학술논문
Parallel profiling of immune infiltrate subsets in uveal melanoma versus cutaneous melanoma unveils similarities and differences: A pilot study.
Document Type
Academic Journal
Author
Qin Y; Department of Melanoma Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA.; Petaccia de Macedo M; Department of Translational Molecular Pathology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA.; Reuben A; Department of Surgical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA.; Forget MA; Department of Melanoma Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA.; Haymaker C; Department of Melanoma Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA.; Bernatchez C; Department of Melanoma Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA.; Spencer CN; Department of Genomic Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA.; Gopalakrishnan V; Department of Surgical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA.; Reddy S; Department of Melanoma Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA.; Cooper ZA; Department of Surgical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA.; Department of Genomic Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA.; Fulbright OJ; Department of Melanoma Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA.; Ramachandran R; Department of Melanoma Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA.; Wahl A; Department of Melanoma Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA.; Flores E; Department of Melanoma Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA.; Thorsen ST; Department of Melanoma Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA.; Tavera RJ; Department of Melanoma Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA.; Conrad C; Department of Surgical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA.; Williams MD; Department of Pathology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA.; Tetzlaff MT; Department of Translational Molecular Pathology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA.; Wang WL; Department of Translational Molecular Pathology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA.; Gombos DS; Section of Ophthalmology, Department of Head and Neck Surgery and The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA.; Esmaeli B; Orbital Oncology and Ophthalmic Plastic Surgery, Department of Plastic Surgery, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA.; Amaria RN; Department of Melanoma Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA.; Hwu P; Department of Melanoma Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA.; Wargo JA; Department of Surgical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA.; Department of Genomic Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA.; Lazar AJ; Department of Translational Molecular Pathology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA.; Patel SP; Department of Melanoma Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA.
Source
Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101570526 Publication Model: eCollection Cited Medium: Print ISSN: 2162-4011 (Print) Linking ISSN: 21624011 NLM ISO Abbreviation: Oncoimmunology Subsets: PubMed not MEDLINE
Subject
Language
English
ISSN
2162-4011
Abstract
The low response rates to immunotherapy in uveal melanoma (UM) sharply contrast with reputable response rates in cutaneous melanoma (CM) patients. To characterize the mechanisms responsible for resistance to immunotherapy in UM, we performed immune profiling in tumors from 10 metastatic UM patients and 10 metastatic CM patients by immunohistochemistry (IHC). Although there is no difference in infiltrating CD8 + T cells between UM and CM, a significant decrease in programmed death-1 (PD-1)-positive lymphocytes was observed and lower levels of programmed death ligand-1 (PD-L1) in UM metastases compared with CM metastases. Tumors from metastatic UM patients showed a lower success rate of tumor-infiltrating lymphocyte (TIL) growth compared with metastatic CM (45% vs. 64% success), with a significantly lower quantity of UM TIL expanded overall. These studies suggest that UM and CM are immunologically distinct, and provide potential explanation for the impaired success of immunotherapy in UM.