학술논문
Cohort Profile: The Barwon Infant Study.
Document Type
Academic Journal
Author
Vuillermin P; Barwon Health, Geelong, VIC, Australia, Murdoch Childrens Research Institute, Parkville, VIC, Australia, Deakin University, Geelong, VIC, Australia, University of Melbourne, Parkville, VIC, Australia, peter.vuillermin@deakin.edu.au.; Saffery R; Murdoch Childrens Research Institute, Parkville, VIC, Australia, University of Melbourne, Parkville, VIC, Australia.; Allen KJ; Murdoch Childrens Research Institute, Parkville, VIC, Australia, University of Melbourne, Parkville, VIC, Australia, Royal Children's Hospital, Parkville, VIC, Australia.; Carlin JB; Murdoch Childrens Research Institute, Parkville, VIC, Australia, University of Melbourne, Parkville, VIC, Australia.; Tang ML; Murdoch Childrens Research Institute, Parkville, VIC, Australia, University of Melbourne, Parkville, VIC, Australia, Royal Children's Hospital, Parkville, VIC, Australia.; Ranganathan S; Murdoch Childrens Research Institute, Parkville, VIC, Australia, University of Melbourne, Parkville, VIC, Australia, Royal Children's Hospital, Parkville, VIC, Australia.; Burgner D; Murdoch Childrens Research Institute, Parkville, VIC, Australia, University of Melbourne, Parkville, VIC, Australia, Department of Paediatrics, Monash University, Clayton, VIC, Australia.; Dwyer T; Murdoch Childrens Research Institute, Royal Children's Hospital, Melbourne, Victoria, Australia, The George Institute for Global Health, Oxford, United Kingdom and.; Collier F; Barwon Health, Geelong, VIC, Australia, Deakin University, Geelong, VIC, Australia.; Jachno K; Murdoch Childrens Research Institute, Parkville, VIC, Australia.; Sly P; University of Queensland, Queensland Children's Medical Research Institute, Brisbane, QLD, Australia.; Symeonides C; Barwon Health, Geelong, VIC, Australia, Murdoch Childrens Research Institute, Parkville, VIC, Australia, University of Melbourne, Parkville, VIC, Australia.; McCloskey K; Barwon Health, Geelong, VIC, Australia, Murdoch Childrens Research Institute, Parkville, VIC, Australia, Deakin University, Geelong, VIC, Australia, University of Melbourne, Parkville, VIC, Australia.; Molloy J; Barwon Health, Geelong, VIC, Australia, Murdoch Childrens Research Institute, Parkville, VIC, Australia, Deakin University, Geelong, VIC, Australia.; Forrester M; Barwon Health, Geelong, VIC, Australia, Deakin University, Geelong, VIC, Australia.; Ponsonby AL; Murdoch Childrens Research Institute, Parkville, VIC, Australia, University of Melbourne, Parkville, VIC, Australia.
Source
Publisher: Oxford University Press Country of Publication: England NLM ID: 7802871 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3685 (Electronic) Linking ISSN: 03005771 NLM ISO Abbreviation: Int J Epidemiol Subsets: MEDLINE
Subject
Language
English
Abstract
The modern environment is associated with an increasing burden of non-communicable diseases (NCDs). Mounting evidence implicates environmental exposures, experienced early in life (including in utero), in the aetiology of many NCDs, though the cellular/molecular mechanism(s) underlying this elevated risk across the life course remain unclear. Epigenetic variation has emerged as a candidate mediator of such effects. The Barwon Infant Study (BIS) is a population-derived birth cohort study (n = 1074 infants) with antenatal recruitment, conducted in the south-east of Australia (Victoria). BIS has been designed to facilitate a detailed mechanistic investigation of development within an epidemiological framework. The broad objectives are to investigate the role of specific environmental factors, gut microbiota and epigenetic variation in early-life development, and subsequent immune, allergic, cardiovascular, respiratory and neurodevelopmental outcomes. Participants have been reviewed at birth and at 1, 6, 9 and 12 months, with 2- and 4-year reviews under way. Biological samples and measures include: maternal blood, faeces and urine during pregnancy; infant urine, faeces and blood at regular intervals during the first 4 years; lung function at 1 month and 4 years; cardiovascular assessment at 1 month and 4 years; skin-prick allergy testing and food challenge at 1 year; and neurodevelopmental assessment at 9 months, 2 and 4 years. Data access enquiries can be made at [www.barwoninfantstudy.org.au] or via [peter.vuillermin@deakin.edu.au].
(© The Author 2015; all rights reserved. Published by Oxford University Press on behalf of the International Epidemiological Association.)
(© The Author 2015; all rights reserved. Published by Oxford University Press on behalf of the International Epidemiological Association.)