학술논문
The transcription factor ZEB1 (deltaEF1) represses Plakophilin 3 during human cancer progression.
Document Type
Academic Journal
Author
Aigner K; Max F. Perutz Laboratories, Department of Medical Biochemistry, Medical University Vienna, Dr. Bohrgasse 9, A-1030 Vienna, Austria.; Descovich L; Mikula M; Sultan A; Dampier B; Bonné S; van Roy F; Mikulits W; Schreiber M; Brabletz T; Sommergruber W; Schweifer N; Wernitznig A; Beug H; Foisner R; Eger A
Source
Publisher: John Wiley & Sons Ltd Country of Publication: England NLM ID: 0155157 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0014-5793 (Print) Linking ISSN: 00145793 NLM ISO Abbreviation: FEBS Lett Subsets: MEDLINE
Subject
Language
English
ISSN
0014-5793
Abstract
Plakophilin 3 (PKP3) belongs to the p120ctn family of armadillo-related proteins predominantly functioning in desmosome formation. Here we report that PKP3 is transcriptionally repressed by the E-cadherin repressor ZEB1 in metastatic cancer cells. ZEB1 physically associates with two conserved E-box elements in the PKP3 promoter and partially represses the activity of corresponding human and mouse PKP3 promoter fragments in reporter gene assays. In human tumours ZEB1 is upregulated in invasive cancer cells at the tumour-host interface, which is accompanied by downregulation of PKP3 expression levels. Hence, the transcriptional repression of PKP3 by ZEB1 contributes to ZEB1-mediated disintegration of intercellular adhesion and epithelial to mesenchymal transition.