학술논문
EANM practice guidelines for an appropriate use of PET and SPECT for patients with epilepsy.
Document Type
Academic Journal
Author
Traub-Weidinger T; Division of Nuclear Medicine, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria.; Arbizu J; Department of Nuclear Medicine, University of Navarra Clinic, Pamplona, Spain.; Barthel H; Department of Nuclear Medicine, Leipzig University Medical Centre, Leipzig, Germany.; Boellaard R; Department of Radiology and Nuclear Medicine, Amsterdam UMC, Location VUmc, Amsterdam, The Netherlands.; Borgwardt L; Department of Clinical Physiology and Nuclear Medicine, University of Copenhagen, Blegdamsvej 9, DK-2100, RigshospitaletCopenhagen, Denmark.; Brendel M; Department of Nuclear Medicine, Ludwig Maximilian-University of Munich, Munich, Germany.; DZNE-German Center for Neurodegenerative Diseases, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.; Cecchin D; Nuclear Medicine Unit, Department of Medicine-DIMED, University-Hospital of Padova, Padova, Italy.; Chassoux F; Université Paris-Saclay, CEA, CNRS, Inserm, BioMaps, 91401, Orsay, France.; Fraioli F; Institute of Nuclear Medicine, University College London (UCL), London, UK.; Garibotto V; Division of Nuclear Medicine and Molecular Imaging, Geneva University Hospitals, Geneva, Switzerland.; NIMTLab, Faculty of Medicine, University of Geneva, Geneva, Switzerland.; Center for Biomedical Imaging (CIBM), Geneva, Switzerland.; Guedj E; APHM, CNRS, Centrale Marseille, Institut Fresnel, Timone Hospital, CERIMED, Nuclear Medicine Department, Aix Marseille Univ, Marseille, France.; Hammers A; School of Biomedical Engineering and Imaging Sciences, Faculty of Life Sciences and Medicine, King's College London & Guy's and St Thomas' PET Centre, King's College London, London, UK.; Law I; Department of Clinical Physiology and Nuclear Medicine, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, DK-2100, Copenhagen, Denmark.; Morbelli S; Nuclear Medicine Unit, IRCCS Ospedale Policlinico San Martino, Department of Health Sciences (DISSAL), University of Genoa, Genoa, Italy.; Tolboom N; Department of Radiology and Nuclear Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.; Van Weehaeghe D; Department of Radiology and Nuclear Medicine, Ghent University Hospital, Ghent, Belgium.; Verger A; Department of Nuclear Medicine and Nancyclotep Imaging Platform, CHRU Nancy, Université de Lorraine, IADI, INSERM U1254, Nancy, France.; Van Paesschen W; Laboratory for Epilepsy Research, KU Leuven and Department of Neurology, University Hospitals, Leuven, Belgium.; von Oertzen TJ; Depts of Neurology 1&2, Kepler University Hospital, Johannes Kepler University, Linz, Austria.; Zucchetta P; Nuclear Medicine Unit, Department of Medicine-DIMED, University-Hospital of Padova, Padova, Italy.; Semah F; Nuclear Medicine Department, University Hospital, Inserm, CHU Lille, U1172-LilNCog-Lille, F-59000, Lille, France. franck.semah@chu-lille.fr.
Source
Publisher: Springer-Verlag Berlin Country of Publication: Germany NLM ID: 101140988 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1619-7089 (Electronic) Linking ISSN: 16197070 NLM ISO Abbreviation: Eur J Nucl Med Mol Imaging Subsets: MEDLINE
Subject
Language
English
Abstract
Epilepsy is one of the most frequent neurological conditions with an estimated prevalence of more than 50 million people worldwide and an annual incidence of two million. Although pharmacotherapy with anti-seizure medication (ASM) is the treatment of choice, ~30% of patients with epilepsy do not respond to ASM and become drug resistant. Focal epilepsy is the most frequent form of epilepsy. In patients with drug-resistant focal epilepsy, epilepsy surgery is a treatment option depending on the localisation of the seizure focus for seizure relief or seizure freedom with consecutive improvement in quality of life. Beside examinations such as scalp video/electroencephalography (EEG) telemetry, structural, and functional magnetic resonance imaging (MRI), which are primary standard tools for the diagnostic work-up and therapy management of epilepsy patients, molecular neuroimaging using different radiopharmaceuticals with single-photon emission computed tomography (SPECT) and positron emission tomography (PET) influences and impacts on therapy decisions. To date, there are no literature-based praxis recommendations for the use of Nuclear Medicine (NM) imaging procedures in epilepsy. The aims of these guidelines are to assist in understanding the role and challenges of radiotracer imaging for epilepsy; to provide practical information for performing different molecular imaging procedures for epilepsy; and to provide an algorithm for selecting the most appropriate imaging procedures in specific clinical situations based on current literature. These guidelines are written and authorized by the European Association of Nuclear Medicine (EANM) to promote optimal epilepsy imaging, especially in the presurgical setting in children, adolescents, and adults with focal epilepsy. They will assist NM healthcare professionals and also specialists such as Neurologists, Neurophysiologists, Neurosurgeons, Psychiatrists, Psychologists, and others involved in epilepsy management in the detection and interpretation of epileptic seizure onset zone (SOZ) for further treatment decision. The information provided should be applied according to local laws and regulations as well as the availability of various radiopharmaceuticals and imaging modalities.
(© 2024. The Author(s).)
(© 2024. The Author(s).)