학술논문
Clinical Features and Outcomes of Patients With Malignancy and Takotsubo Syndrome: Observations From the International Takotsubo Registry.
Document Type
Academic Journal
Author
Cammann VL; University Heart Center Department of Cardiology University Hospital Zurich Zurich Switzerland.; Sarcon A; University of Southern California, Keck School of Medicine Los Angeles CA.; Ding KJ; University Heart Center Department of Cardiology University Hospital Zurich Zurich Switzerland.; Seifert B; Division of Biostatistics, Epidemiology, Biostatistics and Prevention Institute University of Zurich Switzerland.; Kato K; University Heart Center Department of Cardiology University Hospital Zurich Zurich Switzerland.; Di Vece D; University Heart Center Department of Cardiology University Hospital Zurich Zurich Switzerland.; Szawan KA; University Heart Center Department of Cardiology University Hospital Zurich Zurich Switzerland.; Gili S; University Heart Center Department of Cardiology University Hospital Zurich Zurich Switzerland.; Centro Cardiologico Monzino IRCCS Milan Italy.; Jurisic S; University Heart Center Department of Cardiology University Hospital Zurich Zurich Switzerland.; Bacchi B; University Heart Center Department of Cardiology University Hospital Zurich Zurich Switzerland.; Micek J; University Heart Center Department of Cardiology University Hospital Zurich Zurich Switzerland.; Frangieh AH; University Heart Center Department of Cardiology University Hospital Zurich Zurich Switzerland.; Deutsches Herzzentrum München Technische Universität München Munich Germany.; Napp LC; Department of Cardiology and Angiology Hannover Medical School Hannover Germany.; Jaguszewski M; First Department of Cardiology Medical University of Gdansk Poland.; Bossone E; Heart Department University Hospital 'San Giovanni di Dio e Ruggi d'Aragona' Salerno Italy.; Citro R; Heart Department University Hospital 'San Giovanni di Dio e Ruggi d'Aragona' Salerno Italy.; D'Ascenzo F; Division of Cardiology Department of Medical Sciences AOU Città della Salute e della Scienza University of Turin Italy.; Franke J; Department of Cardiology Heidelberg University Hospital Heidelberg Germany.; Noutsias M; Division of Cardiology, Angiology and Intensive Medical Care Department of Internal Medicine III University Hospital Halle Martin-Luther-University Halle Halle (Saale) Germany.; Knorr M; Cardiology 1 Center for Cardiology University Medical Center Mainz Mainz Germany.; Heiner S; Cardiology 1 Center for Cardiology University Medical Center Mainz Mainz Germany.; Burgdorf C; Heart and Vascular Centre Bad Bevensen Bad Bevensen Germany.; Koenig W; Deutsches Herzzentrum München Technische Universität München Munich Germany.; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance Munich Germany.; Thiele H; Department of Internal Medicine/Cardiology Heart Center Leipzig- University Hospital Leipzig Germany.; Tschöpe C; Department of Cardiology Charité, Campus Rudolf Virchow Berlin Germany.; Rajan L; TJ Health Partners Heart and Vascular Glasgow Kentucky.; Michels G; Department of Internal Medicine III Heart Center University of Cologne Germany.; Pfister R; Department of Internal Medicine III Heart Center University of Cologne Germany.; Cuneo A; Krankenhaus 'Maria Hilf' Medizinische Klinik Stadtlohn Germany.; Jacobshagen C; Clinic for Cardiology and Pneumology Georg August University Goettingen Goettingen Germany.; Karakas M; Department of General and Interventional Cardiology University Heart Center Hamburg Hamburg Germany.; DZHK (German Centre for Cardiovascular Research), partner site Hamburg/Kiel/Luebeck Hamburg Germany.; Banning A; Department of Cardiology John Radcliffe Hospital Oxford University Hospitals Oxford United Kingdom.; Cuculi F; Department of Cardiology Kantonsspital Lucerne Lucerne Switzerland.; Kobza R; Department of Cardiology Kantonsspital Lucerne Lucerne Switzerland.; Fischer TA; Department of Cardiology Kantonsspital Winterthur Winterthur Switzerland.; Vasankari T; Heart Center Turku University Hospital and University of Turku Finland.; Airaksinen KEJ; Heart Center Turku University Hospital and University of Turku Finland.; Dworakowski R; Department of Cardiology Kings College Hospital Kings Health Partners London United Kingdom.; Kaiser C; Department of Cardiology University Hospital Basel Basel Switzerland.; Osswald S; Department of Cardiology University Hospital Basel Basel Switzerland.; Galiuto L; Fondazione Policlinico Universitario A. Gemelli IRCCS Università Cattolica del Sacro Cuore Rome Italy.; Dichtl W; University Hospital for Internal Medicine III (Cardiology and Angiology) Medical University Innsbruck Innsbruck Austria.; Delmas C; Department of Cardiology and Cardiac Imaging Center University Hospital of Rangueil Toulouse France.; Lairez O; Department of Cardiology and Cardiac Imaging Center University Hospital of Rangueil Toulouse France.; Horowitz JD; Department of Cardiology Basil Hetzel Institute Queen Elizabeth Hospital University of Adelaide Australia.; Kozel M; Charles University in Prague and University Hospital Kralovske Vinohrady Prague Czech Republic.; Widimský P; Charles University in Prague and University Hospital Kralovske Vinohrady Prague Czech Republic.; Tousek P; Charles University in Prague and University Hospital Kralovske Vinohrady Prague Czech Republic.; Winchester DE; Department of Medicine College of Medicine University of Florida Gainesville FL.; Gilyarova E; Intensive coronary care Unit Moscow City Hospital # 1 named after N. Pirogov Moscow Russia.; Shilova A; Intensive coronary care Unit Moscow City Hospital # 1 named after N. Pirogov Moscow Russia.; Gilyarov M; Intensive coronary care Unit Moscow City Hospital # 1 named after N. Pirogov Moscow Russia.; El-Battrawy I; First Department of Medicine Faculty of Medicine University Medical Centre Mannheim (UMM) University of Heidelberg Mannheim Germany.; DZHK (German Center for Cardiovascular Research), partner site, Heidelberg-Mannheim Mannheim Germany.; Akin I; First Department of Medicine Faculty of Medicine University Medical Centre Mannheim (UMM) University of Heidelberg Mannheim Germany.; DZHK (German Center for Cardiovascular Research), partner site, Heidelberg-Mannheim Mannheim Germany.; Ukena C; Klinik für Innere Medizin III Universitätsklinikum des Saarlandes Homburg/Saar Germany.; Bauersachs J; Department of Cardiology and Angiology Hannover Medical School Hannover Germany.; Pieske BM; Department of Cardiology Charité, Campus Rudolf Virchow Berlin Germany.; Hasenfuß G; Clinic for Cardiology and Pneumology Georg August University Goettingen Goettingen Germany.; Rottbauer W; Department of Internal Medicine II - Cardiology University of Ulm, Medical Center Ulm Germany.; Braun-Dullaeus RC; Internal Medicine/Cardiology, Angiology, and Pneumology Magdeburg University Magdeburg Germany.; Opolski G; Department of Cardiology Medical University of Warsaw Poland.; MacCarthy P; Department of Cardiology Kings College Hospital Kings Health Partners London United Kingdom.; Felix SB; Department of Internal Medicine B University Medicine Greifswald Greifswald Germany.; DZHK (German Centre for Cardiovascular Research), partner site Greifswald Greifswald Germany.; Borggrefe M; First Department of Medicine Faculty of Medicine University Medical Centre Mannheim (UMM) University of Heidelberg Mannheim Germany.; DZHK (German Center for Cardiovascular Research), partner site, Heidelberg-Mannheim Mannheim Germany.; Di Mario C; Structural Interventional Cardiology Careggi University Hospital Florence Italy.; Crea F; Fondazione Policlinico Universitario A. Gemelli IRCCS Università Cattolica del Sacro Cuore Rome Italy.; Katus HA; Department of Cardiology Heidelberg University Hospital Heidelberg Germany.; Schunkert H; Deutsches Herzzentrum München Technische Universität München Munich Germany.; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance Munich Germany.; Münzel T; Cardiology 1 Center for Cardiology University Medical Center Mainz Mainz Germany.; Böhm M; Klinik für Innere Medizin III Universitätsklinikum des Saarlandes Homburg/Saar Germany.; Bax JJ; Department of Cardiology Leiden University Medical Centre Leiden The Netherlands.; Prasad A; Division of Cardiovascular Diseases Mayo Clinic Rochester MN.; Shinbane J; University of Southern California, Keck School of Medicine Los Angeles CA.; Lüscher TF; Center for Molecular Cardiology Schlieren Campus University of Zurich Zurich Switzerland.; Cardiology Royal Brompton & Harefield Hospital and Imperial College London United Kingdom.; Ruschitzka F; University Heart Center Department of Cardiology University Hospital Zurich Zurich Switzerland.; Ghadri JR; University Heart Center Department of Cardiology University Hospital Zurich Zurich Switzerland.; Templin C; University Heart Center Department of Cardiology University Hospital Zurich Zurich Switzerland.
Source
Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101580524 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2047-9980 (Electronic) Linking ISSN: 20479980 NLM ISO Abbreviation: J Am Heart Assoc Subsets: MEDLINE
Subject
Language
English
Abstract
Background Clinical characteristics and outcomes of takotsubo syndrome (TTS) patients with malignancy have not been fully elucidated. This study sought to explore differences in clinical characteristics and to investigate short- and long-term outcomes in TTS patients with or without malignancy. Methods and Results TTS patients were enrolled from the International Takotsubo Registry. The TTS cohort was divided into patients with and without malignancy to investigate differences in clinical characteristics and to assess short- and long-term mortality. A subanalysis was performed comparing long-term mortality between a subset of TTS patients with or without malignancy and acute coronary syndrome (ACS) patients with or without malignancy. Malignancy was observed in 16.6% of 1604 TTS patients. Patients with malignancy were older and more likely to have physical triggers, but less likely to have emotional triggers compared with those without malignancy. Long-term mortality was higher in patients with malignancy (P<0.001), while short-term outcome was comparable (P=0.17). In a subanalysis, long-term mortality was comparable between TTS patients with malignancies and ACS patients with malignancies (P=0.13). Malignancy emerged as an independent predictor of long-term mortality. Conclusions A substantial number of TTS patients show an association with malignancy. History of malignancy might increase the risk for TTS, and therefore, appropriate screening for malignancy should be considered in these patients. Clinical Trial Registration URL: http://www.clinicaltrial.gov. Unique identifier: NCT01947621.