학술논문
Immune boosting by B.1.1.529 ( Omicron) depends on previous SARS-CoV-2 exposure.
Document Type
Academic Journal
Author
Reynolds CJ; Department of Infectious Disease, Imperial College London, London, UK.; Pade C; Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; Gibbons JM; Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; Otter AD; UK Health Security Agency, Porton Down, UK.; Lin KM; Department of Infectious Disease, Imperial College London, London, UK.; Muñoz Sandoval D; Department of Infectious Disease, Imperial College London, London, UK.; Pieper FP; Department of Infectious Disease, Imperial College London, London, UK.; Butler DK; Department of Infectious Disease, Imperial College London, London, UK.; Liu S; Department of Infectious Disease, Imperial College London, London, UK.; Joy G; St Bartholomew's Hospital, Barts Health NHS Trust, London, UK.; Forooghi N; St Bartholomew's Hospital, Barts Health NHS Trust, London, UK.; Treibel TA; St Bartholomew's Hospital, Barts Health NHS Trust, London, UK.; Institute of Cardiovascular Science, University College London, London, UK.; Manisty C; St Bartholomew's Hospital, Barts Health NHS Trust, London, UK.; Institute of Cardiovascular Science, University College London, London, UK.; Moon JC; St Bartholomew's Hospital, Barts Health NHS Trust, London, UK.; Institute of Cardiovascular Science, University College London, London, UK.; Semper A; UK Health Security Agency, Porton Down, UK.; Brooks T; UK Health Security Agency, Porton Down, UK.; McKnight Á; Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; Altmann DM; Department of Immunology and Inflammation, Imperial College London, London, UK.; Boyton RJ; Department of Infectious Disease, Imperial College London, London, UK.; Lung Division, Royal Brompton and Harefield Hospitals, Guy's and St Thomas' NHS Foundation Trust, London, UK.; Abbass H; Abiodun A; Alfarih M; Alldis Z; Altmann DM; Amin OE; Andiapen M; Artico J; Augusto JB; Baca GL; Bailey SNL; Bhuva AN; Boulter A; Bowles R; Boyton RJ; Bracken OV; O'Brien B; Brooks T; Bullock N; Butler DK; Captur G; Carr O; Champion N; Chan C; Chandran A; Coleman T; Couto de Sousa J; Couto-Parada X; Cross E; Cutino-Moguel T; D'Arcangelo S; Davies RH; Douglas B; Di Genova C; Dieobi-Anene K; Diniz MO; Ellis A; Feehan K; Finlay M; Fontana M; Forooghi N; Francis S; Gibbons JM; Gillespie D; Gilroy D; Hamblin M; Harker G; Hemingway G; Hewson J; Heywood W; Hickling LM; Hicks B; Hingorani AD; Howes L; Itua I; Jardim V; Lee WJ; Jensen M; Jones J; Jones M; Joy G; Kapil V; Kelly C; Kurdi H; Lambourne J; Lin KM; Liu S; Lloyd A; Louth S; Maini MK; Mandadapu V; Manisty C; McKnight Á; Menacho K; Mfuko C; Mills K; Millward S; Mitchelmore O; Moon C; Moon J; Muñoz Sandoval D; Murray SM; Noursadeghi M; Otter A; Pade C; Palma S; Parker R; Patel K; Pawarova M; Petersen SE; Piniera B; Pieper FP; Rannigan L; Rapala A; Reynolds CJ; Richards A; Robathan M; Rosenheim J; Rowe C; Royds M; Sackville West J; Sambile G; Schmidt NM; Selman H; Semper A; Seraphim A; Simion M; Smit A; Sugimoto M; Swadling L; Taylor S; Temperton N; Thomas S; Thornton GD; Treibel TA; Tucker A; Varghese A; Veerapen J; Vijayakumar M; Warner T; Welch S; White H; Wodehouse T; Wynne L; Zahedi D; Chain B; Moon JC
Source
Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE
Subject
Language
English
Abstract
The Omicron, or Pango lineage B.1.1.529, variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) carries multiple spike mutations with high transmissibility and partial neutralizing antibody (nAb) escape. Vaccinated individuals show protection against severe disease, often attributed to primed cellular immunity. We investigated T and B cell immunity against B.1.1.529 in triple BioNTech BNT162b2 messenger RNA-vaccinated health care workers (HCWs) with different SARS-CoV-2 infection histories. B and T cell immunity against previous variants of concern was enhanced in triple-vaccinated individuals, but the magnitude of T and B cell responses against B.1.1.529 spike protein was reduced. Immune imprinting by infection with the earlier B.1.1.7 (Alpha) variant resulted in less durable binding antibody against B.1.1.529. Previously infection-naïve HCWs who became infected during the B.1.1.529 wave showed enhanced immunity against earlier variants but reduced nAb potency and T cell responses against B.1.1.529 itself. Previous Wuhan Hu-1 infection abrogated T cell recognition and any enhanced cross-reactive neutralizing immunity on infection with B.1.1.529.