학술논문
Regulation of drug release from polymer matrices by oscillating magnetic fields.
Document Type
Academic Journal
Author
Source
Publisher: Wiley Country of Publication: United States NLM ID: 0112726 Publication Model: Print Cited Medium: Print ISSN: 0021-9304 (Print) Linking ISSN: 00219304 NLM ISO Abbreviation: J Biomed Mater Res Subsets: MEDLINE
Subject
Language
English
ISSN
0021-9304
Abstract
The reproducible regulation of release of a macromolecule (bovine serum albumin) from biocompatible polymer systems has been demonstrated. Small magnetic spheres or cylindrical magnets were embedded within the polymer matrix which was then subjected to an oscillating magnetic field. In this fashion baseline release rates could be increased 5- to 10-fold with 5-10% standard error. Parameters critical to the regulation of this release included the position, orientation, and magnetic strength of the embedded objects and the amplitude and frequency of the applied magnetic field. Scanning electronmicrographs of the polymer matrix surface reveal that a gap, approximately 100/microns wide, is formed between the embedded object and adjacent polymer material after repeated exposure to an oscillating magnetic field.