학술논문
Effect of MACC1 Genetic Polymorphisms and Environmental Risk Factors in the Occurrence of Oral Squamous Cell Carcinoma.
Document Type
Academic Journal
Author
Hu RH; Department of Biomedical Sciences, Chung Shan Medical University, Taichung 402, Taiwan.; Chuang CY; School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan.; Department of Otolaryngology, Chung Shan Medical University Hospital, Taichung 402, Taiwan.; Lin CW; Institute of Oral Sciences, Chung Shan Medical University, Taichung 402, Taiwan.; Department of Dentistry, Chung Shan Medical University Hospital, Taichung 402, Taiwan.; Su SC; Whole-Genome Research Core Laboratory of Human Diseases, Chang Gung Memorial Hospital, Keelung 204, Taiwan.; Department of Dermatology, Drug Hypersensitivity Clinical and Research Center, Chang Gung Memorial Hospital, Linkou 333, Taiwan.; Chang LC; Department of Mathematical Sciences, Florida Atlantic University, Boca Raton, FL 33431, USA.; Wu SW; Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan.; Liu YF; Department of Biomedical Sciences, Chung Shan Medical University, Taichung 402, Taiwan.; Department of Pediatrics, Chung Shan Medical University Hospital, Taichung 402, Taiwan.; Yang SF; Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan.; Department of Medical Research, Chung Shan Medical University Hospital, Taichung 402, Taiwan.
Source
Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101602269 Publication Model: Electronic Cited Medium: Print ISSN: 2075-4426 (Print) Linking ISSN: 20754426 NLM ISO Abbreviation: J Pers Med Subsets: PubMed not MEDLINE
Subject
Language
English
ISSN
2075-4426
Abstract
MACC1 (Metastasis Associated in Colon Cancer 1) is found to regulate the hepatocyte growth factor (HGF)/Met signal pathway, and plays an important role in tumor proliferation, angiogenesis, and metastasis. However, the relationships between MACC1 SNPs (single nucleotide polymorphisms) and oral cancer are still blurred. In this study, five SNPs (rs3095007, rs1990172, rs4721888, rs975263, and rs3735615) were genotyped in 911 oral cancer patients and 1200 healthy individuals by real-time polymerase chain reaction (PCR), and the associations of oral cancer with the SNP genotypes, environmental risk factors, and clinicopathological characteristics were further analyzed. Our results showed that individuals who had GC genotype or C-allele (GC + CC) in rs4721888 would have a higher risk for oral cancer incidence than GG genotype after adjustment for betel quid chewing, cigarette smoking, and alcohol drinking. Moreover, the 715 oral cancer patients with a betel quid chewing habit, who had C-allele (TC + CC) in rs975263, would have a higher risk for lymph node metastasis. Further analyses of the sequences of rs4721888 revealed that the C-allele of rs4721888 would be a putative exonic splicing enhancer. In conclusion, MACC1 SNP rs4721888 would elevate the susceptibility for oral cancer, and SNP rs975263 would increase the metastasis risk for oral cancer patients with a betel quid chewing habit. Our data suggest that SNP rs4721888 could be a putative genetic marker for oral cancer, and SNP rs975362 may have the potential to be a prognostic marker of metastasis in an oral cancer patient.