학술논문
It's not what you say, it's how you say it: A retrospective study of the impact of prosody on own-name P300 in comatose patients.
Document Type
Academic Journal
Author
Pruvost-Robieux E; Neurophysiology Department, GHU Paris Psychiatrie et Neurosciences, Sainte Anne Hospital, Paris, France; Université de Paris, Institut Paris Neurosciences et Psychiatrie IPNP (INSERM / Université de Paris), Paris, France; Science and Technology of Music and Sound Lab (IRCAM/CNRS/Sorbonne Université), Paris, France. Electronic address: e.pruvost@ghu-paris.fr.; André-Obadia N; Neurophysiology Department, Hôpital Neurologique Pierre Wertheimer, Bron, France.; Marchi A; Neurophysiology Department, GHU Paris Psychiatrie et Neurosciences, Sainte Anne Hospital, Paris, France.; Sharshar T; Intensive care unit, GHU Paris Psychiatrie et Neurosciences, Sainte Anne Hospital, Paris, France; Université de Paris, Institut Paris Neurosciences et Psychiatrie IPNP (INSERM / Université de Paris), Paris, France.; Liuni M; Alta Voce SAS, Houilles, France.; Gavaret M; Neurophysiology Department, GHU Paris Psychiatrie et Neurosciences, Sainte Anne Hospital, Paris, France; Université de Paris, Institut Paris Neurosciences et Psychiatrie IPNP (INSERM / Université de Paris), Paris, France.; Aucouturier JJ; FEMTO-ST Institute (CNRS/Université de Bourgogne Franche Comté), Besançon, France.
Source
Publisher: Elsevier Country of Publication: Netherlands NLM ID: 100883319 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-8952 (Electronic) Linking ISSN: 13882457 NLM ISO Abbreviation: Clin Neurophysiol Subsets: MEDLINE
Subject
Language
English
Abstract
Objective: The acoustic characteristics of stimuli influence the characteristics of the corresponding evoked potentials in healthy subjects. Own-name stimuli are used in clinical practice to assess the level of consciousness in intensive care units. The influence of the acoustic variability of these stimuli has never been evaluated. Here, we explored the influence of this variability on the characteristics of the subject's own name (SON) P300.
Methods: We retrospectively analyzed 251 disorders of consciousness patients from Lyon and Paris Hospitals who underwent an "own-name protocol". A reverse correlation analysis was performed to test for an association between acoustic properties of own-names stimuli used and the characteristics of the P300 wave observed.
Results: Own-names pronounced with increasing pitch prosody showed P300 responses 66 ms earlier than own-names that had a decreasing prosody [IC95% = 6.36; 125.9 ms].
Conclusions: Speech prosody of the stimuli in the "own name protocol" is associated with latencies differences of the P300 response among patients for whom these responses were observed. Further investigations are needed to confirm these results.
Significance: Speech prosody of the stimuli in the "own name protocol" is a non-negligible parameter, associated with P300 latency differences. Speech prosody should be standardized in SON P300 studies.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2022 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.)
Methods: We retrospectively analyzed 251 disorders of consciousness patients from Lyon and Paris Hospitals who underwent an "own-name protocol". A reverse correlation analysis was performed to test for an association between acoustic properties of own-names stimuli used and the characteristics of the P300 wave observed.
Results: Own-names pronounced with increasing pitch prosody showed P300 responses 66 ms earlier than own-names that had a decreasing prosody [IC
Conclusions: Speech prosody of the stimuli in the "own name protocol" is associated with latencies differences of the P300 response among patients for whom these responses were observed. Further investigations are needed to confirm these results.
Significance: Speech prosody of the stimuli in the "own name protocol" is a non-negligible parameter, associated with P300 latency differences. Speech prosody should be standardized in SON P300 studies.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2022 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.)