학술논문
Heterologous expression of fungal L-asparaginase: a systematic review.
Document Type
Academic Journal
Author
Rodrigues Andrade KC; Laboratory of Natural Products, Health Science School, University of Brasília, Brasília, 70910-900, Brazil.; Cordeiro de Abreu JA; Laboratory of Natural Products, Health Science School, University of Brasília, Brasília, 70910-900, Brazil.; Guimarães MB; Laboratory of Natural Products, Health Science School, University of Brasília, Brasília, 70910-900, Brazil.; Abrunhosa LS; Laboratory of Natural Products, Health Science School, University of Brasília, Brasília, 70910-900, Brazil.; Leôncio Rodrigues AL; Laboratory of Natural Products, Health Science School, University of Brasília, Brasília, 70910-900, Brazil.; Fonseca-Bazzo YM; Laboratory of Natural Products, Health Science School, University of Brasília, Brasília, 70910-900, Brazil.; Silveira D; Laboratory of Natural Products, Health Science School, University of Brasília, Brasília, 70910-900, Brazil.; Souza PM; Laboratory of Natural Products, Health Science School, University of Brasília, Brasília, 70910-900, Brazil.; Magalhães PO; Laboratory of Natural Products, Health Science School, University of Brasília, Brasília, 70910-900, Brazil.
Source
Publisher: Future Medicine Country of Publication: England NLM ID: 101278120 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1746-0921 (Electronic) Linking ISSN: 17460913 NLM ISO Abbreviation: Future Microbiol Subsets: MEDLINE
Subject
Language
English
Abstract
Aim: To review the available literature about heterologous expression of fungal L-asparaginase (L-ASNase). Materials & methods: A search was conducted across PubMed, Science Direct, Scopus and Web of Science databases; 4172 citations were identified and seven articles were selected. Results: The results showed that heterologous expression of fungal L-ASNase was performed mostly in bacterial expression systems, except for a study that expressed L-ASNase in a yeast system. Only three publications reported the purification and characterization of the enzyme. Conclusion: The information reported in this systematic review can contribute significantly to the recognition of the importance of biotechnological techniques for L-ASNase production.