학술논문
Macrophages in dermatology: pathogenic roles and targeted therapeutics.
Document Type
Academic Journal
Author
Kuraitis D; Department of Dermatology, Tulane University, New Orleans, USA. dkuraiti@tulane.edu.; Rosenthal N; The Jackson Laboratory, Bar Harbor, USA.; National Heart and Lung Institute and BHF Centre for Research Excellence, Imperial College London, London, UK.; Boh E; Department of Dermatology, Tulane University, New Orleans, USA.; McBurney E; Department of Dermatology, Tulane University, New Orleans, USA.
Source
Publisher: Springer Verlag Country of Publication: Germany NLM ID: 8000462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-069X (Electronic) Linking ISSN: 03403696 NLM ISO Abbreviation: Arch Dermatol Res Subsets: MEDLINE
Subject
Language
English
Abstract
The field of macrophage biology is rapidly growing. Recent studies have shifted focus from classic wound healing roles to newly identified roles in dermatologic pathology. These studies have identified pathogenic roles of macrophages in relatively common conditions, such as psoriasis, skin cancer, and cutaneous T-cell lymphoma. Selective depletion of these cells or their associated cytokines leads to improved clinical outcome. Herein, we review recent animal and human studies that have elucidated novel pathogenic roles of macrophages in conditions frequently encountered by dermatologists and discuss clinically relevant macrophage-targeted therapies.
(© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH, DE part of Springer Nature.)
(© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH, DE part of Springer Nature.)