학술논문
Incidence and Risk Factors of Venous Thromboembolic Events in Patients with ANCA-Glomerulonephritis: A Cohort Study from the Maine-Anjou Registry.
Document Type
Academic Journal
Author
Henry N; Service de Néphrologie-Dialyse-Transplantation, Université d'Angers, CHU Angers, 4 rue Larrey, 49033 Angers CEDEX 09, France.; Brilland B; Service de Néphrologie-Dialyse-Transplantation, Université d'Angers, CHU Angers, 4 rue Larrey, 49033 Angers CEDEX 09, France.; CHU d'Angers, Université d'Angers, INSERM U1232, CRCINA, 49000 Angers, France.; Wacrenier S; Service de Néphrologie-Dialyse-Transplantation, Université d'Angers, CHU Angers, 4 rue Larrey, 49033 Angers CEDEX 09, France.; Service de Néphrologie-Dialyse, CH du Mans, 72000 Le Mans, France.; Djema A; Service de Néphrologie-Dialyse, CH de Cholet, 49300 Cholet, France.; Garnier AS; Service de Néphrologie-Dialyse-Transplantation, Université d'Angers, CHU Angers, 4 rue Larrey, 49033 Angers CEDEX 09, France.; Gansey R; Service de Néphrologie-Dialyse, CH de Laval, 53000 Laval, France.; Coindre JP; Service de Néphrologie-Dialyse, CH du Mans, 72000 Le Mans, France.; Besson V; Service de Néphrologie-Dialyse-Transplantation, Université d'Angers, CHU Angers, 4 rue Larrey, 49033 Angers CEDEX 09, France.; Duveau A; Service de Néphrologie-Dialyse-Transplantation, Université d'Angers, CHU Angers, 4 rue Larrey, 49033 Angers CEDEX 09, France.; Subra JF; Service de Néphrologie-Dialyse-Transplantation, Université d'Angers, CHU Angers, 4 rue Larrey, 49033 Angers CEDEX 09, France.; CHU d'Angers, Université d'Angers, INSERM U1232, CRCINA, 49000 Angers, France.; Cousin M; Service de Néphrologie-Dialyse-Transplantation, Université d'Angers, CHU Angers, 4 rue Larrey, 49033 Angers CEDEX 09, France.; Piccoli GB; Service de Néphrologie-Dialyse, CH du Mans, 72000 Le Mans, France.; Augusto JF; Service de Néphrologie-Dialyse-Transplantation, Université d'Angers, CHU Angers, 4 rue Larrey, 49033 Angers CEDEX 09, France.; CHU d'Angers, Université d'Angers, INSERM U1232, CRCINA, 49000 Angers, France.
Source
Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101606588 Publication Model: Electronic Cited Medium: Print ISSN: 2077-0383 (Print) Linking ISSN: 20770383 NLM ISO Abbreviation: J Clin Med Subsets: PubMed not MEDLINE
Subject
Language
English
ISSN
2077-0383
Abstract
(1) Introduction: The incidence of venous thromboembolisms (VTE) has not been extensively analyzed in patients with antineutrophil cytoplasmic antibody (ANCA)-glomerulonephritis (ANCA-GN). Thus, the aim of the present study was to assess the frequency and the risk factors of VTE in patients with ANCA-GN. (2) Methods: Patients from the Maine-Anjou ANCA-associated vasculitis (AAV) registry with a biopsy showing pauci-immune glomerulonephritis were included. VTE events, site, and interval from AAV diagnosis were analyzed. (3) Results: 133 patients fulfilled the inclusion criteria of the study and were analyzed. VTE episodes were diagnosed in 23/133 (17.3%) patients at a median delay of 3 months from ANCA-GN diagnosis. Patients with VTE had lower serum albumin ( p = 0.040), were less frequently on statin therapy ( p = 0.009) and had less frequently proteinase-3 (PR3)-ANCAs ( p = 0.078). Univariate analysis identified higher age ( p = 0.022), lower serum albumin ( p = 0.030), lack of statin therapy ( p = 0.009), and rituximab treatment ( p = 0.018) as significant risk factors of VTE. In multivariate analysis, only lack of statin therapy (HR 4.873; p = 0.042) was significantly associated with VTE. (4) Conclusion: Patients with ANCA-GN are at high risk of VTE, especially within the first months following AAV diagnosis. Our results suggest that statin therapy is associated with a lower risk of VTE in ANCA-GN patients.