학술논문
Dietary mineral intakes predict Coronavirus-disease 2019 (COVID-19) incidence and hospitalization in older adults.
Document Type
Academic Journal
Author
Seifi N; International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran.; Department of Nutrition, Medical School, Mashhad University of Medical Sciences, Mashhad, Iran.; Bahari H; Transplant Research Center, Clinical Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran.; Ghiasi Hafezi S; International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran.; Ghotbani F; Student Research committee, Mashhad University of Medical Sciences, Mashhad, Iran.; Afzalinia A; Department of Biology, Mashhad Branch, Islamic Azad University, Mashhad, Iran.; Ferns GA; Brighton & Sussex Medical School, Division of Medical Education, Falmer, Brighton, Sussex, UK.; Farkhani EM; Deputy of Health, Mashhad University of Medical Sciences, Mashhad, Iran.; Ghayour-Mobarhan M; International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran. Ghayourmobarhan@yahoo.com.; Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. Ghayourmobarhan@yahoo.com.
Source
Publisher: BioMed Central Country of Publication: England NLM ID: 101672434 Publication Model: Electronic Cited Medium: Internet ISSN: 2055-0928 (Electronic) Linking ISSN: 20550928 NLM ISO Abbreviation: BMC Nutr Subsets: PubMed not MEDLINE
Subject
Language
English
Abstract
Background: The aim of this study was to determine the association between dietary mineral intake and Coronavirus-disease 2019 (COVID-19) infection and its associated hospitalization.
Methods: This cohort study utilized the MASHAD study population, which comprised individuals aged 35-65. Upon recruitment in 2007, dietary intake was documented using a validated 65-item food frequency questionnaire (FFQ). Data on COVID-19 PCR test results was collected from all relevant medical centers in Mashhad between February 2020 and June 2022. The regression model included dietary minerals and employed the backward variable selection method, along with advanced data analysis techniques.
Results: The final analysis involved 1957 participants, including 193 COVID-19-positive patients. The mean age was 49.71 and 50.28 years in the COVID-19-positive and negative groups, respectively (p = 0.12). Dietary intakes of magnesium, iron, and potassium were notably lower in COVID-19-positive patients (P < 0.05). Following adjustments for age and sex, dietary iron remained significantly associated with COVID-19 incidence (OR = 0.94, 95% CI: 0.90-0.98). Furthermore, a statistically significant relationship was observed between dietary zinc and hospitalization due to COVID-19 (OR = 0.69, 95% CI: 0.51-0.93). In dynamical system models, intakes of calcium, zinc, and iron below the cut-offs of 1138, 9.7, and 8.17 mg/day, respectively, were linked to an increased risk of COVID-19 incidence.
Conclusion: Higher dietary iron and zinc intake are associated with decreased risk of COVID-19 infection and hospitalization, respectively.
(© 2024. The Author(s).)
Methods: This cohort study utilized the MASHAD study population, which comprised individuals aged 35-65. Upon recruitment in 2007, dietary intake was documented using a validated 65-item food frequency questionnaire (FFQ). Data on COVID-19 PCR test results was collected from all relevant medical centers in Mashhad between February 2020 and June 2022. The regression model included dietary minerals and employed the backward variable selection method, along with advanced data analysis techniques.
Results: The final analysis involved 1957 participants, including 193 COVID-19-positive patients. The mean age was 49.71 and 50.28 years in the COVID-19-positive and negative groups, respectively (p = 0.12). Dietary intakes of magnesium, iron, and potassium were notably lower in COVID-19-positive patients (P < 0.05). Following adjustments for age and sex, dietary iron remained significantly associated with COVID-19 incidence (OR = 0.94, 95% CI: 0.90-0.98). Furthermore, a statistically significant relationship was observed between dietary zinc and hospitalization due to COVID-19 (OR = 0.69, 95% CI: 0.51-0.93). In dynamical system models, intakes of calcium, zinc, and iron below the cut-offs of 1138, 9.7, and 8.17 mg/day, respectively, were linked to an increased risk of COVID-19 incidence.
Conclusion: Higher dietary iron and zinc intake are associated with decreased risk of COVID-19 infection and hospitalization, respectively.
(© 2024. The Author(s).)