학술논문
Clonal haematopoiesis of indeterminate potential in patients with venous thromboembolism.
Document Type
Academic Journal
Author
Guillotin F; Department of Haematology, University Hospital of Nîmes, Nîmes, France.; Mercier É; Department of Haematology, University Hospital of Nîmes, Nîmes, France.; Faculty of Pharmaceutical and Biological Sciences, University of Montpellier, Montpellier, France.; Institut Desbrest d'Epidémiologie et de Santé Publique UMR INSERM, Montpellier, France.; Fortier M; Department of Haematology, University Hospital of Nîmes, Nîmes, France. mathieu.fortier@chu-nimes.fr.; Bouvier S; Department of Haematology, University Hospital of Nîmes, Nîmes, France.; Faculty of Pharmaceutical and Biological Sciences, University of Montpellier, Montpellier, France.; Institut Desbrest d'Epidémiologie et de Santé Publique UMR INSERM, Montpellier, France.; Jacquet Q; Department of Haematology, University Hospital of Nîmes, Nîmes, France.; Dallo M; Department of Haematology, University Hospital of Nîmes, Nîmes, France.; Chéa M; Department of Haematology, University Hospital of Nîmes, Nîmes, France.; Bourguignon C; Department of Haematology, University Hospital of Nîmes, Nîmes, France.; Institut Desbrest d'Epidémiologie et de Santé Publique UMR INSERM, Montpellier, France.; Cochery-Nouvellon É; Department of Haematology, University Hospital of Nîmes, Nîmes, France.; Perez-Martin A; Institut Desbrest d'Epidémiologie et de Santé Publique UMR INSERM, Montpellier, France.; Department of Vascular Medicine, University Hospital of Nîmes, Nîmes, France.; Gris JC; Department of Haematology, University Hospital of Nîmes, Nîmes, France.; Faculty of Pharmaceutical and Biological Sciences, University of Montpellier, Montpellier, France.; Institut Desbrest d'Epidémiologie et de Santé Publique UMR INSERM, Montpellier, France.; I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation.
Source
Publisher: Kluwer Academic Publishers Country of Publication: Netherlands NLM ID: 9502018 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-742X (Electronic) Linking ISSN: 09295305 NLM ISO Abbreviation: J Thromb Thrombolysis Subsets: MEDLINE
Subject
Language
English
Abstract
Over the last decade, the concept of Clonal haematopoiesis of undetermined potential (CHIP) has emerged. Low frequency somatic mutations in hematopoietic cells can occur with age and might allow formation of clones in individuals with no characterized haematological pathology. These CHIP mutations are associated with an increased risk of cancer or atherothrombosis, and their prevalence are more and more studied in pathologies with an inflammatory component. In our study, we analysed, by next generation sequencing, the prevalence of CHIP mutation in 94 patients with deep venous thrombosis (DVT), distinguishing two clinical phenotypes: provoked distal and non-provoked proximal DVTs. We show that there is no difference in CHIP prevalence between these two groups, nor with a matched-aged control group. The number of mutation per patients and the affected genes remain also the same between the three groups. Consequently and despite the relative small number of patients in each cohort, it seems that CHIP is not a strong concern in venous thromboembolism.
(© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
(© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)