학술논문
[Interpretation on Consensus on drug-induced liver injury by CIOMS Working Group:liver injury attributed to herbal and dietary supplements].
Document Type
Academic Journal
Author
Jing J; Fifth Medical Center of Chinese PLA General Hospital Beijing 100039, China.; Wang RL; Fifth Medical Center of Chinese PLA General Hospital Beijing 100039, China.; Bai ZF; Fifth Medical Center of Chinese PLA General Hospital Beijing 100039, China.; Guo YM; Fifth Medical Center of Chinese PLA General Hospital Beijing 100039, China.; He TT; Fifth Medical Center of Chinese PLA General Hospital Beijing 100039, China.; Wang JB; School of Traditional Chinese Medicine, Capital Medical University Beijing 100069, China.; Song HB; Center for Drug Reevaluation, National Medical Products Administration Beijing 100022, China.; Xiao XH; Fifth Medical Center of Chinese PLA General Hospital Beijing 100039, China.
Source
Publisher: Zhongguo yao xue hui : Zhongguo Zhong yi yan jiu yuan Zhong yao yan jiu suo Country of Publication: China NLM ID: 8913656 Publication Model: Print Cited Medium: Print ISSN: 1001-5302 (Print) Linking ISSN: 10015302 NLM ISO Abbreviation: Zhongguo Zhong Yao Za Zhi Subsets: MEDLINE
Subject
Language
Chinese
ISSN
1001-5302
Abstract
With the increase in the medical level, the improvement of adverse drug reaction(ADR) monitoring systems, and the enhancement of public awareness of safe medication, drug safety incidents have been frequently reported. Drug-induced liver injury(DILI), especially liver injury attributed to herbal and dietary supplements(HDS), has globally attracted high attention, bringing great threats and severe challenges to the people for drug safety management such as clinical medication and medical supervision. Consensus on drug-induced liver injury had been published by the Council for International Organizations of Medical Sciences(CIOMS) in 2020. In this consensus, liver injury attributed to HDS was included in a special chapter for the first time. The hot topics, including the definition of HDS-induced liver injury, epidemiological history, potential risk factors, collection of related risk signals, causality assessment, risk prevention, control and management were discussed from a global perspective. Based on the previous works, some experts from China were invited by CIOMS to undertake the compilation of this chapter. Meanwhile, a new causality assessment in DILI based on the integrated evidence chain(iEC) method was widely recognized by experts in China and abroad, and was recommended by this consensus. This paper briefly introduced the main contents, background, and characteristics of the Consensus on drug-induced liver injury. Significantly, a brief interpretation was illustrated to analyze the special highlights of Chapter 8, "Liver injury attributed to HDS", so as to provide practical references for the medical staff and the researchers who worked on either Chinese or Western medicine in China.