학술논문
Borderline Symptoms at Age 12 Signal Risk for Poor Outcomes During the Transition to Adulthood: Findings From a Genetically Sensitive Longitudinal Cohort Study.
Document Type
Academic Journal
Author
Wertz J; Duke University, Durham, North Carolina. Electronic address: jasmin.wertz@duke.edu.; Caspi A; Duke University, Durham, North Carolina; Duke University Medical Center, Durham, North Carolina; Social, Genetic & Developmental Psychiatry Center, Institute of Psychiatry, Psychology and Neuroscience, King's College London, United Kingdom.; Ambler A; Social, Genetic & Developmental Psychiatry Center, Institute of Psychiatry, Psychology and Neuroscience, King's College London, United Kingdom; Dunedin Multidisciplinary Health and Development Unit, University of Otago, New Zealand.; Arseneault L; Social, Genetic & Developmental Psychiatry Center, Institute of Psychiatry, Psychology and Neuroscience, King's College London, United Kingdom.; Belsky DW; Columbia University Mailman School of Public Health, New York.; Danese A; Social, Genetic & Developmental Psychiatry Center, Institute of Psychiatry, Psychology and Neuroscience, King's College London, United Kingdom; Institute of Psychiatry, Psychology and Neuroscience, King's College London, United Kingdom; National & Specialist CAMHS Clinic for Trauma, Anxiety and Depression, South London & Maudsley NHS Foundation Trust, London, United Kingdom.; Fisher HL; Social, Genetic & Developmental Psychiatry Center, Institute of Psychiatry, Psychology and Neuroscience, King's College London, United Kingdom.; Matthews T; Social, Genetic & Developmental Psychiatry Center, Institute of Psychiatry, Psychology and Neuroscience, King's College London, United Kingdom.; Richmond-Rakerd LS; Duke University, Durham, North Carolina; Frank Porter Graham Child Development Institute, University of North Carolina, Chapel Hill.; Moffitt TE; Duke University, Durham, North Carolina; Duke University Medical Center, Durham, North Carolina; Social, Genetic & Developmental Psychiatry Center, Institute of Psychiatry, Psychology and Neuroscience, King's College London, United Kingdom.
Source
Publisher: Elsevier Country of Publication: United States NLM ID: 8704565 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1527-5418 (Electronic) Linking ISSN: 08908567 NLM ISO Abbreviation: J Am Acad Child Adolesc Psychiatry Subsets: MEDLINE
Subject
Language
English
Abstract
Objective: Borderline personality disorder in adolescence remains a controversial construct. We addressed concerns about the prognostic significance of adolescent borderline pathology by testing whether borderline symptoms at age 12 years predict functioning during the transition to adulthood, at age 18 years, in areas critical to life-course development.
Method: We studied members of the Environmental Risk (E-Risk) Longitudinal Twin Study, which tracks the development of a birth cohort of 2,232 British twin children. At age 12, study members' borderline symptoms were measured using mothers' reports. At age 18, study members' personality, psychopathology, functional outcomes, and experiences of victimization were measured using self-reports, coinformant reports, and official records.
Results: At age 18, study members who had more borderline symptoms at age 12 were more likely to have difficult personalities, to struggle with poor mental health, to experience poor functional outcomes, and to have become victims of violence. Reports of poor outcomes were corroborated by coinformants and official records. Borderline symptoms in study members at 12 years old predicted poor outcomes over and above other behavioral and emotional problems during adolescence. Twin analyses showed that borderline symptoms in 12-year-olds were influenced by familial risk, particularly genetic risk, which accounted for associations with most poor outcomes at age 18.
Conclusion: Borderline symptoms in 12-year-olds signal risk for pervasive poor functioning during the transition to adulthood. This association is driven by genetic influences, suggesting that borderline symptoms and poor outcomes are manifestations of shared genetic risk.
(Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.)
Method: We studied members of the Environmental Risk (E-Risk) Longitudinal Twin Study, which tracks the development of a birth cohort of 2,232 British twin children. At age 12, study members' borderline symptoms were measured using mothers' reports. At age 18, study members' personality, psychopathology, functional outcomes, and experiences of victimization were measured using self-reports, coinformant reports, and official records.
Results: At age 18, study members who had more borderline symptoms at age 12 were more likely to have difficult personalities, to struggle with poor mental health, to experience poor functional outcomes, and to have become victims of violence. Reports of poor outcomes were corroborated by coinformants and official records. Borderline symptoms in study members at 12 years old predicted poor outcomes over and above other behavioral and emotional problems during adolescence. Twin analyses showed that borderline symptoms in 12-year-olds were influenced by familial risk, particularly genetic risk, which accounted for associations with most poor outcomes at age 18.
Conclusion: Borderline symptoms in 12-year-olds signal risk for pervasive poor functioning during the transition to adulthood. This association is driven by genetic influences, suggesting that borderline symptoms and poor outcomes are manifestations of shared genetic risk.
(Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.)