학술논문

Genome-wide meta-analyses reveal novel loci for verbal short-term memory and learning.
Document Type
Academic Journal
Author
Lahti J; Department of Psychology and Logopedics, University of Helsinki, Helsinki, Finland. jari.lahti@helsinki.fi.; Turku Institute of Advanced Studies, University of Turku, Turku, Finland. jari.lahti@helsinki.fi.; Tuominen S; Department of Psychology and Logopedics, University of Helsinki, Helsinki, Finland.; Yang Q; Department of Biostatistics, Boston University, Boston, MA, USA.; Pergola G; Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA.; Department of Basic Medical Science, Neuroscience, and Sense Organs, University of Bari Aldo Moro, Bari, Italy.; Ahmad S; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.; Amin N; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.; Armstrong NJ; Department of Mathematics and Statistics, Murdoch University, Murdoch, WA, Australia.; Beiser A; Department of Biostatistics, Boston University, Boston, MA, USA.; Framingham Heart Study, Framingham, MA, USA.; Bey K; Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany.; German Center for Neurodegenerative Diseases, Bonn, Germany.; Bis JC; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.; Boerwinkle E; Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA.; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.; Bressler J; Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA.; Campbell A; Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.; Usher Institute, University of Edinburgh, Edinburgh, UK.; Campbell H; Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK.; Chen Q; Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA.; Corley J; Department of Psychology, Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.; Cox SR; Department of Psychology, Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.; Davies G; Department of Psychology, Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.; De Jager PL; Center for Translational and Computational Neuroimmunology, Columbia University Medical Center, New York, NY, USA.; Derks EM; Translational Neurogenomics Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.; Faul JD; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.; Fitzpatrick AL; Department of Family Medicine, University of Washington, Seattle, WA, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Department of Global Health, University of Washington, Seattle, WA, USA.; Fohner AE; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Institute of Public Health Genetics, University of Washington, Seattle, WA, USA.; Ford I; Robertson Center for Biostatistics, University of Glasgow, Glasgow, UK.; Fornage M; McGovern Medical School, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA.; Gerring Z; Translational Neurogenomics Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.; Grabe HJ; Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.; German Center for Neurodegenerative Diseases, Greifswald, Germany.; Grodstein F; Channing Laboratory, Brigham and Women's Hospital, Boston, MA, USA.; Harvard School of Public Health, Boston, MA, USA.; Gudnason V; Icelandic Heart Assocation, Kopavogur, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland.; Simonsick E; Translational Gerontology Branch, National Institute on Aging, Intramural Research Program, National Institutes of Health, Baltimore, MD, USA.; Holliday EG; School of Medicine and Public Health, University of Newcastle, Callaghan, NSW, Australia.; Joshi PK; Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK.; Institute of Social and Preventive Medicine, University of Lausanne, Lausanne, Switzerland.; Kajantie E; National Institute for Health and Welfare, Helsinki and Oulu, Oulu, Finland.; Hospital for Children and Adolescents, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.; PEDEGO Research Unit, MRC Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland.; Kaprio J; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.; Department of Public Health, University of Helsinki, Helsinki, Finland.; Karell P; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.; Kleineidam L; German Center for Neurodegenerative Diseases, Bonn, Germany.; Department for Neurodegenerative Diseases and Geriatric Psychiatry, University of Bonn, Bonn, Germany.; Knol MJ; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.; Kochan NA; Centre for Healthy Brain Ageing (CHeBA), School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.; Neuropsychiatric Institute, Prince of Wales Hospital, Sydney, NSW, Australia.; Kwok JB; Brain and Mind Centre, The University of Sydney, Sydney, NSW, Australia.; School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia.; Leber M; Department of Psychiatry, University of Cologne, Cologne, Germany.; Lam M; Psychiatry Research, Zucker Hillside Hospital, Glen Oaks, NY, USA.; Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA.; Lee T; Centre for Healthy Brain Ageing (CHeBA), School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.; Neuropsychiatric Institute, Prince of Wales Hospital, Sydney, NSW, Australia.; Li S; Department of Biostatistics, Boston University, Boston, MA, USA.; Loukola A; Helsinki Biobank, University of Helsinki Central Hospital, Helsinki, Finland.; Luck T; Department of Economic and Social Sciences & Institute of Social Medicine, Rehabilitation Sciences and Healthcare Research, University of Applied Sciences Nordhausen, Nordhausen, Germany.; University of Leipzig, Leipzig, Germany.; LIFE Leipzig Research Center for Civilization Diseases, Leipzig, Germany.; Marioni RE; Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.; Mather KA; Centre for Healthy Brain Ageing (CHeBA), School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.; Sunnybrook Health Sciences Centre, University of Toronto, Randwick, NSW, Australia.; Medland S; QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.; Mirza SS; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.; Department of Neurology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada.; Nalls MA; Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD, USA.; Data Tecnica International, Glen Echo, MD, USA.; Nho K; Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA.; Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, IN, USA.; Indiana Alzheimer Disease Center, Indiana University School of Medicine, Indianapolis, IN, USA.; O'Donnell A; Department of Biostatistics, Boston University, Boston, MA, USA.; Framingham Heart Study, Framingham, MA, USA.; Oldmeadow C; Clinical Research Design, IT and Statistical Support Unit, Hunter Medical Research Institute, New Lambton, NSW, Australia.; Painter J; QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.; Pattie A; Department of Psychology, Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.; Reppermund S; Centre for Healthy Brain Ageing (CHeBA), School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.; Department of Developmental Disability Neuropsychiatry, School of Psychiatry, University of New South Wales, Sydney, NSW, Australia.; Risacher SL; Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA.; Indiana Alzheimer Disease Center, Indiana University School of Medicine, Indianapolis, IN, USA.; Rose RJ; Department of Psychological & Brain Sciences, Indiana University Bloomington, Bloomington, IN, USA.; Sadashivaiah V; Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA.; Scholz M; Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany.; LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany.; Satizabal CL; Framingham Heart Study, Framingham, MA, USA.; Department of Neurology, Boston University, Boston, MA, USA.; Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX, USA.; Schofield PW; Neuropsychiatry Service, Hunter New England Local Health District, Charlestown, NSW, Australia.; Schraut KE; Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK.; Centre for Cardiovascular Sciences, Queen's Medical Research Institute, Royal Infirmary of Edinburgh, University of Edinburgh, Edinburgh, UK.; Scott RJ; School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, NSW, Australia.; Hunter Medical Research Institute, New Lambton, NSW, Australia.; Simino J; Department of Data Science, University of Mississippi Medical Center, Jackson, MS, USA.; Smith AV; Icelandic Heart Assocation, Kopavogur, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland.; Smith JA; Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA.; Institute of Social Research, Survey Research Center, University of Michigan, Ann Arbor, MI, USA.; Stott DJ; Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.; Surakka I; Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.; Teumer A; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.; Thalamuthu A; Centre for Healthy Brain Ageing (CHeBA), School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.; Trompet S; Section of Gerontology and Geriatrics, Department of Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands.; Turner ST; Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA.; van der Lee SJ; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.; Department of Neurology and Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands.; Villringer A; Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.; Day Clinic for Cognitive Neurology, University Hospital Leipzig, Leipzig, Germany.; Völker U; Interfaculty Institute for Genetics and Functional Genomics, Department Functional Genomics, University Medicine Greifswald, Greifswald, Germany.; Wilson RS; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.; Wittfeld K; Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.; German Center for Neurodegenerative Diseases, Greifswald, Germany.; Vuoksimaa E; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.; Xia R; Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA.; Yaffe K; Department of Psychiatry, University of California, San Francisco, CA, USA.; Yu L; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.; Zare H; Department of Cell Systems & Anatomy, The University of Texas Health Science Center, San Antonio, TX, USA.; Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, University of Texas, San Antonio, TX, USA.; University of Texas Health Sciences Center, Houston, NA, US.; Zhao W; Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA.; Ames D; National Ageing Research Institute, Parkville, Melbourne, VIC, Australia.; University of Melbourne, Academic Unit for Psychiatry of Old Age, St George's Hospital, Melbourne, VIC, Australia.; Attia J; School of Medicine and Public Health, University of Newcastle, Callaghan, NSW, Australia.; Clinical Research Design, IT and Statistical Support Unit, Hunter Medical Research Institute, New Lambton, NSW, Australia.; Bennett DA; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.; Brodaty H; Centre for Healthy Brain Ageing (CHeBA), School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.; Dementia Collaborative Research Centre, University of New South Wales, Sydney, NSW, Australia.; Chasman DI; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Goldman AL; Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA.; Hayward C; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.; Ikram MA; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.; Jukema JW; Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.; Kardia SLR; Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA.; Lencz T; Hofstra Northwell School of Medicine, Hempstead, NY, USA.; Loeffler M; Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany.; LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany.; Mattay VS; Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA.; Food and Drug Administration, Washington, DC, USA.; Palotie A; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.; Analytic and Translational Genetics Unit, Department of Medicine, Department of Neurology and Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.; The Stanley Center for Psychiatric Research and Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Psaty BM; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.; Department of Epidemiology and Department of Health Services, University of Washington, Seattle, WA, USA.; Kaiser Permanente Washington Heath Research Institute, Seattle, WA, USA.; Ramirez A; Department for Neurodegenerative Diseases and Geriatric Psychiatry, University of Bonn, Bonn, Germany.; Department of Psychiatry, University of Cologne, Cologne, Germany.; Ridker PM; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Riedel-Heller SG; Institute of Social Medicine, Occupational Health and Public Health, University of Leipzig, Leipzig, Germany.; Sachdev PS; Centre for Healthy Brain Ageing (CHeBA), School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.; Neuropsychiatric Institute, Prince of Wales Hospital, Sydney, NSW, Australia.; Saykin AJ; Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA.; Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, IN, USA.; Indiana Alzheimer Disease Center, Indiana University School of Medicine, Indianapolis, IN, USA.; Scherer M; Institute of Primary Medical Care, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Schofield PR; School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia.; Neuroscience Research Australia, Randwick, NSW, Australia.; Sidney S; Kaiser Permanente Northern California, Division of Research, Oakland, CA, USA.; Starr JM; Department of Psychology, Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.; Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, UK.; Trollor J; Centre for Healthy Brain Ageing (CHeBA), School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.; Department of Developmental Disability Neuropsychiatry, School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.; Ulrich W; Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA.; Wagner M; German Center for Neurodegenerative Diseases, Bonn, Germany.; Department for Neurodegenerative Diseases and Geriatric Psychiatry, University of Bonn, Bonn, Germany.; Weir DR; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.; Wilson JF; Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK.; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.; Wright MJ; Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia.; Centre for Advanced Imaging, The University of Queensland, Brisbane, QLD, Australia.; Weinberger DR; Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA.; Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Debette S; Inserm, Bordeaux Population Health Research Center, team VINTAGE, UMR 1219, University of Bordeaux, Bordeaux, France.; Bordeaux University Hospital (CHU Bordeaux), Department of Neurology, Bordeaux, France.; Eriksson JG; Folkhälsan Research Center, Helsinki, Finland.; Department of General Practice and Primary Health Care, University of Helsinki, and Helsinki University Hospital, University of Helsinki, Helsinki, Finland.; Department of Obstetrics & Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Helsinki, Singapore.; Mosley TH Jr; Department of Medicine, Division of Geriatrics, University of Mississippi Medical Center, Jackson, MS, USA.; Launer LJ; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, National Institutes of Health, Bethesda, MD, USA.; van Duijn CM; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.; Department of Public Health, Oxford University, Oxford, UK.; Deary IJ; Department of Psychology, Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.; Seshadri S; Framingham Heart Study, Framingham, MA, USA.; Department of Neurology, Boston University, Boston, MA, USA.; Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX, USA.; Räikkönen K; Department of Psychology and Logopedics, University of Helsinki, Helsinki, Finland.
Source
Publisher: Nature Publishing Group Specialist Journals Country of Publication: England NLM ID: 9607835 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5578 (Electronic) Linking ISSN: 13594184 NLM ISO Abbreviation: Mol Psychiatry Subsets: MEDLINE
Subject
Language
English
Abstract
Understanding the genomic basis of memory processes may help in combating neurodegenerative disorders. Hence, we examined the associations of common genetic variants with verbal short-term memory and verbal learning in adults without dementia or stroke (N = 53,637). We identified novel loci in the intronic region of CDH18, and at 13q21 and 3p21.1, as well as an expected signal in the APOE/APOC1/TOMM40 region. These results replicated in an independent sample. Functional and bioinformatic analyses supported many of these loci and further implicated POC1. We showed that polygenic score for verbal learning associated with brain activation in right parieto-occipital region during working memory task. Finally, we showed genetic correlations of these memory traits with several neurocognitive and health outcomes. Our findings suggest a role of several genomic loci in verbal memory processes.
(© 2022. The Author(s).)