Poland.; Department of Rheumatology, Rehabilitation and Internal Medicine, Poznan University of Medical Sciences, 61-701 Poznań, Poland.; Szetela B; Department of Infectious Diseases, Liver Diseases and Acquired Immune Deficiencies, Wroclaw Medical University, 50-367 Wrocław, Poland.; Reczko K; Department of Infectious Diseases, Jan Kochanowski University, 25-317 Kielce, Poland.; Flisiak R; Department of Infectious Diseases and Hepatology, Medical University of Białystok, 15-089 Białystok, Poland.
Source
Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101606588 Publication Model: Electronic Cited Medium: Print ISSN: 2077-0383 (Print) Linking ISSN: 20770383 NLM ISO Abbreviation: J Clin Med Subsets: PubMed not MEDLINE
Subject
Language
English
ISSN
2077-0383
Abstract
Background: Patients with kidney failure are at an increased risk of progression to a severe form of coronavirus disease 2019 (COVID-19) with high mortality. The current analysis was aimed to assess the impact of renal failure on the severity of COVID-19 and identify the risk factors of the fatal outcome in this population.
Methods: The analysis included patients from the SARSTer database, a national real-world study evaluating treatment for COVID-19 in 30 Polish centers. Data were completed retrospectively and submitted online.
Results: A total of 2322 patients were included in the analysis. Kidney failure was diagnosed in 455 individuals (19.65%), of whom 373 presented moderate stage and 82 patients, including 14 dialysis individuals, presented severe renal failure. Patients with kidney failure were significantly older and demonstrated a more severe course of COVID-19. The age, baseline SpO2 , the ordinal scale of 4 and 5, neutrophil and platelet count, estimated glomerular filtration rate, and C-reactive protein concentration as well as malignancy and arterial hypertension were the independent predictors of 28-day mortality in logistic regression analysis.
Conclusions: Underlying kidney disease in patients with COVID-19 is among the leading factors associated with a higher risk of severe clinical presentation and increased mortality rate.
Methods: The analysis included patients from the SARSTer database, a national real-world study evaluating treatment for COVID-19 in 30 Polish centers. Data were completed retrospectively and submitted online.
Results: A total of 2322 patients were included in the analysis. Kidney failure was diagnosed in 455 individuals (19.65%), of whom 373 presented moderate stage and 82 patients, including 14 dialysis individuals, presented severe renal failure. Patients with kidney failure were significantly older and demonstrated a more severe course of COVID-19. The age, baseline SpO
Conclusions: Underlying kidney disease in patients with COVID-19 is among the leading factors associated with a higher risk of severe clinical presentation and increased mortality rate.