학술논문
Age-Specific Relation of Cardiovascular Health Metrics With Incident Cardiovascular Disease.
Document Type
Academic Journal
Author
Itoh H; Department of Cardiovascular Medicine.; Kaneko H; Department of Cardiovascular Medicine; Department of Advanced Cardiology. Electronic address: kanekohidehiro@gmail.com.; Okada A; Department of Prevention of Diabetes and Lifestyle-Related Diseases, Graduate School of Medicine.; Suzuki Y; Department of Cardiovascular Medicine; Department of Rehabilitation Science, Graduate School of Medical Sciences, Kitasato University, Kanagawa, Japan.; Fujiu K; Department of Cardiovascular Medicine; Department of Advanced Cardiology.; Matsuoka S; Department of Cardiovascular Medicine.; Michihata N; Department of Health Services Research.; Jo T; Department of Health Services Research.; Nakanishi K; Department of Cardiovascular Medicine.; Takeda N; Department of Cardiovascular Medicine.; Morita H; Department of Cardiovascular Medicine.; Node K; Department of Cardiovascular Medicine, Saga University, Saga, Japan.; Di Tullio MR; Department of Medicine, Columbia University, New York, New York.; Homma S; Department of Medicine, Columbia University, New York, New York.; Yasunaga H; The Department of Clinical Epidemiology and Health Economics, School of Public Health, The University of Tokyo, Tokyo, Japan.; Komuro I; Department of Cardiovascular Medicine.
Source
Publisher: Excerpta Medica Country of Publication: United States NLM ID: 0207277 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1913 (Electronic) Linking ISSN: 00029149 NLM ISO Abbreviation: Am J Cardiol Subsets: MEDLINE
Subject
Language
English
Abstract
We examined the age-related differences in cardiovascular health (CVH) metrics for incident cardiovascular disease (CVD). Analyses were conducted using data from the JMDC Claims Database from 2005 to 2020 (n = 2,728,427; mean age 44.9 ± 11.0 years; 56.2% men). Participants were categorized on the basis of age: 20 to 49 years (n = 1,800,161), 50 to 59 years (n = 644,703), and 60 to 75 years (n = 283,563). Ideal CVH metrics included nonsmoking, body mass index <25 kg/m 2 , physical activity at goal, not skipping breakfast, blood pressure <120/80 mm Hg, fasting plasma glucose <100 mg/dL, and total cholesterol <200 mg/dL. Over a mean follow-up of 1,194 ± 917 days, 5,988 myocardial infarction (MI), 53,409 angina pectoris, 26,530 stroke, and 52,712 heart failure (HF) events were recorded. Number of the nonideal CVH metrics was associated with incident MI, angina pectoris, stroke, and HF in all age categories. However, the association of the number of nonideal CVH metrics with incident CVD was modified by age categories and was more pronounced in participants aged 20 to 49 years. Similarly, the relative risk reduction at 1 year for each CVD event under the virtual condition that an individual with 2 nonideal CVH metrics has decreased them to zero, decreased with age. For example, relative risk reduction for MI was 0.51 in participants aged 20 to 49 years, 0.48 in those aged 50 to 59 years, and 0.40 in those aged 60 to 75 years. In conclusion, CVH metrics were more strongly associated with incident CVD including HF among younger individuals suggesting the importance of optimizing modifiable risk factors and lifestyles in young participants for the primary CVD prevention.
Competing Interests: Disclosures Research funding and scholarship funds (Drs. Kaneko and Fujiu) from Medtronic Japan Co., Ltd., Boston Scientific Japan Co., Ltd., Biotronik Japan, Simplex Quantum Co., Ltd., and Fukuda Denshi, Central Tokyo CO., LTD. The remaining authors have no conflicts of interest to declare.
(Copyright © 2022 Elsevier Inc. All rights reserved.)
Competing Interests: Disclosures Research funding and scholarship funds (Drs. Kaneko and Fujiu) from Medtronic Japan Co., Ltd., Boston Scientific Japan Co., Ltd., Biotronik Japan, Simplex Quantum Co., Ltd., and Fukuda Denshi, Central Tokyo CO., LTD. The remaining authors have no conflicts of interest to declare.
(Copyright © 2022 Elsevier Inc. All rights reserved.)