학술논문
The hallmarks of CMV-specific CD8 T-cell differentiation.
Document Type
Academic Journal
Author
van den Berg SPH; Center for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands.; Laboratory of Translational Immunology, Department of Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.; Pardieck IN; Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands.; Lanfermeijer J; Center for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands.; Laboratory of Translational Immunology, Department of Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.; Sauce D; Sorbonne Université, INSERM, Centre d'Immunologie et des Maladies Infectieuses (CIMI-Paris), Paris, France.; Klenerman P; Nuffield Department of Medicine, Peter Medawar Building for Pathogen Research, University of Oxford, Oxford, UK.; NIHR Biomedical Research Centre, John Radcliffe Hospital, Oxford, UK.; van Baarle D; Center for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands.; Laboratory of Translational Immunology, Department of Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.; Arens R; Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands. R.Arens@lumc.nl.
Source
Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0314524 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1831 (Electronic) Linking ISSN: 03008584 NLM ISO Abbreviation: Med Microbiol Immunol Subsets: MEDLINE
Subject
Language
English
Abstract
Upon cytomegalovirus (CMV) infection, large T-cell responses are elicited that remain high or even increase over time, a phenomenon named memory T-cell inflation. Besides, the maintained robust T-cell response, CMV-specific T cells seem to have a distinctive phenotype, characterized by an advanced differentiation state. Here, we will review this "special" differentiation status by discussing the cellular phenotype based on the expression of CD45 isoforms, costimulatory, inhibitory and natural killer receptors, adhesion and lymphocyte homing molecules, transcription factors, cytokines and cytotoxic molecules. In addition, we focus on whether the differentiation state of CMV-specific CD8 T cells is unique in comparison with other chronic viruses and we will discuss the possible impact of factors such as antigen exposure and aging on the advanced differentiation status of CMV-specific CD8 T cells.