학술논문
A polygenic score for age-at-first-birth predicts disinhibition.
Document Type
Academic Journal
Author
Richmond-Rakerd LS; Department of Psychology and Neuroscience, Duke University, Durham, NC, USA.; Frank Porter Graham Child Development Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Moffitt TE; Department of Psychology and Neuroscience, Duke University, Durham, NC, USA.; Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC, USA.; Center for Genomic and Computational Biology, Duke University, Durham, NC, USA.; Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK.; Arseneault L; Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK.; Belsky DW; Department of Epidemiology, Columbia University Mailman School of Public Health, New York, NY, USA.; Connor J; Department of Preventive and Social Medicine, University of Otago, Dunedin, New Zealand.; Corcoran DL; Center for Genomic and Computational Biology, Duke University, Durham, NC, USA.; Harrington H; Department of Psychology and Neuroscience, Duke University, Durham, NC, USA.; Houts RM; Department of Psychology and Neuroscience, Duke University, Durham, NC, USA.; Poulton R; Dunedin Multidisciplinary Health and Development Research Unit, Department of Psychology, University of Otago, Dunedin, New Zealand.; Prinz JA; Center for Genomic and Computational Biology, Duke University, Durham, NC, USA.; Ramrakha S; Dunedin Multidisciplinary Health and Development Research Unit, Department of Psychology, University of Otago, Dunedin, New Zealand.; Sugden K; Department of Psychology and Neuroscience, Duke University, Durham, NC, USA.; Wertz J; Department of Psychology and Neuroscience, Duke University, Durham, NC, USA.; Williams BS; Department of Psychology and Neuroscience, Duke University, Durham, NC, USA.; Caspi A; Department of Psychology and Neuroscience, Duke University, Durham, NC, USA.; Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC, USA.; Center for Genomic and Computational Biology, Duke University, Durham, NC, USA.; Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK.
Source
Publisher: Blackwell Publishers Country of Publication: England NLM ID: 0375361 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-7610 (Electronic) Linking ISSN: 00219630 NLM ISO Abbreviation: J Child Psychol Psychiatry Subsets: MEDLINE
Subject
Language
English
Abstract
Background: A recent genome-wide association study identified molecular-genetic associations with age-at-first-birth. However, the meaning of these genetic discoveries is unclear. Drawing on evidence linking early pregnancy with disinhibitory behavior, we tested the hypothesis that genetic discoveries for age-at-first-birth predict disinhibition.
Methods: We included participants with genotype data from the two-decade-long Environmental Risk (E-Risk) Study (N = 1,999) and the four-decade-long Dunedin Study (N = 918). We calculated a genome-wide polygenic score for age-at-first-birth and tested whether it was associated with a range of disinhibitory outcomes across the life course, including low childhood self-control; risk for externalizing psychopathology; officially recorded criminal offending; substance dependence; informant reports of disinhibitory problems; and number of lifetime sexual partners. We further tested whether associations were attributable to accelerated pubertal maturation.
Results: In both cohorts, the age-at-first-birth polygenic score predicted low childhood self-control, externalizing psychopathology, officially recorded criminal offending, substance dependence, and number of sexual partners. Associations were modest, but robust across replication. Childhood disinhibition partly mediated associations between the polygenic score and reproductive behaviors. In contrast, associations were not attributable to accelerated pubertal timing.
Conclusions: Genomic discoveries for age-at-first-birth are about more than reproductive biology: They provide insight into the disinhibitory traits and behaviors that accompany early parenthood. Age-at-first-birth is a useful proxy phenotype for researchers interested in disinhibition. Further, interventions that improve self-regulation abilities may benefit young parents and their children.
(© 2020 The Authors. Journal of Child Psychology and Psychiatry published by John Wiley & Sons Ltd on behalf of Association for Child and Adolescent Mental Health.)
Methods: We included participants with genotype data from the two-decade-long Environmental Risk (E-Risk) Study (N = 1,999) and the four-decade-long Dunedin Study (N = 918). We calculated a genome-wide polygenic score for age-at-first-birth and tested whether it was associated with a range of disinhibitory outcomes across the life course, including low childhood self-control; risk for externalizing psychopathology; officially recorded criminal offending; substance dependence; informant reports of disinhibitory problems; and number of lifetime sexual partners. We further tested whether associations were attributable to accelerated pubertal maturation.
Results: In both cohorts, the age-at-first-birth polygenic score predicted low childhood self-control, externalizing psychopathology, officially recorded criminal offending, substance dependence, and number of sexual partners. Associations were modest, but robust across replication. Childhood disinhibition partly mediated associations between the polygenic score and reproductive behaviors. In contrast, associations were not attributable to accelerated pubertal timing.
Conclusions: Genomic discoveries for age-at-first-birth are about more than reproductive biology: They provide insight into the disinhibitory traits and behaviors that accompany early parenthood. Age-at-first-birth is a useful proxy phenotype for researchers interested in disinhibition. Further, interventions that improve self-regulation abilities may benefit young parents and their children.
(© 2020 The Authors. Journal of Child Psychology and Psychiatry published by John Wiley & Sons Ltd on behalf of Association for Child and Adolescent Mental Health.)