학술논문
Effect of lonapalene on metabolism of exogenous arachidonic acid in human platelets.
Document Type
Academic Journal
Author
Gibert C; Unitat de Recerca Biomédica (Eicosanoids Laboratory), Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.; Vila L; Puig L; Solá J; Moragas JM
Source
Publisher: Karger Country of Publication: Switzerland NLM ID: 8810069 Publication Model: Print Cited Medium: Print ISSN: 1011-0283 (Print) Linking ISSN: 10110283 NLM ISO Abbreviation: Skin Pharmacol Subsets: MEDLINE
Subject
Language
English
ISSN
1011-0283
Abstract
Lonapalene was studied as a topical antipsoriatic agent on the basis of its inhibitory effect on 5-lipoxygenase. We studied the effect of lonapalene on the metabolism of exogenous arachidonic acid in washed platelet suspensions by RP-HPLC. Lonapalene was shown to inhibit platelet cyclooxygenase, with substrate diversion towards 12-HETE production. The pattern of inhibition was similar to that of indometacin, although lonapalene was about 1,000 times weaker. The dual inhibition of lonapalene and concomitant deviation of arachidonic acid metabolism may have potential implications, with regard to therapeutic indications and side effects, which deserve further study.